INT35801

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Context Info
Confidence 0.38
First Reported 1988
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 34
Total Number 37
Disease Relevance 20.88
Pain Relevance 12.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 4
T cells 2
parenchyma 2
embryos 1
macrophages 1
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 8 99.92 Very High Very High Very High
Central nervous system 445 99.76 Very High Very High Very High
Inflammation 188 99.68 Very High Very High Very High
Pain 27 99.68 Very High Very High Very High
IPN 18 99.68 Very High Very High Very High
Morphine 46 99.48 Very High Very High Very High
Neuropeptide 52 99.34 Very High Very High Very High
adenocard 9 99.34 Very High Very High Very High
diclofenac 20 98.96 Very High Very High Very High
Spinal cord 85 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 55 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 15 99.84 Very High Very High Very High
INFLAMMATION 263 99.68 Very High Very High Very High
Inflammatory Pain 18 99.68 Very High Very High Very High
Pain 16 99.68 Very High Very High Very High
Autoimmune Disease 91 99.46 Very High Very High Very High
Disease 272 99.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 336 99.20 Very High Very High Very High
Diabetes Mellitus 3 99.18 Very High Very High Very High
Infection 158 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies on animal models have shown that diseases of the periphery, such as diabetes and inflammatory pain, have deleterious effects on the BBB which may contribute to neurological complications associated with these conditions.
Regulation (effects) of BBB associated with diabetes mellitus, ipn and disease
1) Confidence 0.38 Published 2008 Journal Curr. Top. Dev. Biol. Section Abstract Doc Link 17950377 Disease Relevance 0.79 Pain Relevance 0.35
BBB alteration was measured by infusing 2% Evans blue dye.
Regulation (alteration) of BBB
2) Confidence 0.24 Published 1988 Journal J. Neurosci. Methods Section Abstract Doc Link 3216678 Disease Relevance 0 Pain Relevance 0.09
The present studies demonstrate that P-gp function at the BBB can be modulated by rifampin in a dose- and concentration-dependent manner.
Regulation (modulated) of BBB
3) Confidence 0.22 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721332 Disease Relevance 0 Pain Relevance 0.07
General anesthetic agents can alter the BBB function.
Regulation (alter) of BBB
4) Confidence 0.20 Published 2003 Journal Masui Section Abstract Doc Link 13677273 Disease Relevance 0.48 Pain Relevance 0.36
The primary BBB/BSCB function is control of the CNS homeostasis by selective transport of molecules and cells from the systemic compartment.
Regulation (control) of BBB associated with central nervous system
5) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.67 Pain Relevance 0.20
The rate of delivery (which is dependent on the permeability of the BBB) must be considered separately from the extent of equilibration of the drug across the BBB and the intra-brain distribution data in order to fully understand brain drug delivery and its consequences for central drug action.
Regulation (dependent) of BBB in brain
6) Confidence 0.13 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.03
In the present study, the transport of p97 across the BBB without altering BBB permeability was confirmed using microscopy (Figure 5).
Neg (without) Regulation (altering) of BBB
7) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.07 Pain Relevance 0.08
Virchow–Robin spaces (VRS) are perivascular compartments surrounding small vessels within the CNS which contribute to BBB and BSB integrity and modulate immune responses.90 VRS contain microglia and these cells are known to be influenced by PACAP and VIP in immunoregulation.8 Autoimmunity of these VNs or their receptors would be expected to affect BBB/BSB and VRS function and therefore may contribute to the etiology of neuropsychiatric-related neurodegenerative and other conditions by affecting CNS and immunological homeostasis.
Regulation (affect) of BBB in vessels associated with autoimmune disease, neuropeptide, central nervous system and neurodegenerative disease
8) Confidence 0.10 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.45 Pain Relevance 0.39
These safer biochemical techniques selectively disrupt the intratumoral BBB while minimally altering the normal BBB 45.
Regulation (altering) of BBB
9) Confidence 0.09 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0.54 Pain Relevance 0.16
Peptides influence the passage of glucose, amino acids, and inorganic acids and may affect the integrity of the BBB.
Spec (may) Regulation (affect) of BBB
10) Confidence 0.08 Published 1988 Journal Am. J. Med. Sci. Section Abstract Doc Link 3287919 Disease Relevance 0.18 Pain Relevance 0.08
Moreover, they provide the first evidence of a pharmacological effect specifically enabled by controlled (i.e., receptor-mediated) modulation of the BBB.
Regulation (modulation) of BBB
11) Confidence 0.08 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729419 Disease Relevance 0.09 Pain Relevance 0.93
Therefore, in the present study we explored the influence of both coplanar and noncoplanar PCBs on molecular and functional properties of the BBB.
Regulation (influence) of BBB
12) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.66 Pain Relevance 0.13
Alterations in the BBB to protein tracers were seen in several regions of the brain.
Regulation (Alterations) of BBB in brain
13) Confidence 0.06 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105918 Disease Relevance 0.56 Pain Relevance 0.78
These observations suggest that psychostimulants and associated stress are capable to influence the brain function, probably through modifying the BBB function, not reported earlier.
Neg (not) Regulation (modifying) of BBB in brain associated with stress
14) Confidence 0.06 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105918 Disease Relevance 0.46 Pain Relevance 0.53
Recent studies have demonstrated significant modulation of the BBB in a number of diseases and physiological states, including pain.
Regulation (modulation) of BBB associated with pain and disease
15) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305016 Disease Relevance 0.42 Pain Relevance 0.41
These studies demonstrate the complex regulation of the BBB occurring during inflammatory pain and the role of COX in this process.
Regulation (regulation) of BBB associated with ipn
16) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305016 Disease Relevance 0.48 Pain Relevance 0.73
An understanding of BBB regulation during pain states is critically important for pharmacotherapy, and it holds great promise for new therapies to treat central nervous system pathologies.
Regulation (regulation) of BBB in central nervous system associated with pain and central nervous system
17) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305016 Disease Relevance 0.37 Pain Relevance 0.67
It describes the role of cyclooxygenase (COX) up-regulation by blocking with diclofenac (30 mg/kg, i.p.), and it examines the variation in BBB regulation through various brain regions.
Spec (examines) Regulation (regulation) of BBB in brain associated with diclofenac
18) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305016 Disease Relevance 0.46 Pain Relevance 0.54
were introduced on the abluminal side of the BBB in the brain parenchyma, an additional enhanced cell infiltration and more pronounced disruption of the BBB ensued.
Regulation (introduced) of BBB in parenchyma
19) Confidence 0.06 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.84 Pain Relevance 0.12
Our limited knowledge of the nature of these signals and of the molecular regulation of the BBB hampers the development of BBB model systems and patient therapy (Liebner et al., 2000b; Engelhardt, 2006).
Regulation (regulation) of BBB
20) Confidence 0.05 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0.18 Pain Relevance 0.05

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