INT35654

Context Info Confidence 0.65 First Reported 1986 Last Reported 2010 Negated 1 Speculated 1 Reported most in Abstract Documents 6 Total Number 11 Disease Relevance 7.97 Pain Relevance 1.44

peptidase activity (Pgc) extracellular region (Pgc) nucleolus (Pgc) nucleus (Pgc)

Anatomy Link Frequency neck 2 isthmus 1 margin 1 muscle tissues 1 stomach 1 Pgc (Rattus norvegicus)

Pain Link Frequency Relevance Heat peptic ulcer disease 7 99.28 cINOD 11 98.80 Angina 4 91.72 alcohol 2 77.56 cytokine 5 74.20 Inflammation 20 73.80 abdominal pain 2 48.88 nud 3 40.36 Somatostatin 10 5.00 adenocard 5 5.00

Disease Link Frequency Relevance Heat Ulcers 205 99.64 Disease 7 99.28 Metaplasia 185 98.32 INFLAMMATION 28 98.24 Frailty 10 98.20 Myocardial Infarction 8 97.76 Recurrence 3 97.32 Diabetes Mellitus 14 95.96 Angina 4 91.72 Natriuresis 6 90.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also examined pepsinogen C (PgC) and F (PgF) mRNA expression by RT-PCR.

Spec (examined) Gene_expression (expression) of PgC

1) Confidence 0.65 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12843612 Disease Relevance 0.08 Pain Relevance 0.12

The cGMP production and pGC activity in response to CNP in gastric muscle tissues were significantly potentiated in STZ-induced diabetic rats.

Gene_expression (production) of pGC in muscle tissues associated with diabetes mellitus

2) Confidence 0.58 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.25 Pain Relevance 0

The injection of hydrocortisone induced PgC mRNA expression in the infant rat stomach, whereas MUC5AC and PgF mRNA expression decreased.

Gene_expression (expression) of PgC mRNA in stomach

3) Confidence 0.24 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12843612 Disease Relevance 0.07 Pain Relevance 0.10

PG I2 synthesis by rat aortic ring was inhibited by mepacrine, which inhibits phospholipase A2.

Gene_expression (synthesis) of PG I2

4) Confidence 0.20 Published 1986 Journal Jpn Heart J Section Abstract Doc Link 3553641 Disease Relevance 1.00 Pain Relevance 0.34

The relation between serum levels of pepsinogen A (PGA) and pepsinogen C (PGC) and endoscopic findings in association with short-term NSAID use was investigated in two double-blind, crossover studies in healthy volunteers.

Gene_expression (levels) of PGC associated with cinod

5) Confidence 0.15 Published 1993 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 8322031 Disease Relevance 0.10 Pain Relevance 0.37

Our results suggest that pretreatment serum PG I levels in children with PUD may predict fairly accurately which will not relapse after attaining ulcer healing by a short-term ranitidine course.

Gene_expression (levels) of PG I associated with peptic ulcer disease, ulcers and recurrence

6) Confidence 0.06 Published 1988 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 3183868 Disease Relevance 0.99 Pain Relevance 0.40

In the ulcer margin, MUC6 and pepsinogen seem to be coexpressed with TFF2 at the gland base.

Gene_expression (coexpressed) of pepsinogen in margin associated with ulcers

7) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 1.21 Pain Relevance 0

MUC6 was expressed in cells at the gland base but not in those in the neck (Figure 6e), whereas pepsinogen was expressed in cells in the neck (Figure 6f).

Gene_expression (expressed) of pepsinogen in neck

8) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.97 Pain Relevance 0

Unlike mucous neck cells in the normal mucosa, TFF2 cells in the healing ulcer coexpressed MUC5AC (but little MUC6) in the neck and also coexpressed pepsinogen.

Gene_expression (coexpressed) of pepsinogen in neck associated with ulcers

9) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 1.28 Pain Relevance 0.11

Thus, there was overlap in expression of TFF2, MUC6 and pepsinogen in cells at the base (Figure 5, d-f).

Gene_expression (expression) of pepsinogen

10) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.89 Pain Relevance 0

Parietal cells and chief cells in the isthmus were adjacent to DCAMKL1 cells, but DCAMKL1 cells did not coexpress H+/K+-ATPase or pepsinogen (Figure 2e, f).

Neg (not) Gene_expression (coexpress) of pepsinogen in isthmus

11) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.12 Pain Relevance 0

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