INT35745

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Context Info
Confidence 0.50
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 37
Disease Relevance 9.16
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AGL) transferase activity, transferring glycosyl groups (AGL) carbohydrate metabolic process (AGL)
cytoplasm (AGL) cytosol (AGL) hydrolase activity, acting on glycosyl bonds (AGL)
Anatomy Link Frequency
liver 6
adrenal gland 6
muscle 4
hepatocytes 2
leg muscle 2
AGL (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 98.90 Very High Very High Very High
Paracetamol 16 97.90 Very High Very High Very High
corticosteroid 2 96.40 Very High Very High Very High
Pain 23 93.92 High High
Inflammation 5 88.48 High High
Angina 2 84.60 Quite High
addiction 72 81.92 Quite High
Calcium channel 1 79.60 Quite High
Catecholamine 52 79.52 Quite High
Central nervous system 9 77.00 Quite High
Disease Link Frequency Relevance Heat
Disease 64 100.00 Very High Very High Very High
Glycogen Storage Disease Type V 2 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 99.96 Very High Very High Very High
Necrosis 7 99.56 Very High Very High Very High
Stress 356 99.54 Very High Very High Very High
Hypothermia 51 99.26 Very High Very High Very High
Coronary Heart Disease 34 99.16 Very High Very High Very High
Myocardial Infarction 3 98.98 Very High Very High Very High
Cv Unclassified Under Development 3 98.90 Very High Very High Very High
Glycogen Storage Disease 21 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mc Ardle's disease is a genetic glycogenosis characterized by the accumulation of glycogen in skeletal muscle secondary to the deficiency of muscle glycogen phosphorylase.
Negative_regulation (deficiency) of glycogen in skeletal muscle associated with glycogen storage disease and disease
1) Confidence 0.50 Published 2002 Journal Rev Med Suisse Romande Section Abstract Doc Link 12522938 Disease Relevance 0.98 Pain Relevance 0.09
After reperfusion, the majority of the patients had progressive changes of ischemia, with marked mitochondrial and sarcotubular swelling, depletion of glycogen, chromatin clumping, and myofibrillar disruption; amorphous mitochondrial densities were occasionally seen.
Negative_regulation (depletion) of glycogen associated with pressure and volume under development and ischemia
2) Confidence 0.24 Published 1988 Journal Am J Cardiovasc Pathol Section Abstract Doc Link 3207491 Disease Relevance 0.46 Pain Relevance 0.26
When administered to mice after experimental acetaminophen overdose, cimetidine generally prevented the development of centrilobular necrosis, but did not prevent loss of glycogen or appearance of fat in the hepatocytes.
Negative_regulation (loss) of glycogen in hepatocytes associated with necrosis, paracetamol and overdose
3) Confidence 0.24 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 7244370 Disease Relevance 0.37 Pain Relevance 0.36
During 3 hr after the drug administration brain tissue demonstrated the decreased glycogen content and particular, drastically reduced the drug action.
Negative_regulation (decreased) of glycogen in brain
4) Confidence 0.22 Published 1980 Journal Farmakol Toksikol Section Abstract Doc Link 7439366 Disease Relevance 0.09 Pain Relevance 0.18
In the case of a marathon runner, one first applies Equation 5 to compute , the distance to ‘the wall’ (glycogen depletion) for the runner in question given his or her physiologic parameters and intended pace.
Negative_regulation (depletion) of glycogen
5) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
Ingested carbohydrate is useful only to the extent that it becomes available to the working muscles before the onset of glycogen depletion.
Negative_regulation (depletion) of glycogen in muscles
6) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.06 Pain Relevance 0.04
This biochemical feedback network forestalls complete glycogen depletion, but simultaneously decreases the energy efficiency of oxygen utilization.
Negative_regulation (depletion) of glycogen
7) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.09 Pain Relevance 0
Such schedules are designed to induce a ‘glycogen supercompensation’ effect, whereby glycogen depletion and carbohydrate restriction stimulate increased expression of glycogen synthase in the depleted muscle fibers, enhancing their ability to synthesize glycogen during the final, high-carbohydrate-diet phase, permitting muscle fibers to store glycogen in supranormal concentrations.
Negative_regulation (depletion) of glycogen in muscle fibers
8) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.06 Pain Relevance 0
Experimental evidence also suggests that midrace fueling extends endurance capacity by increasing the proportion of oxidized carbohydrate derived from plasma glucose as opposed to intramuscular glycogen [31], and correspondingly reducing the rate of intramuscular glycogen depletion [32].
Negative_regulation (depletion) of glycogen in plasma
9) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
In particular, assuming that runners consumed no exogenous carbohydrate during the races, the mean ratio of model-predicted to experimentally observed decrease in leg muscle glycogen density is (standard error); under the opposite assumption that runners consumed the maximum allowable amount of exogenous carbohydrate during the races, the mean ratio of modeled to predicted change in glycogen density is .
Negative_regulation (decrease) of glycogen in leg muscle
10) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
However, because the latter two parameters contribute as a product, relative decreases in one can be offset by inversely proportional increases in the other, so many different sets of physical parameters can result in glycogen depletion at a particular distance.
Negative_regulation (depletion) of glycogen
11) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
In the context of endurance runners seeking to avoid ‘hitting the wall,’ the modeling approach presented here can be used to compute the amount of carbohydrate a given runner must consume en route in order to ‘push back the wall’ a given distance (beyond, for example, the end of a marathon) and avoid complete glycogen depletion during the race.
Negative_regulation (depletion) of glycogen
12) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.21 Pain Relevance 0.04
As discussed in detail in the Methods section, where Equation 5 is derived to express the distance, , an athlete can run before ‘hitting the wall,’ declines with increasing levels of exertion (), and with decreases in relative leg muscle mass or leg muscle glycogen density.
Negative_regulation (decreases) of glycogen in leg muscle
13) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
Recently, sudden cardiac death has been reported in a child with muscle-specific glycogen synthase deficiency [152].
Negative_regulation (deficiency) of glycogen in muscle associated with myocardial infarction
14) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.56 Pain Relevance 0
Glycogen Storage Disease Type V (McArdle Disease; Deficiency of Muscle Phosphorylase)

