INT35786

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Context Info
Confidence 0.33
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
mu opioid receptor 8 100.00 Very High Very High Very High
Opioid 1 92.56 High High
Neurotransmitter 1 72.60 Quite High
addiction 1 64.32 Quite High
Disease Link Frequency Relevance Heat
Infection 5 100.00 Very High Very High Very High
Repression 2 100.00 Very High Very High Very High
Neuroblastoma 2 76.44 Quite High
Immunodeficiency 3 75.00 Quite High
Syndrome 1 57.04 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 5.00 Very Low Very Low Very Low
Morphine Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The repression of the MOR gene secondary to SIVmac239 infection could be abolished by the demethylating agent 5-aza-2'-deoxycytidine.
Negative_regulation (abolished) of Negative_regulation (repression) of MOR gene associated with repression, mu opioid receptor and infection
1) Confidence 0.33 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.76 Pain Relevance 0.44
Pretreatment of cells with PT overnight reduced the inhibitory effects of both MOR and OXO.
Negative_regulation (reduced) of Negative_regulation (reduced) of MOR associated with morphine
2) Confidence 0.26 Published 1988 Journal Brain Res. Section Abstract Doc Link 3214736 Disease Relevance 0.15 Pain Relevance 0.66

General Comments

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