INT35719

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 15.75
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Anatomy Link Frequency
endothelial cells 1
brain 1
M cell 1
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 2 94.96 High High
anesthesia 33 94.32 High High
antinociception 1 34.88 Quite Low
Central nervous system 1 25.00 Low Low
fibrosis 7 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 830 99.68 Very High Very High Very High
Apoptosis 792 99.30 Very High Very High Very High
Breast Cancer 59 98.30 Very High Very High Very High
Telangiectasia 57 96.36 Very High Very High Very High
Solid Tumor 240 94.76 High High
Dna Damage 18 94.48 High High
Squamous Cell Carcinoma 120 94.16 High High
Female Infertility 2 92.92 High High
Ataxia 142 90.88 High High
Lymphatic System Cancer 2 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that expression of ATM was dramatically reduced after cells were transfected with ATM AS-ODNs compared with that Sen-ODNs and Mis-ODNs treated groups, which indicated that the inhibition was specific for the ATM antisense sequence.
Gene_expression (expression) of ATM
1) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.17 Pain Relevance 0
From flow cytometry, we found that the cells did not accumulate in the G2/M phase following irradiation in cells transfected with ATM AS-ODNs, which mean the reduced ATM expression resulted in the defective G2/M checkpoint control.
Gene_expression (expression) of ATM
2) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.51 Pain Relevance 0
The ATM protein expression of the tumor in the different groups were ananlysed by western blot using the procedures described as above.
Gene_expression (expression) of ATM associated with cancer
3) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 1.25 Pain Relevance 0.06
Then we investigated whether the reduction of ATM expression resulted in radiosensitization in SCCVII cells.
Gene_expression (expression) of ATM
4) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.20 Pain Relevance 0
Moreover, we found that radiation-induced apoptosis increased among the cells lack of ATM expression compared with those cells that have impact ATM expression.
Gene_expression (expression) of ATM associated with apoptosis
5) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.63 Pain Relevance 0
A 25-mer AS-ODN which was previously reported to inhibit ATM expression in mouse cerebrovascular endothelial cells[17], and its associated controls, sense (Sen) and mismatch (Mis) ODNs, were synthesized by Shanghai Sangon Biological Engineering Technology & Services (Shangai, China).
Gene_expression (expression) of ATM in endothelial cells
6) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.07 Pain Relevance 0
Moreover, we found that radiation-induced apoptosis increased among the cells lack of ATM expression compared with those cells that have impact ATM expression.
Gene_expression (expression) of ATM associated with apoptosis
7) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.76 Pain Relevance 0
In the group treated with ATM AS-ODNs alone and the group irradiated in combination with the treatment of ATM AS-ODNs, the relative ATM protein expression were only 63.4 ± 5.6% and 62.1 ± 6.1% to the untreated group respectively (P < 0.05; Figure. 6).
Gene_expression (expression) of ATM
8) Confidence 0.78 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.74 Pain Relevance 0
Therefore, we manage to examine whether reduction of ATM expression after antisense oligodeoxynucleotides (AS-ODNs) treatment would result in enhanced radiosensitivity of p53-mutated SCCVII cells from C3H/He mice through the aberrant G2/M checkpoint.


Gene_expression (expression) of ATM
9) Confidence 0.68 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.44 Pain Relevance 0
From flow cytometry, we found that the cells did not accumulate in the G2/M phase following irradiation in cells transfected with ATM AS-ODNs, which mean the reduced ATM expression resulted in the defective G2/M checkpoint control.
Gene_expression (transfected) of ATM
10) Confidence 0.67 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.49 Pain Relevance 0
Studying the association between sequence variations in the ATM gene and risk of breast cancer in seven family branches [39] found no association with mutations that truncate the ATM protein in these domains.
Gene_expression (protein) of ATM associated with breast cancer
11) Confidence 0.62 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.66 Pain Relevance 0
In the group treated with ATM AS-ODNs alone and the group irradiated in combination with the treatment of ATM AS-ODNs, the relative ATM protein expression were only 63.4 ± 5.6% and 62.1 ± 6.1% to the untreated group respectively (P < 0.05; Figure. 6).
Gene_expression (expression) of ATM
12) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.75 Pain Relevance 0
We designed and synthesized AS-ODNs that target ATM mRNA to reduce the ATM expression.
Gene_expression (synthesized) of ATM mRNA
13) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2584003 Disease Relevance 0.37 Pain Relevance 0
The influence on the expression of ATM mRNA and protein in SCCVII cells were analysed by real-time quantitative PCR and western blotting respectively.
Gene_expression (expression) of ATM mRNA
14) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2584003 Disease Relevance 0.39 Pain Relevance 0
As shown in Figure. 2, ATM protein expression was also significantly reduced by ATM AS-ODNs compared with Sen-ODNs and Mis-ODNs after 72 hours treatment (Figure. 2A).
Gene_expression (expression) of ATM
15) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.16 Pain Relevance 0
In the present study, we successfully transfected ATM AS-ODNs into SCCVII cells using liposome as delivery carrier, and detected the inhibitory expression of ATM at mRNA and protein level in SCCVII cells.
Gene_expression (expression) of ATM
16) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.18 Pain Relevance 0
The potential mechanism of radiosensitization related with reduced ATM expression should be the defective G2/M cell-cycle checkpoint control and enhanced radiation-induced apoptosis.


Gene_expression (expression) of ATM in M cell associated with apoptosis
17) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.80 Pain Relevance 0
However when incubating with liposome formulations of ATM AS-ODNs, the relative ATM mRNA expression was only about 25.7 ± 3.1% to the untreated SCCVII cells, which demonstrated a significantly reduced expression of ATM mRNA (P < 0.05; Figure. 1).
Gene_expression (expression) of ATM mRNA
18) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.17 Pain Relevance 0
The relative ATM mRNA and protein expression in SCCVII cells treated with ATM AS-ODNs were decreased to 25.7 ± 3.1% and 24.1 ± 2.8% of that in untreated cells respectively (P < 0.05).
Gene_expression (expression) of ATM mRNA
19) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2584003 Disease Relevance 0.61 Pain Relevance 0
We designed and synthesized AS-ODNs that target ATM mRNA to reduce the ATM expression.
Gene_expression (expression) of ATM
20) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2584003 Disease Relevance 0.38 Pain Relevance 0

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