INT3579

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 555
Total Number 574
Disease Relevance 43.35
Pain Relevance 292.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
neurohypophysis 48
neural lobe 29
supraoptic nucleus 28
blood 24
neurons 23
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1444 100.00 Very High Very High Very High
antagonist 1182 100.00 Very High Very High Very High
agonist 707 100.00 Very High Very High Very High
Opioid 623 100.00 Very High Very High Very High
Enkephalin 276 100.00 Very High Very High Very High
Cholecystokinin 194 100.00 Very High Very High Very High
Neuropeptide 193 100.00 Very High Very High Very High
noradrenaline 159 100.00 Very High Very High Very High
anesthesia 67 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 13 100.00 Very High Very High Very High
Natriuresis 28 99.84 Very High Very High Very High
Stress 367 99.82 Very High Very High Very High
Volume Depletion And Dehydration 90 99.68 Very High Very High Very High
Hyperalgesia 6 99.62 Very High Very High Very High
Pain 142 99.58 Very High Very High Very High
Opiate Addiction 14 99.52 Very High Very High Very High
Cocaine Dependence 4 99.52 Very High Very High Very High
Pressure Volume 2 Under Development 30 99.48 Very High Very High Very High
Morphine Dependence 36 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intragranular colocalization of immunoreactive methionine-enkephalin and oxytocin within the nerve terminals in the posterior pituitary.
Localization (colocalization) of oxytocin in posterior pituitary associated with enkephalin
1) Confidence 0.81 Published 1985 Journal J. Histochem. Cytochem. Section Title Doc Link 4020100 Disease Relevance 0 Pain Relevance 0.33
Late pregnant rats exhibit endogenous opioid restraint of oxytocin cells since i.v. naloxone (NLX opioid antagonist) increases oxytocin (OXT) secretion but OXT nerve terminals become desensitised to opioids.
Localization (secretion) of oxytocin in nerve associated with antagonist, narcan, endogenous opioid and opioid
2) Confidence 0.81 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542430 Disease Relevance 0 Pain Relevance 0.66
Late pregnant rats exhibit endogenous opioid restraint of oxytocin cells since i.v. naloxone (NLX opioid antagonist) increases oxytocin (OXT) secretion but OXT nerve terminals become desensitised to opioids.
Localization (secretion) of OXT in nerve associated with antagonist, narcan, endogenous opioid and opioid
3) Confidence 0.81 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542430 Disease Relevance 0 Pain Relevance 0.66
The influence of naloxone on the release in limbic brain areas of both oxytocin (OXT) and vasopressin, measured by radioimmunoassay, was studied in conscious parturient rats.
Localization (release) of oxytocin in brain associated with narcan
4) Confidence 0.81 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1784342 Disease Relevance 0.07 Pain Relevance 0.22
Naloxone increases the release of oxytocin, but not vasopressin, within limbic brain areas of conscious parturient rats: a push-pull perfusion study.
Localization (release) of oxytocin in brain associated with narcan
5) Confidence 0.81 Published 1991 Journal Neuroendocrinology Section Title Doc Link 1784342 Disease Relevance 0.08 Pain Relevance 0.42
Serotonergic control of oxytocin release during suckling in the rat: opposite effects in conscious and anesthetized rats.
Localization (release) of oxytocin associated with anesthesia
6) Confidence 0.80 Published 1983 Journal Neuroendocrinology Section Title Doc Link 6223233 Disease Relevance 0.09 Pain Relevance 0.23
This observation indicates liberation of an endogenous opioid, during stimulation of the neurohypophysis, leading to inhibition of the oxytocin secretion.
Localization (secretion) of oxytocin in neurohypophysis associated with endogenous opioid
7) Confidence 0.80 Published 1988 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2848232 Disease Relevance 0.09 Pain Relevance 0.69
Relaxin inhibited oxytocin release in a dose-dependent manner and the onset of inhibition occurred within 6-10 min and lasted for 10-60 min.
Localization (release) of oxytocin
8) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.22
Oxytocin release during parturition in the pelvic-neurectomized rat.
Localization (release) of Oxytocin
9) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Title Doc Link 3711758 Disease Relevance 0.13 Pain Relevance 0.06
The effect of relaxin on electrically evoked release of oxytocin from the posterior pituitary was examined by monitoring changes in intramammary pressure in the anaesthetized lactating rat.
Localization (release) of oxytocin in posterior pituitary
10) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0
These findings suggest the possibility that oxytocin released from the fetal hypothalamus is involved in parturition.
Localization (released) of oxytocin in hypothalamus
11) Confidence 0.80 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18550792 Disease Relevance 0.34 Pain Relevance 0.46
Relaxin (500-2000 ng/ml) failed to inhibit oxytocin release in vitro.
Localization (release) of oxytocin
12) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.39
The neurohypophysis is known to contain endogenous opioid peptides, therefore the effect of relaxin on electrically stimulated release of oxytocin from the rat isolated neural lobe in vitro was examined.
Localization (release) of oxytocin in neural lobe associated with endogenous opioid
13) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.39
Effects of porcine relaxin on oxytocin release from the neurohypophysis in the anaesthetized lactating rat.
Localization (release) of oxytocin in neurohypophysis associated with narcan
14) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Title Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.25
The results suggest that relaxin can inhibit the release of oxytocin from terminals in the neurohypophysis, but by an indirect mechanism.
Localization (release) of oxytocin in neurohypophysis
15) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.39
During the period of inhibition, i.v. injection of the opioid antagonist naloxone chloride (1 mg/kg) completely and immediately restored electrically evoked oxytocin release.
Localization (release) of oxytocin associated with antagonist, narcan and opioid
16) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.38
They are unlikely to be of neurohypophysial origin and may probably come from the adrenal medulla, since acute adrenalectomy negated the inhibitory effect of relaxin on oxytocin release.
Localization (release) of oxytocin in adrenal medulla associated with medulla
17) Confidence 0.80 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3755459 Disease Relevance 0 Pain Relevance 0.35
Evidence also exists for fetal oxytocin release just before and during parturition.
Localization (release) of oxytocin
18) Confidence 0.80 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18550792 Disease Relevance 0.21 Pain Relevance 0.32
Thus, systemic IL-1beta acts centrally to increase oxytocin secretion.
Localization (secretion) of oxytocin
19) Confidence 0.80 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553786 Disease Relevance 0 Pain Relevance 0.62
These data indicate that oxytocin can be released by stimulation of peripheral nerves originating in the skin and/or muscle and in the gastrointestinal tract and thus these organs may be involved in the control of oxytocin secretion.
Localization (secretion) of oxytocin in muscle
20) Confidence 0.80 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3223304 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox