INT35699

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
plasma membrane (Umod)
Anatomy Link Frequency
renal tubules 1
tubules 1
Umod (Mus musculus)
Pain Link Frequency Relevance Heat
interstitial cystitis 7 99.92 Very High Very High Very High
Inflammation 2 82.88 Quite High
addiction 1 46.24 Quite Low
methotrexate 22 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 7 99.92 Very High Very High Very High
Proteinuria 3 96.56 Very High Very High Very High
Acute Renal Failure 60 95.44 Very High Very High Very High
Renal Disease 13 94.60 High High
Pressure Volume 2 Under Development 1 92.24 High High
Sepsis 4 91.12 High High
Renal Failure 9 90.12 High High
Kidney Stones 1 88.96 High High
INFLAMMATION 2 82.88 Quite High
Multiple Myeloma 1 82.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interstitial cystitis is associated with intraurothelial Tamm-Horsfall protein.
Tamm-Horsfall protein Binding (associated) of associated with interstitial cystitis
1) Confidence 0.41 Published 1988 Journal J. Urol. Section Title Doc Link 3193502 Disease Relevance 0.72 Pain Relevance 0.46
In any case, excreted uromodulin may be reflecting GL-3 buildup in the distal tubules, and these changes can be normalized most effectively in the mouse model by a combined ERT plus SRT approach.


uromodulin Binding (be) of in tubules
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Numerous casts are present in the renal tubules, which are formed when light chains bind to a specific peptide domain on the Tamm-Horsfall protein [17]; variations in CDR3 in both the ?
Tamm-Horsfall protein Binding (bind) of in renal tubules
3) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1550893 Disease Relevance 1.58 Pain Relevance 0

General Comments

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