INT35802

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 23
Disease Relevance 21.50
Pain Relevance 7.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
nerve 4
neurons 2
Treg 2
brain 1
paraventricular thalamic nucleus 1
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 136 100.00 Very High Very High Very High
Somatostatin 2 99.72 Very High Very High Very High
cytokine 154 99.70 Very High Very High Very High
Neuropeptide 141 99.34 Very High Very High Very High
Central nervous system 232 99.32 Very High Very High Very High
Arthritis 54 99.20 Very High Very High Very High
5HT 1 98.12 Very High Very High Very High
Inflammation 1042 98.08 Very High Very High Very High
adenocard 32 97.84 Very High Very High Very High
Crohn's disease 200 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1078 99.52 Very High Very High Very High
Convulsion 24 99.52 Very High Very High Very High
Arthritis 64 99.20 Very High Very High Very High
Colitis 480 98.56 Very High Very High Very High
Inflammatory Bowel Disease 768 98.48 Very High Very High Very High
Diarrhoea 32 98.40 Very High Very High Very High
Pressure Volume 2 Under Development 8 97.88 Very High Very High Very High
Disease 468 97.76 Very High Very High Very High
Fatigue 88 97.64 Very High Very High Very High
Multiple Sclerosis 224 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A detailed time-course study revealed that seizures in El mice caused (1) significant decreases in levels of ME-LI in the striatum and hippocampus during seizures, (2) a significant decrease of VIP-LI content in the striatum 3 hours after seizures, and (3) a significant increase in hypothalamic VIP-LI 9 hours after seizures.
Positive_regulation (increase) of VIP in striatum associated with convulsion, hippocampus and enkephalin
1) Confidence 0.40 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 3216955 Disease Relevance 0.98 Pain Relevance 0.71
PACAP and VIP, as potent activators of adenylate cyclase (AC), have a key role in cyclic adenosine monophosphate (cAMP) production affecting regulatory T cell (Treg) and other immune functions.
Positive_regulation (activators) of VIP in Treg associated with adenocard
2) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2695238 Disease Relevance 0.77 Pain Relevance 0.48
PACAP and VIP, as potent activators of adenylate cyclase (AC), have a key role in cyclic adenosine monophosphate (cAMP) production affecting BBB/BSB function along with regulatory T cell (Treg) and other immune functions.
Positive_regulation (activators) of VIP in regulatory T cell associated with adenocard
3) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.00 Pain Relevance 0.22
PACAP and VIP are widely distributed in the central (CNS) and peripheral (PNS) including autonomic (ANS) nervous systems and peripheral tissues including heart, lung, pancreas, adrenal gland, gonads, and gastrointestinal tract as well as immune cells and lymphatic system.5,103 PACAP and VIP have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, and immune and nociception modulators.
Positive_regulation (distributed) of VIP in lung associated with nociception, neurotransmitter, hypoxia and central nervous system
4) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.57 Pain Relevance 0.23
Many regulatory and antiinflammatory functions of PACAP and VIP are dependent on the Th2-directed cytokines93 eg, interleukin-10 (IL-10) and IL-4 and these could be compromised in PACAP/VIP failure.
Positive_regulation (dependent) of VIP associated with inflammation
5) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.79 Pain Relevance 0.10
Although in VIP treated mice OPG mRNA levels were slightly increased, a seven-fold drop in the RANKL/OPG ratio was observed (Table 3).
Positive_regulation (increased) of VIP
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 1.03 Pain Relevance 0.41
Fibers projecting from SCN neurons that are immunoreactive for AVP and VIP exhibit a characteristic morphology, and project to the lateral septum, a series of medial hypothalamic areas extending from the preoptic to the posterior hypothalamic area and to the paraventricular thalamic nucleus.
Positive_regulation (immunoreactive) of VIP in paraventricular thalamic nucleus
7) Confidence 0.32 Published 2001 Journal Brain Res. Section Abstract Doc Link 11597605 Disease Relevance 0.08 Pain Relevance 0.27
In vivo, microinjection of VIP into the SCN region resets rodent behavioral rhythms (Piggins et al. 1995), while in vitro applications of exogenous VIP to SCN brain slices shifts rhythms in neurophysiological activity (Reed et al. 2001) and AVP release (Watanabe et al. 2000).
Positive_regulation (microinjection) of VIP in brain
8) Confidence 0.25 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2658715 Disease Relevance 0.08 Pain Relevance 0.04
Kishimoto et al. reported an increased VIP immunoreactivity in neurons and nerve fibers in both plexuses of the colon and an elevated content of VIP in dextran sulfate sodium (DSS)-induced colitis in rats [51].
