INT35683

Context Info Confidence 0.46 First Reported 1988 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 24 Total Number 28 Disease Relevance 16.94 Pain Relevance 3.60

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency granulocytes 5 F4/80 5 neutrophils 4 kidney 2 lungs 2 Gsr (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 597 99.28 Arthritis 146 98.40 withdrawal 8 97.08 ischemia 48 96.76 carrageenan induced 1 96.44 rheumatoid arthritis 94 96.16 Sciatic nerve 39 92.00 Analgesic 5 85.84 Inflammatory response 60 80.72 Paracetamol 3 78.04

Disease Link Frequency Relevance Heat Targeted Disruption 212 100.00 Cancer 407 99.96 INFLAMMATION 625 99.28 Injury 42 98.88 Arthritis 153 98.40 Shock 30 98.36 Mycobacterial Infection 581 97.24 Necrosis 46 97.00 Diabetes Mellitus 106 96.88 Cv Unclassified Under Development 40 96.76

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While catalase was significantly greater in adults, glutathione peroxidase, glutathione reductase and superoxide dismutase were all higher in the 2-week-old mice.

Gene_expression (higher) of glutathione reductase

1) Confidence 0.46 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 3190756 Disease Relevance 0.16 Pain Relevance 0.08

by Gr1-CD11b+ microglia and macrophages

Gene_expression (by) of Gr1 in macrophages

2) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.25 Pain Relevance 0.19

Because a subpopulation of the infiltrating GFP+ cells were identified as granulocytes (Figure 7A), we first investigated if Gr1+ granulocytes express IL-1?

Gene_expression (granulocytes) of Gr1 in granulocytes

3) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.14 Pain Relevance 0.07

The anti-granulocyte antibody GR1 restored tumor growth rate in the PPAR?

Gene_expression (The) of GR1 in granulocyte associated with cancer

4) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.22 Pain Relevance 0.08

The anti-granulocyte antibody GR1 restored tumor growth rate in the PPAR?

Gene_expression (restored) of GR1 in granulocyte associated with cancer

5) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.21 Pain Relevance 0.08

In order to investigate the anti-inflammatory mechanism of MKGS, we analyzed the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver, and the levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF-alpha), malondialdehyde (MDA) and nitric oxide (NO) in the edema paw tissue.

Spec (analyzed) Gene_expression (activities) of glutathione reductase in MKGS associated with pressure and volume under development, necrosis, inflammation and cancer

6) Confidence 0.24 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 0.84 Pain Relevance 0.46

and Tg+ sick mice were harvested and flow cytometry was used to identify various immune cells, including macrophages (F4/80), monocytes (Cd11b), T cells (CD3), and neutrophils (Gr1).

Gene_expression (neutrophils) of Gr1 in monocytes

7) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.43 Pain Relevance 0.15

Gr1 (Ly6G/Ly6C) is a marker that is expressed on both neutrophils as well as on a population of inflammatory monocytes [65], [66], [67].

Gene_expression (expressed) of Gr1 in inflammatory monocytes associated with inflammation

8) Confidence 0.20 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.97 Pain Relevance 0.20

Furthermore, in the condition of anti-Gr-1 depletion, B7-H4VC treatment did not have a significant effect in exacerbation of CIA (Figure 4B).

Gene_expression (depletion) of Gr-1 associated with arthritis

9) Confidence 0.19 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.10 Pain Relevance 0.46

Within the GR-1hi population, CD11b expression was not modified by the IR injury in either WT or MC3R-null animals; however, granulocytes from IR MC3R-null animals displayed an increased CD11b expression when compared with WT animals.

Gene_expression (expression) of GR-1hi in granulocytes associated with injury

10) Confidence 0.18 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.27 Pain Relevance 0

Together, these data suggest that the early recruitment of Gr1+ neutrophils may play a role in regulating the adaptive T cell immunity during M.tuberculosis infection.

Gene_expression (neutrophils) of Gr1 in neutrophils associated with mycobacterial infection and infection

11) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.01 Pain Relevance 0.03

To our knowledge, this is the first study to experimentally show that the accumulation of Gr1+ neutrophils in the lungs takes place prior to accumulation of adaptive T cells.

Gene_expression (neutrophils) of Gr1 in lungs

12) Confidence 0.15 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.37 Pain Relevance 0

Interestingly, depletion of Gr1+ neutrophils between D10–15 did not impact accumulation of total CD4+ T cells in the lungs (Figure 7a), but resulted in decreased accumulation of activated CD4+ cells (Figure 7b) and decreased percentage and number of IFN?

Gene_expression (neutrophils) of Gr1 in lungs

13) Confidence 0.15 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.54 Pain Relevance 0

In the present study, we demonstrated that CD11b+/Gr-1-/lo OCPs from joints of TNF-Tg mice produce high levels of the lymphatic growth factor, VEGF-C, and that joints from mice in two models of RA have increased numbers of lymphatic vessels and enlargement of draining popliteal lymph nodes.

Gene_expression (produce) of Gr-1 in lymphatic vessels associated with targeted disruption and rheumatoid arthritis

14) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 1.30 Pain Relevance 0.54

During the detoxification process GSH (reduced form) becomes oxidized glutathione (GSSG) which is then recycled to GSH by the enzyme glutathione reductase present in cells.

Gene_expression (present) of glutathione reductase

15) Confidence 0.15 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.67 Pain Relevance 0

by Gr1-CD11b+ microglia and macrophages

Gene_expression (by) of Gr1 in microglia

16) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.25 Pain Relevance 0.19

-glutamyl transpeptidase, GPX glutathione peroxidase, GR glutathione reductase, GST glutathione-S-transferase, GSSG glutathione disulfideFigure 3Heat shock protein 70 protein levels in kidney tissues from Ames dwarf and wild-type mice at 3, 12, and 24 months of age.

Gene_expression (glutathione-S-transferase) of glutathione reductase in kidney associated with shock

17) Confidence 0.14 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.51 Pain Relevance 0

-glutamyl transpeptidase, GPX glutathione peroxidase, GR glutathione reductase, GST glutathione-S-transferase, GSSG glutathione disulfideFigure 3Heat shock protein 70 protein levels in kidney tissues from Ames dwarf and wild-type mice at 3, 12, and 24 months of age.

Gene_expression (glutathione peroxidase) of glutathione reductase in kidney associated with shock

18) Confidence 0.14 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.51 Pain Relevance 0

Neutrophils were identified based on forward/side-scatter properties and F4/80 and Gr-1 expression.

Gene_expression (expression) of Gr-1 in F4/80

19) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.11 Pain Relevance 0.15

Relative expression of target mRNAs (Adiponectin Mm00456425_m1, Arg1 Mm00475988_m1, Bcl2 Mm00477631_m1, Bax Mm00432050_m1, Ccl2 Mm00441242_m1, Ccl3 Mm00441258, Ccl5 Mm01302428_m1, Cxcl5 Mm00436451_g1, CD11c Mm00498698_m1, CD3 Mm00442746_m1, CD34 Mm00519283_m1, CD4 Mm00442754_m1, CD8 Mm01182108_m1, F4/80 Mm00802530_m1, G6pase Mm839363_m1, Gr-1 Mm00459644_m1, Il1?

Gene_expression (expression) of Gr-1 in F4/80

20) Confidence 0.11 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.27 Pain Relevance 0

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