INT35711

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 110
Total Number 110
Disease Relevance 50.45
Pain Relevance 22.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 8
liver 8
lens 4
blood 3
muscle 3
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 91 100.00 Very High Very High Very High
ischemia 556 99.82 Very High Very High Very High
Morphine 40 99.78 Very High Very High Very High
fluoxetine 19 99.68 Very High Very High Very High
Paracetamol 125 99.62 Very High Very High Very High
cerebral cortex 13 99.56 Very High Very High Very High
Pain 73 99.44 Very High Very High Very High
narcan 24 99.38 Very High Very High Very High
withdrawal 27 99.32 Very High Very High Very High
qutenza 11 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 645 100.00 Very High Very High Very High
Urological Neuroanatomy 16 100.00 Very High Very High Very High
Diabetes Mellitus 384 99.84 Very High Very High Very High
Heart Rate Under Development 158 99.84 Very High Very High Very High
Cv Unclassified Under Development 458 99.82 Very High Very High Very High
Disorder Of Lipid Metabolism 305 99.80 Very High Very High Very High
Hypoxia 34 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 31 99.64 Very High Very High Very High
Shock 25 99.20 Very High Very High Very High
Neuropathic Pain 69 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine treatment increased MDA levels.
Positive_regulation (increased) of MDA associated with morphine
1) Confidence 0.60 Published 2008 Journal Fundam Clin Pharmacol Section Abstract Doc Link 18705754 Disease Relevance 0 Pain Relevance 1.36
The administration of morphine or its removal by naloxone alters plasma glucose levels, increases MDA values, and also affects signs such as pain threshold values, fecal excretion and jumping behaviour.
Positive_regulation (increases) of MDA in plasma associated with pain threshold, narcan and morphine
2) Confidence 0.60 Published 2009 Journal Arzneimittelforschung Section Abstract Doc Link 19338137 Disease Relevance 0.15 Pain Relevance 1.49
The amount of MDA was significantly increased in the hypoxic ischemic (HI) hemisphere ipsilateral to the carotid ligation compared with contralateral hypoxic hemisphere.
Positive_regulation (increased) of MDA associated with hypoxia
3) Confidence 0.43 Published 1997 Journal Brain Res. Section Abstract Doc Link 9409714 Disease Relevance 0.66 Pain Relevance 0.20
Abrupt naloxone-induced morphine withdrawal caused a further and significant increase in MDA, and the appearance of withdrawal signs such as abnormal fecal excretion, shortened latency times and jumping.
Positive_regulation (increase) of MDA associated with narcan, withdrawal and morphine
4) Confidence 0.40 Published 2008 Journal Fundam Clin Pharmacol Section Abstract Doc Link 18705754 Disease Relevance 0 Pain Relevance 1.37
These results show that the ASA-induced gastric mucosal damage is accompanied by the development of oxidative stress, evidenced by the accumulation of MDA, and concomitant initial activation of cell antioxidant defences.
Positive_regulation (accumulation) of MDA associated with stress and aspirin
5) Confidence 0.40 Published 2002 Journal Pharmacol. Res. Section Abstract Doc Link 12220953 Disease Relevance 0.16 Pain Relevance 0.72
Paracetamolum (PC) after i.p. administration to rats at the therapeutic (100.0 mg/kg) and subtoxic (500.0 mg/kg) doses was shown to induce significant and dose-dependent elevation of the level of malone dialdehyde (MDA) as well as the increase in a certain extent of chemiluminescence (CL) being injected at the higher dose.
Positive_regulation (elevation) of MDA
6) Confidence 0.40 Published 1996 Journal Eksp Klin Farmakol Section Abstract Doc Link 8704633 Disease Relevance 0 Pain Relevance 0.20
The S. leriifolia extracts reversed the increase of MDA levels to a considerable extent, thereby confirming its antioxidant role in I/R.
Positive_regulation (increase) of MDA
7) Confidence 0.35 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.23 Pain Relevance 0.05
MDA levels increased significantly following muscle ischemia reperfusion.
