INT35780

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Context Info
Confidence 0.55
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 4.90
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mt1a) nucleus (Mt1a) intracellular (Mt1a)
lysosome (Mt1a) cytoplasm (Mt1a)
Anatomy Link Frequency
neuronal 1
MT2 1
bile duct 1
blood vessels 1
liver 1
Mt1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 360 100.00 Very High Very High Very High
Anterior cingulate cortex 445 99.92 Very High Very High Very High
lidocaine 185 99.82 Very High Very High Very High
Paracetamol 9 99.80 Very High Very High Very High
amygdala 10 98.04 Very High Very High Very High
Bile 4 97.16 Very High Very High Very High
Pain 96 93.12 High High
depression 26 92.68 High High
antidepressant 36 89.56 High High
Central nervous system 7 87.52 High High
Disease Link Frequency Relevance Heat
Nociception 155 99.28 Very High Very High Very High
Hepatitis 2 96.72 Very High Very High Very High
Sprains And Strains 2 95.00 High High
Pain 96 93.12 High High
Depression 36 92.68 High High
Anxiety Disorder 32 92.08 High High
Plasmacytoma 4 85.96 High High
Multiple Myeloma 1 77.08 Quite High
Syndrome 2 74.96 Quite High
Shock 30 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated levels of melatonin activate the MT1 and MT2 receptors.
Positive_regulation (activate) of MT1 in MT2
1) Confidence 0.55 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655086 Disease Relevance 0.42 Pain Relevance 0.28
Activation of MT1 receptors in the suprachiasmatic nucleus appears to inhibit neuronal firing and facilitate sleep, while activation of MT2 receptors phase shift circadian rhythms (Dubocovich 2006).
Positive_regulation (Activation) of MT1 in neuronal
2) Confidence 0.55 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655086 Disease Relevance 0.43 Pain Relevance 0.22
The accumulation, accompanied by marked induction of metallothionein (MT), is believed to be due to the inherent lack of output of Cu into the bile duct and blood vessels.
Positive_regulation (induction) of MT in blood vessels associated with bile
3) Confidence 0.39 Published 1997 Journal Toxicology Section Abstract Doc Link 9160108 Disease Relevance 0.19 Pain Relevance 0.11
Induction of hepatic metallothionein (MT) by acetaminophen was characterized in the rat and mouse.
Positive_regulation (Induction) of MT associated with paracetamol
4) Confidence 0.18 Published 1988 Journal Toxicology Section Abstract Doc Link 3212790 Disease Relevance 0 Pain Relevance 0.26
Treatment of rats with the hepatotoxin resulted in increase of liver MT in a dose-dependent manner.
Positive_regulation (increase) of MT in liver
5) Confidence 0.18 Published 1988 Journal Toxicology Section Abstract Doc Link 3212790 Disease Relevance 0 Pain Relevance 0.26
MT concentration was elevated by 41%, 140% and 260% following acetaminophen injection at doses of 250, 500 and 1000 mg/kg, respectively.
Positive_regulation (elevated) of MT associated with paracetamol
6) Confidence 0.18 Published 1988 Journal Toxicology Section Abstract Doc Link 3212790 Disease Relevance 0 Pain Relevance 0.27
The accumulation, accompanied by marked induction of metallothionein (MT), is believed to be due to the inherent lack of output of Cu into the bile duct and blood vessels.
Positive_regulation (induction) of MT in bile duct associated with bile
7) Confidence 0.13 Published 1997 Journal Toxicology Section Abstract Doc Link 9160108 Disease Relevance 0.19 Pain Relevance 0.11
Lesions of the MT blocked inhibitory avoidance, both 30 s and 24 h after footshock training, and suggest that the MT is required for inhibitory avoidance information processing.
Positive_regulation (required) of MT associated with thalamus
8) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.60 Pain Relevance 0.77
Another possible explanation is that inactivation of the MT interrupts the consolidation of nociceptive memory.
Positive_regulation (inactivation) of MT associated with nociception and thalamus
9) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.65 Pain Relevance 1.01
The present study did not include pretraining lidocaine infusions because lidocaine-induced inactivation of the MT can last for approximately 30 min.
Positive_regulation (inactivation) of MT associated with thalamus and lidocaine
10) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.48 Pain Relevance 0.97
We have shown that short-term plasticity, such as paired-pulse facilitation, is evoked in the ACC by stimulation of the MT, suggesting that nociceptive information in the MT is transmitted to the ACC, and this may act to mediate short-term nociceptive information processing [26-29].
Positive_regulation (stimulation) of MT associated with nociception, thalamus and anterior cingulate cortex
11) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.68 Pain Relevance 0.82
Electrical stimulation of the MT has been shown to evoke neural responses in the amygdala, an area implicated in emotional memory formation [25].
Positive_regulation (stimulation) of MT in amygdala associated with thalamus and amygdala
12) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.79 Pain Relevance 0.93
Immunohistochemical staining was positive for CD45 (LCA), CD56 (N-CAM), CD43 (MT1), and cytokeratin CAM5.2.
Positive_regulation (positive) of MT1
13) Confidence 0.06 Published 2001 Journal J. Histochem. Cytochem. Section Abstract Doc Link 11373326 Disease Relevance 0.47 Pain Relevance 0.09

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