INT35788

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Context Info
Confidence 0.06
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.66
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gpx3) oxidoreductase activity (Gpx3) extracellular region (Gpx3)
Anatomy Link Frequency
neurons 2
lung 1
CNS 1
peripheral neurons 1
Gpx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
Pain 35 98.32 Very High Very High Very High
Central nervous system 10 97.80 Very High Very High Very High
antagonist 6 91.40 High High
spinal dorsal horn 6 90.80 High High
nMDA receptor antagonist 4 88.40 High High
tetrodotoxin 6 84.96 Quite High
nMDA receptor 3 77.92 Quite High
Spinal cord 11 72.72 Quite High
gABA 3 72.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 19 100.00 Very High Very High Very High
Fibrosis 17 100.00 Very High Very High Very High
Pain 43 98.32 Very High Very High Very High
Nociception 28 86.92 High High
Neuropathic Pain 79 50.00 Quite Low
Hyperplasia 2 45.44 Quite Low
Nervous System Injury 28 16.80 Low Low
Demyelinating Disease 31 5.00 Very Low Very Low Very Low
Injury 17 5.00 Very Low Very Low Very Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results open for investigation the role of extracellular protein phosphorylation systems in processes underlying the responsiveness of CNS neurons to secreted ATP.
Phosphorylation (phosphorylation) of extracellular in CNS associated with central nervous system
1) Confidence 0.06 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3214751 Disease Relevance 0 Pain Relevance 0.23
The significant role of secreted ATP in the regulation of neuronal function and the activity of ecto-protein kinases which utilize extracellular ATP to phosphorylate proteins localized at the cell surface have been previously studied in peripheral neurons and in cloned neural cell lines.
Phosphorylation (phosphorylate) of extracellular in peripheral neurons
2) Confidence 0.06 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3214751 Disease Relevance 0 Pain Relevance 0.10
ATP secretion and extracellular protein phosphorylation by CNS neurons in primary culture.
Phosphorylation (phosphorylation) of extracellular in neurons
3) Confidence 0.06 Published 1988 Journal Brain Res. Bull. Section Title Doc Link 3214751 Disease Relevance 0 Pain Relevance 0.17
This table is organized into biological functions that are prevalent during lung regeneration including cell cycle/cell division, DNA synthesis or repair, cell proliferation, extracellular matrix, cytoskeleton, inflammatory, fibrotic, and immune responses, and protein phosphorylation, and miscellaneous biological functions.
Phosphorylation (phosphorylation) of extracellular in lung associated with fibrosis and inflammation
4) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.20 Pain Relevance 0.08
The characteristics of pain behavior were consistent to those obtained with the measurement of neuron-specific phosphorylation of extracellular signal-regulated kinase 1/2 (p-ERK).
Phosphorylation (phosphorylation) of extracellular in neuron associated with pain
5) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.46 Pain Relevance 0.94

General Comments

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