INT35744

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Context Info
Confidence 0.46
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.52
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOB) small molecule metabolic process (MAOB) oxidoreductase activity (MAOB)
Anatomy Link Frequency
platelet 3
muscle tissues 1
developmental stages 1
MAOB (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 38 100.00 Very High Very High Very High
Nicotine 150 99.92 Very High Very High Very High
transdermal 1 99.60 Very High Very High Very High
Dismenorea 10 99.42 Very High Very High Very High
depression 84 97.56 Very High Very High Very High
withdrawal 12 96.32 Very High Very High Very High
Angina 2 95.96 Very High Very High Very High
Clonidine 2 95.88 Very High Very High Very High
sSRI 45 94.60 High High
Catecholamine 3 93.64 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 16 99.98 Very High Very High Very High
Mental Disorders 2 99.92 Very High Very High Very High
Anaerobic Bacterial Infections 6 99.52 Very High Very High Very High
Reprotox - General 1 11 99.42 Very High Very High Very High
Drug Induced Neurotoxicity 2 99.28 Very High Very High Very High
Dystonia 28 97.96 Very High Very High Very High
Parkinson's Disease 4 97.92 Very High Very High Very High
Depression 91 97.56 Very High Very High Very High
Abnormal Reflex 2 96.80 Very High Very High Very High
Overdose 11 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Drug interactions with reversible monoamine oxidase-A inhibitors.
monoamine oxidase Binding (interactions) of associated with monoamine
1) Confidence 0.46 Published 1993 Journal Clin Neuropharmacol Section Title Doc Link 8313396 Disease Relevance 0.26 Pain Relevance 0.29
Some other explanation other than MAO inhibition must be sought to explain how oral phentermine increases platelet 5-HT, since platelet MAO-B does not metabolize platelet 5-HT, and since amphetamine-type drugs are even weaker inhibitors of MAO-B than MAO-A.
MAO-B Neg (not) Binding (metabolize) of in platelet
2) Confidence 0.37 Published 1999 Journal Synapse Section Abstract Doc Link 10231134 Disease Relevance 0.16 Pain Relevance 0.11
We attempted to evaluate the biologic interconnection between premenstrual syndrome and psychiatric disorder by investigating the platelet enzyme, monoamine oxidase B.
monoamine oxidase B Binding (investigating) of in platelet associated with mental disorders, dismenorea and monoamine
3) Confidence 0.36 Published 1988 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3207130 Disease Relevance 0.79 Pain Relevance 0.57
We attempted to evaluate the biologic interconnection between premenstrual syndrome and psychiatric disorder by investigating the platelet enzyme, monoamine oxidase B.
platelet enzyme Binding (investigating) of in platelet associated with mental disorders, dismenorea and monoamine
4) Confidence 0.36 Published 1988 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3207130 Disease Relevance 0.78 Pain Relevance 0.57
In primate models of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminer-gic neurotoxicity, pretreatment with rasagiline, via MAO-B inhibition, is able to interfere with enzymatic conversion of MPTP to a potent neurotoxin, also decreasing free radical generation which would disrupt mitochondrial respiration and lead to cell death.33,34 This has previously been demonstrated in a rat model as well.35
MAO-B Neg (inhibition) Binding (inhibition) of associated with parkinson's disease, drug induced neurotoxicity and death
5) Confidence 0.34 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 1.38 Pain Relevance 0.09
Cardiac myonecrosis in hypertensive crisis associated with monoamine oxidase inhibitor therapy.
monoamine oxidase Binding (associated) of associated with pressure and volume under development, anaerobic bacterial infections and monoamine
6) Confidence 0.23 Published 1987 Journal Am. J. Med. Section Title Doc Link 3578343 Disease Relevance 1.07 Pain Relevance 0.47
Cardiac myonecrosis is a potential adverse effect of the hypertensive crisis associated with monoamine oxidase inhibitor use.
monoamine oxidase Binding (associated) of associated with pressure and volume under development, anaerobic bacterial infections and monoamine
7) Confidence 0.23 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3578343 Disease Relevance 1.03 Pain Relevance 0.49
Moclobemide inhibits MAO-A, and does not require strict dietary restrictions.39 Selegiline inhibits MAO-B, and its transdermal formulation provides several advantages compared with orally administered MAOIs, including freedom from dietary tyramine restrictions and a better adverse effect profile.37

Tricyclic antidepressants

MAO-B Binding (require) of associated with transdermal and tricyclic antidepressant
8) Confidence 0.21 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.26 Pain Relevance 0.64
In summary, our results differ from the findings of Mao and Evinger's and Quartarone et al.
Mao Binding (findings) of
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964285 Disease Relevance 0.19 Pain Relevance 0.09
It is associated with drug interactions such as the combination of monoamine oxidase inhibitors and meperidine, but may also occur with single agent therapeutic dosing or overdose of serotonergic agents.
monoamine oxidase Binding (associated) of associated with overdose and monoamine
10) Confidence 0.09 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2720377 Disease Relevance 1.49 Pain Relevance 0.57
But as the experiments with adrenalin and nicotine had shown, cells were even more sensitive to the drugs after denervation.
adrenalin Binding (experiments) of associated with nicotine
11) Confidence 0.03 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0 Pain Relevance 0.09
Langley had also performed some experiments with adrenalin, nicotine, and strychnine on chicken embryos, which showed in very early developmental stages quite marked effects and therefore did not support Elliott's suggestion.
adrenalin Binding (experiments) of in developmental stages associated with nicotine
12) Confidence 0.03 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0 Pain Relevance 0.10
Intrinsic differences in these accessory substances could explain the differences in adrenalin's efficacy on various (unstriated) muscle tissues.69
adrenalin Binding (efficacy) of in muscle tissues
13) Confidence 0.03 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.12 Pain Relevance 0.18

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