INT35716

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 45
Total Number 47
Disease Relevance 18.00
Pain Relevance 23.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
A15 3
platelet 2
T-helper cell 2
T cells 2
brain 1
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 122 100.00 Very High Very High Very High
c fibre 48 100.00 Very High Very High Very High
cocaine 24 100.00 Very High Very High Very High
Kappa opioid receptor 7 100.00 Very High Very High Very High
Nucleus accumbens 6 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
imagery 69 99.80 Very High Very High Very High
Dynorphin 16 99.74 Very High Very High Very High
Central nervous system 54 99.68 Very High Very High Very High
Cholecystokinin 1 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 8 100.00 Very High Very High Very High
Psychosis 6 99.84 Very High Very High Very High
Disease 139 99.68 Very High Very High Very High
Delirium 20 99.66 Very High Very High Very High
Breast Cancer 82 99.48 Very High Very High Very High
Infection 13 99.38 Very High Very High Very High
INFLAMMATION 158 99.28 Very High Very High Very High
Muscle Hypertonia 2 99.16 Very High Very High Very High
Apoptosis 55 98.98 Very High Very High Very High
Overdose 14 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of alpha receptors produces a contraction whilst activation of the beta adrenoceptors causes relaxation.
Positive_regulation (Activation) of receptors
1) Confidence 0.60 Published 1988 Journal Exp. Eye Res. Section Abstract Doc Link 3197766 Disease Relevance 0 Pain Relevance 0.18
Activation of meningeal 5-HT2B receptors: an early step in the generation of migraine headache?
Positive_regulation (Activation) of receptors associated with migraine and headache
2) Confidence 0.38 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8743744 Disease Relevance 0.47 Pain Relevance 0.81
Recently, it has been shown that elevated SMRT levels result in suppression of target genes for the vitamin D receptor (VDR) in prostate cancer cells and in apparent hormonal insensitivity (Khanim et al. 2004).
Positive_regulation (elevated) of SMRT associated with reprotox - general 1
3) Confidence 0.37 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.15 Pain Relevance 0.03
However, a potential involvement of sigma receptors in psychotic disorders was first suggested soon after their discovery.
Positive_regulation (involvement) of receptors associated with psychosis
4) Confidence 0.36 Published 2004 Journal Pharmacopsychiatry Section Abstract Doc Link 15547784 Disease Relevance 0.10 Pain Relevance 0.26
Our data suggest that a protective mechanism exerted by dynorphin release and activation of kappa receptors may be lost in hippocampi with recurrent mossy fiber sprouting.
Positive_regulation (activation) of receptors in mossy fiber associated with dynorphin
5) Confidence 0.33 Published 1999 Journal Neuroscience Section Abstract Doc Link 10579209 Disease Relevance 0.25 Pain Relevance 0.57
These studies suggest that a) placental trophoblast has the capacity for the synthesis and release of PGE2 into fetal and maternal circulations; b) PGE2 exhibits differential effects in the placental and uterine blood vessels, vaso-constriction in placental vessels and vasodilation in uterine blood vessels, and (c) PGE2 exhibits dual effects on blood vessels possibly by activating two different subtypes of PG-receptors.
Spec (possibly) Positive_regulation (activating) of PG-receptors in PGE2 associated with increased venous pressure under development
6) Confidence 0.31 Published 1997 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 9193797 Disease Relevance 0.10 Pain Relevance 0
The number of kappa opioid receptors in the nucleus accumbens and other corticolimbic areas from cocaine fatalities was increased twofold as compared to control values.
Positive_regulation (increased) of receptors in nucleus accumbens associated with nucleus accumbens, kappa opioid receptor and cocaine
7) Confidence 0.09 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415668 Disease Relevance 0.60 Pain Relevance 1.28
Cocaine-overdose victims exhibiting preterminal excited delirium had a selective upregulation of kappa receptors measured also in the amygdala.
Positive_regulation (upregulation) of receptors in amygdala associated with delirium, amygdala, overdose and cocaine
8) Confidence 0.09 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415668 Disease Relevance 0.58 Pain Relevance 1.23
This suggests that PCP may produce a significant fraction of its c-fos induction via sigma2 receptors.
Positive_regulation (induction) of receptors
9) Confidence 0.06 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.05 Pain Relevance 0.44
Prolonged presence of alcohol-GABA agonist in the brain appears to produce a relative 'deficiency' of GABA in the CNS that is due to the upregulation of receptors, and possibly due to the involvement of other negative feedback mechanisms.
Positive_regulation (upregulation) of receptors in brain associated with gaba, agonist, central nervous system and alcohol
10) Confidence 0.04 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.37 Pain Relevance 1.26
CTAP alone at doses of 0.1 microM and higher up-regulated mu receptors.
Positive_regulation (up-regulated) of receptors
11) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.15 Pain Relevance 1.01
Although the neuropharmacologic mechanism of action of propofol has not yet been elucidated completely, there is evidence suggesting that propofol may potentiate GABA-evoked responses and may activate the GABA-A receptors [68].
Positive_regulation (activate) of receptors associated with gaba
12) Confidence 0.03 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.39 Pain Relevance 0.36
The nonselective antagonist naloxone provided a more robust upregulation (> 40%) of both mu and delta receptors than either selective antagonist alone or in combination.
Positive_regulation (upregulation) of receptors associated with antagonist and narcan
13) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.13 Pain Relevance 1.01
The mu-to-delta ratio (1.4 to 1) was not altered by differentiation of the cells with retinoic acid, which up-regulated both mu and delta receptors.
Positive_regulation (up-regulated) of receptors
14) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.07 Pain Relevance 0.79
Selective stimulation of ET receptors has been implicated as a cause of inflammatory, neuropathic and tumoural pain.
Positive_regulation (stimulation) of receptors associated with pain, inflammation and neuropathic pain
15) Confidence 0.02 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18194815 Disease Relevance 1.38 Pain Relevance 1.32
Novel mechanisms to stimulate GI motility and transit include blockade of cholecystokinin (CCK)A receptors and stimulation of motilin receptors.
Positive_regulation (stimulation) of receptors associated with cholecystokinin
16) Confidence 0.02 Published 1999 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10202210 Disease Relevance 0.27 Pain Relevance 0.78
These data indicate that activation of delta-opioid receptors can reduce naloxone-induced LH release, suggesting a possible role of delta receptors in opioidergic modulation of LH secretion in women.
Positive_regulation (activation) of receptors associated with narcan and delta opioid receptors
17) Confidence 0.02 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.57
Group A16 contains the opsins, receptors that are activated by isoprenoid ligands, and no orphan receptors.


Positive_regulation (activated) of receptors
18) Confidence 0.02 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.13
Protease-activated receptors become activated by a part of the former amino terminus cleaved by the protease.
Positive_regulation (activated) of receptors
19) Confidence 0.02 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.03
In group A12, the platelet-activated receptor, a lipid receptor and receptors activated by nucleotides mingle, but are found on different side branches.
Positive_regulation (activated) of receptors in platelet
20) Confidence 0.02 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0

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