Positive_regulation (increased) of VIP in nerve associated with colitis
9) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.69 Pain Relevance 0.37
A similar increase in VIP concentration was also evident in rectal biopsies from CD, but not UC, patients.
Positive_regulation (increase) of VIP associated with inflammatory bowel disease and crohn's disease
10) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.53 Pain Relevance 0.29
Significant increases in VIP content of colonic nerves have been reported in biopsies from CD patients compared to UC patients or controls [50].
Positive_regulation (increases) of VIP in nerves associated with inflammatory bowel disease and crohn's disease
11) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.36 Pain Relevance 0.27
These include depletion of the enzyme FRAP and the peptides SP, CCK, somatostatin, CGRP and an increase of VIP.
Positive_regulation (increase) of VIP associated with somatostatin
12) Confidence 0.15 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3310519 Disease Relevance 0 Pain Relevance 0.69
A detailed time-course study revealed that seizures in El mice caused (1) significant decreases in levels of ME-LI in the striatum and hippocampus during seizures, (2) a significant decrease of VIP-LI content in the striatum 3 hours after seizures, and (3) a significant increase in hypothalamic VIP-LI 9 hours after seizures.
Positive_regulation (increase) of VIP in hippocampus associated with convulsion, hippocampus and enkephalin
13) Confidence 0.14 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 3216955 Disease Relevance 0.98 Pain Relevance 0.71
PACAP and VIP are widely distributed in the central (CNS) and peripheral (PNS) including autonomic (ANS) nervous systems and peripheral tissues including heart, lung, pancreas, adrenal gland, gonads, and gastrointestinal tract as well as immune cells and lymphatic system.5,103 PACAP and VIP have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, and immune and nociception modulators.
Positive_regulation (distributed) of VIP in heart associated with nociception, neurotransmitter, hypoxia and central nervous system
14) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.57 Pain Relevance 0.23
PACAP and VIP are widely distributed in the central (CNS) and peripheral (PNS) including autonomic (ANS) nervous systems and peripheral tissues including heart, lung, pancreas, adrenal gland, gonads, and gastrointestinal tract as well as immune cells and lymphatic system.5,103 PACAP and VIP have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, and immune and nociception modulators.
Positive_regulation (distributed) of VIP in gonads associated with nociception, neurotransmitter, hypoxia and central nervous system
15) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.57 Pain Relevance 0.23
PACAP and VIP are widely distributed in the central (CNS) and peripheral (PNS) including autonomic (ANS) nervous systems and peripheral tissues including heart, lung, pancreas, adrenal gland, gonads, and gastrointestinal tract as well as immune cells and lymphatic system.5,103 PACAP and VIP have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, and immune and nociception modulators.
Positive_regulation (distributed) of VIP in adrenal gland associated with nociception, neurotransmitter, hypoxia and central nervous system
16) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.57 Pain Relevance 0.23
PACAP and VIP are widely distributed in the central (CNS) and peripheral (PNS) including autonomic (ANS) nervous systems and peripheral tissues including heart, lung, pancreas, adrenal gland, gonads, and gastrointestinal tract as well as immune cells and lymphatic system.5,103 PACAP and VIP have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, and immune and nociception modulators.
Positive_regulation (distributed) of VIP in pancreas associated with nociception, neurotransmitter, hypoxia and central nervous system
17) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.57 Pain Relevance 0.23
Kishimoto et al. reported an increased VIP immunoreactivity in neurons and nerve fibers in both plexuses of the colon and an elevated content of VIP in dextran sulfate sodium (DSS)-induced colitis in rats [51].
Positive_regulation (increased) of VIP in nerve associated with colitis
18) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.80 Pain Relevance 0.44
In addition to SP and VIP, mRNA for a number of peptides is increased in colon tissues from mice undergoing experimental colitis induced by oil of mustard (OM; allyl isothiocyanate), a direct stimulant of small nerve fibers and a potent, acute inflammatory irritant.
Positive_regulation (increased) of VIP in nerve associated with colitis, inflammation and substance p
19) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.65 Pain Relevance 0.61
Lymphocytes express receptors for neuropeptides released by enteric nerves, and stimulation of these cells with SP or VIP can induce their differentiation and alter their production of immunoglobulins.
Positive_regulation (stimulation) of VIP in Lymphocytes associated with neuropeptide and substance p
20) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.48 Pain Relevance 0.28

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