PathophysiologyMyophosphorylase activity is deficient in McArdle disease (OMIM 232600); the disorder is inherited as an autosomal recessive trait.

Negative_regulation (deficient) of Glycogen in Muscle associated with glycogen storage disease type v and disease
15) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.62 Pain Relevance 0
Before reporting at the laboratory on the day of glycogen depletion, the subjects consumed a prepackaged standardized meal regulated to body weight and activity level (23), with 77% energy (%E) carbohydrate, 10E% protein, and 13%E fat.
Negative_regulation (depletion) of glycogen in fat associated with body weight
16) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.10 Pain Relevance 0
After the glycogen depletion, they were given a dinner low in carbohydrates (1%E carbohydrate, 26%E protein, and 73%E fat) to prevent muscle glycogen resynthesis.
Negative_regulation (depletion) of glycogen in fat
17) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.07 Pain Relevance 0
As previously suggested, such a glycogen-dependent regulation of gene expression may take place through glycogen regulatory enzymes such as protein phosphatase 1 (PP1) and glycogen synthase kinase 3 (GSK3), which are bound to the glycogen scaffold, but released when the glycogen content decreases (15).
Negative_regulation (decreases) of glycogen
18) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
In this study, we aimed to evaluate the effects of two different types of stress agents on lipid depletion in the adrenal gland and on glycogen depletion in the liver.


Negative_regulation (depletion) of glycogen in liver associated with stress
19) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845770 Disease Relevance 0.60 Pain Relevance 0
Furthermore, we noted that the electrical countershock significantly increased lipid depletion in the adrenal gland and glycogen depletion in the liver.
Negative_regulation (depletion) of glycogen in liver
20) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2845770 Disease Relevance 0.31 Pain Relevance 0

General Comments

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