INT35689

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.30
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cleavage 3
plasma 2
parietal 1
microglial cells 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
cytokine 7 100.00 Very High Very High Very High
Neuropathic pain 7 99.52 Very High Very High Very High
Arthritis 1 98.16 Very High Very High Very High
Pain 6 97.92 Very High Very High Very High
Inflammation 67 97.76 Very High Very High Very High
substance P 2 95.52 Very High Very High Very High
Central nervous system 1 90.56 High High
Opioid 1 88.96 High High
Morphine 4 83.36 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Neuropathic Pain 8 99.52 Very High Very High Very High
Disease 174 99.26 Very High Very High Very High
Arthritis 1 98.16 Very High Very High Very High
Arthralgia 3 97.94 Very High Very High Very High
Pain 6 97.92 Very High Very High Very High
Schizophrenia 172 97.86 Very High Very High Very High
INFLAMMATION 79 97.76 Very High Very High Very High
Nociception 1 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study seven patients, operated 4 months--4.5 years previously and exhibiting postoperative arthralgias, arthritis, and/or skin rashes, were investigated with regard to their PMN adherence and bactericidal capacity and plasma levels of complement factors 3 and 4 (C3 and C4).
Localization (capacity) of C3 in plasma associated with arthralgia and arthritis
1) Confidence 0.75 Published 1980 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7433890 Disease Relevance 0.28 Pain Relevance 0.05
Among the various biologically active peptides tested, the purified enzyme releases efficiently the N-terminal dipeptide moiety from enkephalins, Trp-Met-Asp-Phe-NH2 (CCK4), and Gly-Trp-Met-Asp-Phe-NH2 (CCK5).
Localization (releases) of Asp associated with enkephalin
2) Confidence 0.73 Published 1986 Journal Biochemistry Section Abstract Doc Link 3814577 Disease Relevance 0 Pain Relevance 0.37
Among the various biologically active peptides tested, the purified enzyme releases efficiently the N-terminal dipeptide moiety from enkephalins, Trp-Met-Asp-Phe-NH2 (CCK4), and Gly-Trp-Met-Asp-Phe-NH2 (CCK5).
Localization (releases) of Asp associated with enkephalin
3) Confidence 0.68 Published 1986 Journal Biochemistry Section Abstract Doc Link 3814577 Disease Relevance 0 Pain Relevance 0.37
Purified human complement protein C3 (Quidel), a chicken polyclonal antiserum against human complement C3 (Genway), rabbit polyclonal antiserum against human C3 biotinylated (Abcam), and HRP-conjugated streptavidin (Rockland) were used to measure C3.
Localization (measure) of C3
4) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.05 Pain Relevance 0
Purified human complement protein C3 (Quidel), a chicken polyclonal antiserum against human complement C3 (Genway), rabbit polyclonal antiserum against human C3 biotinylated (Abcam), and HRP-conjugated streptavidin (Rockland) were used to measure C3.
Localization (measure) of C3
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.05 Pain Relevance 0
The synchronization landscape in SZ is characterized by hyper-synchronization significant for 3 centro-parietal sensors (corresponding to the C3, CP3, and CP5 locations of the extended 10–20 system) over the left hemisphere and for a large cluster of 10 sensors over the right hemisphere.
Localization (locations) of C3 in parietal associated with schizophrenia
6) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020441 Disease Relevance 0.36 Pain Relevance 0
Indeed, for the vast majority of locations no significant differences (patterns) emerged when comparing the patients' S-maps derived from the first and second EEG sessions (Fig. 4C), although S-estimator values for two sensors (35 and 38 located near C3 and F7, respectively) varied significantly (P?
Localization (located) of C3
7) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020441 Disease Relevance 0.36 Pain Relevance 0
The antibody used to detect iC3b in this study is iC3b-specific and does not recognize the native complement protein C3 from which iC3b is generated. iC3b staining of melanized neurons is therefore evidence for early complement activation, i.e., cleavage of C3, on these cells. iC3b and its active form, C3b, are opsonins, promoting phagocytosis of foreign antigens and cell debris.
Localization (cleavage) of C3 in cleavage
8) Confidence 0.28 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 0.40 Pain Relevance 0.13
Consequently, a remarkable increase in disease duration with disease severity was observed in our study, ranging from 20.1 years for C2, via 23.4 years and 25.3 years for C3 and C4, respectively, to 29.8 years for C5&C6.
Localization (ranging) of C3 associated with disease
9) Confidence 0.21 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 1.30 Pain Relevance 0
During complement activation by the alternative pathway, plasma protein C3 is cleaved into the large opsonizing factor C3b and the small pro-inflammatory peptide C3a and precursor B is cleaved into a large Bb fragment and a small Ba peptide.
Localization (cleaved) of C3 in plasma associated with inflammation
10) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.24 Pain Relevance 0.05
Cleavage of C3
Localization (Cleavage) of C3 in Cleavage
11) Confidence 0.16 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.25 Pain Relevance 0
Both C3 convertases (C4b2a and C3bBb) cleave C3 into C3a and C3b.
Localization (convertases) of C3
12) Confidence 0.16 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.13 Pain Relevance 0
IxACs inhibit the cleavage of human C3 and factor B
Localization (cleavage) of C3 in cleavage
13) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.24 Pain Relevance 0.04
Both C1s and MASP-2 cleave complement proteins C4 and C2 to generate the CP/LP C3 convertase: C4b2a.
Localization (convertase) of C3
14) Confidence 0.14 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.07 Pain Relevance 0
Both C3 convertases (C4b2a and C3bBb) cleave C3 into C3a and C3b.
Localization (convertases) of C3
15) Confidence 0.14 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.13 Pain Relevance 0
In both saline- and ibuprofen-treated animals, there was extensive localization of C4, C3, and C5 in all infarct sites; in contrast, there was only C4 localization in the CVF-treated baboons.
Localization (localization) of C3
16) Confidence 0.11 Published 1988 Journal Circulation Section Abstract Doc Link 3191598 Disease Relevance 0.65 Pain Relevance 0.06
There is increasing evidence that uncontrolled activation of microglial cells under neuropathic pain conditions induces the release of proinflammatory cytokines (interleukin - IL-1beta, IL-6, tumor necrosis factor - TNF-alpha), complement components (C1q, C3, C4, C5, C5a) and other substances that facilitate pain transmission.
Localization (release) of C3 in microglial cells associated with pain, necrosis, cancer, neuropathic pain and cytokine
17) Confidence 0.09 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 18622054 Disease Relevance 0.79 Pain Relevance 0.91

General Comments

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