INT3573

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Context Info
Confidence 0.36
First Reported 1975
Last Reported 1975
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tf, Gh1) extracellular space (Tf, Gh1) extracellular region (Tf, Gh1)
endosome (Tf) cytosol (Gh1) signal transduction (Gh1)
Anatomy Link Frequency
tail 4
Tf (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 16 100.00 Very High Very High Very High
Somatostatin 20 99.90 Very High Very High Very High
Morphine 4 91.36 High High
Potency 4 90.92 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatostatin and TRF similarly inhibit PB-induced GH release.
TRF Negative_regulation (inhibit) of Localization (release) of GH associated with somatostatin
1) Confidence 0.36 Published 1975 Journal Endocrinology Section Abstract Doc Link 810343 Disease Relevance 0 Pain Relevance 0.29
These results suggest the following: 1) MS and PB act at a central nervous system (CNS) site to release GH; 2) TRF may act at a CNS site to inhibit MS- and PB-induced GH release; 3) somatostatin has direct pituitary effects on inhibition of GH, but a CNS site of action cannot be excluded; and 4) TRF stimulates tail motor activity in MS-treated rats.
TRF Negative_regulation (inhibit) of Localization (release) of GH in tail associated with somatostatin and central nervous system
2) Confidence 0.36 Published 1975 Journal Endocrinology Section Abstract Doc Link 810343 Disease Relevance 0 Pain Relevance 0.48
Somatostatin and thyrotropin-releasing factor (TRF) inhibit the in vivo release of GH induced by MS, with 50% inhibition at ca. 2.3 and 4.6 mug/100 g BW, respectively.
TRF Negative_regulation (inhibit) of Localization (release) of GH associated with somatostatin
3) Confidence 0.36 Published 1975 Journal Endocrinology Section Abstract Doc Link 810343 Disease Relevance 0 Pain Relevance 0.27
Structural analogs of TRF with low TSH-releasing activity did not inhibit GH release nor induced tail vibration in MS-treated rats.
TRF Negative_regulation (inhibit) of Localization (release) of GH in tail
4) Confidence 0.31 Published 1975 Journal Endocrinology Section Abstract Doc Link 810343 Disease Relevance 0 Pain Relevance 0.45

General Comments

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