INT35742

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.53
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ACN 1
tk (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 98.92 Very High Very High Very High
imagery 34 94.48 High High
Kinase C 2 82.40 Quite High
adenocard 2 78.88 Quite High
palliative 3 69.48 Quite High
Electroencephalography 1 60.32 Quite High
Inflammation 2 59.12 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
Nav1.7 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bardet-biedl Syndrome 8 99.24 Very High Very High Very High
Toxicity 46 98.88 Very High Very High Very High
Granuloma 12 98.60 Very High Very High Very High
Renal Cancer 4 93.36 High High
Cancer 71 90.64 High High
Metastasis 18 90.32 High High
Sprains And Strains 98 89.32 High High
Hyperplasia 4 88.72 High High
Convulsion 72 87.32 High High
Body Weight 3 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatic TK activity was significantly elevated in mice fed DEHP, BBS, or ACT at Weeks 2 and 8.
Positive_regulation (elevated) of TK associated with paracetamol and bardet-biedl syndrome
1) Confidence 0.43 Published 1988 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3206528 Disease Relevance 0.78 Pain Relevance 0.46
Persistent or transient elevation of the renal LI and TK activity accompanied renal toxicity.
Positive_regulation (elevation) of TK associated with toxicity
2) Confidence 0.43 Published 1988 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3206528 Disease Relevance 0.83 Pain Relevance 0.44
Finally, it should be noted that TK activity requires ATP.
Positive_regulation (requires) of TK
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 1.03 Pain Relevance 0.16
Ligand-binding induces autophosphorylation of the cytoplasmic domain, conformational changes, and increased TK activity.
Positive_regulation (increased) of TK
4) Confidence 0.14 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.54 Pain Relevance 0.08
Briefly, the following changes were introduced into the wild-type Scn9a (Figure 2A): the p.N641Y mutation into exon 11, the ACN positive selection vector into intron 10, and the negative TK selection vector into intron 12 (Figure 2B).
Positive_regulation (negative) of TK in ACN
5) Confidence 0.13 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.47 Pain Relevance 0.03
Ligand-binding induces autophosphorylation of the cytoplasmic domain, conformational changes, and increased TK activity.
Positive_regulation (induces) of TK
6) Confidence 0.10 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.60 Pain Relevance 0.08
In addition, the CMLV 176R gene was inserted into the TK locus of v?
Positive_regulation (inserted) of TK
7) Confidence 0.05 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.46 Pain Relevance 0
, beta-cellulin, epiregulin and amphiregulin, leads to receptor dimerization and activation of the TK.
Positive_regulation (activation) of TK
8) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880342 Disease Relevance 0.81 Pain Relevance 0.07

General Comments

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