INT35712

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Context Info
Confidence 0.23
First Reported 1988
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 5.30
Pain Relevance 6.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 3
liver 1
midbrain 1
PGE2 1
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 16 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
aspirin 12 99.90 Very High Very High Very High
ischemia 66 99.66 Very High Very High Very High
narcan 24 99.58 Very High Very High Very High
midbrain 8 99.52 Very High Very High Very High
Morphine 40 99.30 Very High Very High Very High
Pain threshold 2 98.68 Very High Very High Very High
Paracetamol 7 98.62 Very High Very High Very High
diabetic neuropathy 6 94.84 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 3 100.00 Very High Very High Very High
Urological Neuroanatomy 3 100.00 Very High Very High Very High
Cv Unclassified Under Development 49 99.66 Very High Very High Very High
Stress 121 99.60 Very High Very High Very High
Hypoxia 9 99.42 Very High Very High Very High
Diabetes Mellitus 11 99.18 Very High Very High Very High
Pain 4 98.68 Very High Very High Very High
Hypothermia 6 98.64 Very High Very High Very High
Body Weight 29 97.20 Very High Very High Very High
Injury 47 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glycemia levels, MDA values and behavioural signs seem to be interconnected in the reported experiments.
Regulation (values) of MDA
1) Confidence 0.23 Published 2009 Journal Arzneimittelforschung Section Abstract Doc Link 19338137 Disease Relevance 0.15 Pain Relevance 1.31
As paracetamol and propacetamol tend to decrease gastric lesions caused by ASA and alter gastric mucosal MDA, glutathione and UA values in a favorable manner, it could be suggested that their effects on the gastric mucosa could be related to interference with oxidative stress development.
Regulation (alter) of MDA associated with stress, aspirin and paracetamol
2) Confidence 0.23 Published 2002 Journal Pharmacol. Res. Section Abstract Doc Link 12220953 Disease Relevance 0.19 Pain Relevance 0.69
The administration of LA lowered MDA levels in the rats treated with morphine or morphine plus naloxone, and also decreased MDA values and abstinence signs in the animals treated with morphine plus naloxone.
Regulation (values) of MDA associated with narcan and morphine
3) Confidence 0.23 Published 2008 Journal Fundam Clin Pharmacol Section Abstract Doc Link 18705754 Disease Relevance 0 Pain Relevance 1.34
The administration of morphine or its removal by naloxone alters plasma glucose levels, increases MDA values, and also affects signs such as pain threshold values, fecal excretion and jumping behaviour.
Regulation (values) of MDA in plasma associated with pain threshold, narcan and morphine
4) Confidence 0.23 Published 2009 Journal Arzneimittelforschung Section Abstract Doc Link 19338137 Disease Relevance 0.16 Pain Relevance 1.50
The 2-week treatment with U83836E (3 and 9 mg/kg, i.p.) started 6 weeks after diabetes induction significantly ameliorated the alterations in MNCV, NBF, hyperalgesia, MDA levels and antioxidant enzymes in diabetic rats.
Regulation (alterations) of MDA associated with hyperalgesia and diabetes mellitus
5) Confidence 0.15 Published 2006 Journal Life Sci. Section Abstract Doc Link 16581090 Disease Relevance 1.44 Pain Relevance 0.49
Lansoprazole at 90 micromol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression.
Regulation (effects) of MDA
6) Confidence 0.11 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15996031 Disease Relevance 0 Pain Relevance 0
Pantoprazole 60 micromol/kg also reversed the effects of NSAIDs on MPO, MDA, and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced COX-2 expression.
Regulation (effects) of MDA in PGE2 associated with cinod and urological neuroanatomy
7) Confidence 0.09 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16080005 Disease Relevance 0.40 Pain Relevance 0.54
We presented the free MDA values and the tissue thicknesses of each group as the mean ± standard deviation (SD) and the statistical analysis was made using a Mann–Whitney U test.
Regulation (values) of MDA
8) Confidence 0.08 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0 Pain Relevance 0
The mean free MDA level of the control, the placebo and the drug groups was 5.13 ± 0.92, 9.45 ± 1.82 and 5.25 ± 1.02 nmol MDA/g wet tissue, respectively.
Regulation (control) of MDA
9) Confidence 0.08 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0 Pain Relevance 0
Stress exposure caused no change in SOD and MDA, but abruptly reduced the fall of SOD in adapted animals.
Neg (no) Regulation (change) of MDA associated with stress
10) Confidence 0.06 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3196845 Disease Relevance 0.43 Pain Relevance 0.09
Adaptation to moderate intermittent hypoxia in altitude chamber did not affect MDA and increased hepatic SOD by 65%.
Neg (not) Regulation (affect) of MDA associated with hypoxia
11) Confidence 0.06 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3196845 Disease Relevance 0.44 Pain Relevance 0.09
In the present investigation, ischemia and I/R did not change the plasma and renal levels of MDA and NOx, and according to the pathophysiology of I/R, these results can be due to reperfusion insufficient time.
Neg (not) Regulation (change) of MDA in plasma associated with ischemia
12) Confidence 0.04 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2913934 Disease Relevance 0.32 Pain Relevance 0.20
Table 3 demonstrates the effect of vitamin B6 deficiency on MDA levels.
Regulation (effect) of MDA
13) Confidence 0.04 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.11 Pain Relevance 0
Table 3 shows the effect of moderate physical training on liver MDA levels.
Regulation (effect) of MDA in liver
14) Confidence 0.04 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2882571 Disease Relevance 0.30 Pain Relevance 0
On recovery of Trec 37°C from C-H-R exposure-induced hypothermia, the CAT values remained low but SOD showed an increase, which was reflected in normalized plasma MDA levels.
Regulation (reflected) of MDA in plasma associated with hypothermia
15) Confidence 0.03 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062147 Disease Relevance 0.90 Pain Relevance 0
The effects of Rofecoxib on histological damage, intestinal myeloperoxidase (MPO) activity, and malondialdehyde (MDA) levels were also measured.
Regulation (effects) of MDA
16) Confidence 0.03 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16780881 Disease Relevance 0.08 Pain Relevance 0
The effect of coffee intake and exercise on MDA levels is shown in Table 6 and Fig. 3.
Regulation (effect) of MDA
17) Confidence 0.02 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0 Pain Relevance 0
Thus, it is suggested that moderate physical training, repetition of short-term generation of increased vascular oxidative stress, induced an increase of antioxidative enzyme activity and the antioxidant status but did not seem to significantly contribute to the changes of live MDA levels.
Regulation (changes) of MDA associated with stress
18) Confidence 0.02 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2882571 Disease Relevance 0.39 Pain Relevance 0
The vehicle infused midbrain did not experience any change in the MDA level and GSH or SOD activity as compared to the contralateral side.
Regulation (change) of MDA in midbrain associated with midbrain
19) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0 Pain Relevance 0.33

General Comments

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