Positive_regulation (increased) of MDA in muscle associated with ischemia
8) Confidence 0.31 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.35 Pain Relevance 0.07
There was an increase in the MDA levels following ischemia reperfusion as compared with sham-operated animals (20.18 ± 3.65 vs 88.53 ± 3.65 nM/g tissue, p < 0.01) (Figure 2 and 3).
Positive_regulation (increase) of MDA associated with ischemia
9) Confidence 0.31 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.35 Pain Relevance 0.18
The MDA level in the left HI hemisphere was also significantly elevated at 0, 15, 30 and 60 min, but not at 180 min into the reoxygenation period.
Positive_regulation (elevated) of MDA
10) Confidence 0.29 Published 1997 Journal Brain Res. Section Abstract Doc Link 9409714 Disease Relevance 0.63 Pain Relevance 0.20
The results demonstrate that both 12 and 72 hr following IR, tissue levels of MDA were elevated (P < 0.001), while GSH levels were reduced (P < 0.01) in both tissues.
Positive_regulation (elevated) of MDA
11) Confidence 0.28 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15485549 Disease Relevance 0.07 Pain Relevance 0.11
Pretreatment of rats with fluoxetine resulted in an increase in MDMA (1.4-fold) and MDA (1.5-fold) exposure in both brain and plasma.
Positive_regulation (increase) of MDA in brain associated with fluoxetine
12) Confidence 0.24 Published 2008 Journal J Pharm Sci Section Abstract Doc Link 17724664 Disease Relevance 0.13 Pain Relevance 0.59
Present study showed that S. lerrifolia extracts suppressed the increase of MDA levels in the rat skeletal muscle and therefore inhibited lipid peroxidation following ischemia-reperfusion injury.
Positive_regulation (increase) of MDA in skeletal muscle associated with reperfusion injury and ischemia
13) Confidence 0.24 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.82 Pain Relevance 0.36
Current findings showed that MDA levels were increased and SOD and CAT activities were decreased in cadmium exposed group compared to control group.
Positive_regulation (increased) of MDA
14) Confidence 0.17 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16424996 Disease Relevance 0.15 Pain Relevance 0.07
IAA and DEM produced a comparable, modest accumulation of MDA, yet IAA was much more cytotoxic.
Positive_regulation (accumulation) of MDA
15) Confidence 0.15 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0.09 Pain Relevance 0.37
Antioxidant enzyme (superoxide dismutase and catalase) levels were reduced and malondialdehyde (MDA) levels were significantly increased in diabetic rats as compared to the age-matched control rats, this indicates the involvement of oxidative stress in diabetic neuropathy.
Positive_regulation (increased) of MDA associated with stress, diabetes mellitus and diabetic neuropathy
16) Confidence 0.15 Published 2006 Journal Life Sci. Section Abstract Doc Link 16581090 Disease Relevance 1.42 Pain Relevance 0.49
In the present study TMZ has inhibited the increase in MDA values of the retinal tissue which has undergone I/R.
Positive_regulation (increase) of MDA
17) Confidence 0.14 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0.68 Pain Relevance 0.07
The mean free MDA level increased in the placebo group (P = 0.006) but not in the drug group (P > 0.05).
Neg (not) Positive_regulation (increased) of MDA
18) Confidence 0.13 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2819765 Disease Relevance 0.52 Pain Relevance 0.11
Increments of MPO and MDA contents, as well as a decrease in GSH levels were detected in the gastric mucosa of indomethacin- or piroxicam-treated animals.
Positive_regulation (Increments) of MDA
19) Confidence 0.12 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15996031 Disease Relevance 0.13 Pain Relevance 0
Although plasma MDA levels were higher in group 2, MDA levels in liver tissues were comparable.
Positive_regulation (higher) of MDA in liver
20) Confidence 0.12 Published 2003 Journal Biol Trace Elem Res Section Abstract Doc Link 14716100 Disease Relevance 0.34 Pain Relevance 0.09

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