INT35811

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Context Info
Confidence 0.41
First Reported 1981
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.41
Pain Relevance 6.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Emg1)
Anatomy Link Frequency
neurons 1
jaw 1
Emg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 99.50 Very High Very High Very High
Snapping jaw 30 99.46 Very High Very High Very High
Opioid 11 99.14 Very High Very High Very High
Morphine 1 99.06 Very High Very High Very High
narcan 30 98.84 Very High Very High Very High
antagonist 19 98.66 Very High Very High Very High
opiate 16 98.44 Very High Very High Very High
Enkephalin 2 97.96 Very High Very High Very High
electroacupuncture 1 96.64 Very High Very High Very High
Inflammatory response 4 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Recurrence 12 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 30 99.46 Very High Very High Very High
INFLAMMATION 12 95.84 Very High Very High Very High
Pain 2 94.96 High High
Hyperalgesia 1 93.94 High High
Muscle Rigidity 2 84.76 Quite High
Spasticity 6 69.44 Quite High
Muscle Hypertonia 4 68.32 Quite High
Demyelinating Disease 2 50.00 Quite Low
Depression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mustard oil injected into the rat TMJ region evoked significant increases of jaw muscle EMG activity; the vehicle mineral oil had no such effect.
Positive_regulation (increases) of EMG in jaw associated with snapping jaw
1) Confidence 0.41 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807224 Disease Relevance 0.80 Pain Relevance 1.00
The aim of the present study was to test if opioid mechanisms are involved in modulating the EMG increase evoked by mustard oil. 2.
Positive_regulation (increase) of EMG associated with opioid
2) Confidence 0.41 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807224 Disease Relevance 0.75 Pain Relevance 0.93
The increased EMG activity lasted up to 20 min, and by 30 min after the mustard oil injection had returned to control (preinjection) levels, at which time administration of the opiate antagonist naloxone (1.3 mg/kg i.v.) induced a significant recurrence of the increase in EMG activity.
Positive_regulation (increase) of EMG associated with antagonist, narcan, opiate and recurrence
3) Confidence 0.41 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807224 Disease Relevance 0.85 Pain Relevance 1.40
The increased EMG activity lasted up to 20 min, and by 30 min after the mustard oil injection had returned to control (preinjection) levels, at which time administration of the opiate antagonist naloxone (1.3 mg/kg i.v.) induced a significant recurrence of the increase in EMG activity.
Positive_regulation (increased) of EMG associated with antagonist, narcan, opiate and recurrence
4) Confidence 0.41 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807224 Disease Relevance 0.81 Pain Relevance 1.10
Bicuculline given prior to mustard oil augmented the EMG activity evoked by mustard oil, and "rekindling" of EMG activity was induced by bicuculline given 30 min after mustard oil.
Positive_regulation (augmented) of EMG
5) Confidence 0.41 Published 2001 Journal Brain Res. Section Abstract Doc Link 11172764 Disease Relevance 0.17 Pain Relevance 0.39
Bicuculline given prior to mustard oil augmented the EMG activity evoked by mustard oil, and "rekindling" of EMG activity was induced by bicuculline given 30 min after mustard oil.
Positive_regulation (induced) of EMG
6) Confidence 0.41 Published 2001 Journal Brain Res. Section Abstract Doc Link 11172764 Disease Relevance 0.17 Pain Relevance 0.39
Bicuculline given prior to mustard oil augmented the EMG activity evoked by mustard oil, and "rekindling" of EMG activity was induced by bicuculline given 30 min after mustard oil.
Positive_regulation (induced) of EMG
7) Confidence 0.41 Published 2001 Journal Brain Res. Section Abstract Doc Link 11172764 Disease Relevance 0.17 Pain Relevance 0.39
RESULTS: With flupirtine a significant increase in the EMG activity integral was found after 60 min (maximum effect).
Positive_regulation (increase) of EMG
8) Confidence 0.41 Published 1999 Journal Schmerz Section Body Doc Link 12799920 Disease Relevance 0.14 Pain Relevance 0
Placebo did not change the EMG activity integral during the experiment.
Neg (not) Positive_regulation (change) of EMG
9) Confidence 0.41 Published 1999 Journal Schmerz Section Body Doc Link 12799920 Disease Relevance 0.12 Pain Relevance 0
Morphine, a micro-type agonist, in the dose of 40 nmol induced a pronounced EMG activity, while 10 to 40 nmol of [D-Ala2, D-Leu5] enkephalin, a delta-type agonist, led to no or little effect, respectively. beta-Endorphin, which reacts with the epsilon -type of receptors, was completely ineffective in doses of 3 or 15 nmol.
Positive_regulation (induced) of EMG associated with agonist, enkephalin and morphine
10) Confidence 0.20 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6275281 Disease Relevance 0.16 Pain Relevance 0.73
Electrolytic lesion and stimulation of the arcuate nucleus of the hypothalamus (ARH) were investigated in Wistar albino rats. 1) Discrete lesion of the ARH is followed by hyperalgesia as manifested by significantly high values of pain rating in the formalin test and by depressed analgesic effect of electroacupuncture stimulation on digastric electromyogram (dEMG) activity. 2) ARH stimulation appreciably suppressed both the responses of neurons in the lateral hypothalamus (LHA) and dEMG activity induced by tooth pulp stimulation.
Positive_regulation (induced) of dEMG in neurons associated with pain, hyperalgesia, analgesic and electroacupuncture
11) Confidence 0.15 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3219607 Disease Relevance 0.26 Pain Relevance 0.61

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