INT35835

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 10.68
Pain Relevance 9.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) signal transduction (Htr2a) cell death (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
spinal cord 1
cortex 1
helper T cells 1
frontal cortex 1
Htr2a (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 1041 100.00 Very High Very High Very High
antagonist 100 100.00 Very High Very High Very High
analgesia 8 99.92 Very High Very High Very High
Kinase C 77 99.84 Very High Very High Very High
IPN 2 99.84 Very High Very High Very High
Spinal cord 52 99.68 Very High Very High Very High
opioid receptor 1 99.68 Very High Very High Very High
Eae 61 99.56 Very High Very High Very High
Analgesic 38 99.52 Very High Very High Very High
neuralgia 2 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.84 Very High Very High Very High
Endometriosis (extended) 286 99.80 Very High Very High Very High
Stress 28 99.72 Very High Very High Very High
Pain 78 99.40 Very High Very High Very High
Depression 105 99.04 Very High Very High Very High
Urological Neuroanatomy 57 98.44 Very High Very High Very High
Apoptosis 56 98.16 Very High Very High Very High
Sleep Disorders 56 97.60 Very High Very High Very High
Hot Flashes 66 96.96 Very High Very High Very High
Increased Venous Pressure Under Development 99 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, results from the slices where cinanserin reduced the power of the oscillation provide evidence that, in these cases, at least a proportion of the spontaneous oscillations is mediated by activation of 5-HT2 receptors.
Positive_regulation (activation) of 5-HT2
1) Confidence 0.67 Published 2010 Journal Neuroscience Section Body Doc Link PMC2989444 Disease Relevance 0.20 Pain Relevance 0.03
These results show the utility of the PAM model in studying nonopiate analgesia and suggest that the analgesic action of serotonin is mediated primarily through the 5HT2 receptor.
Positive_regulation (mediated) of 5HT2 receptor associated with analgesic, serotonin and analgesia
2) Confidence 0.50 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3224281 Disease Relevance 0 Pain Relevance 1.23
The 5HT2A/2C receptor antagonist, ritanserin (0.5 mg/kg), was not active in the TST when given by itself, and it did not influence the LY341495-induced attenuation of the immobility time in the TST in mice [F(1,27)?
Neg (not) Positive_regulation (active) of 5HT2A associated with antagonist
3) Confidence 0.45 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.45
The 5-HT2AR in the brain cortex has been reported to be up-regulated during chronic stress due to maternal deprivation.35
Positive_regulation (up-regulated) of 5-HT2AR in cortex associated with stress
4) Confidence 0.45 Published 2008 Journal Journal of the European Academy of Dermatology and Venereology Section Body Doc Link PMC2229631 Disease Relevance 0.37 Pain Relevance 0.16
Acute noise stress analgesia in relation to 5-HT2 and mu-opioid receptor changes in the frontal cortex of young mice.
Positive_regulation (relation) of 5-HT2 in frontal cortex associated with stress, urological neuroanatomy, opioid receptor and analgesia
5) Confidence 0.40 Published 2005 Journal Life Sci. Section Title Doc Link 15935399 Disease Relevance 1.01 Pain Relevance 0.39
[Involvement of peripheral 5-HT2A receptor activation in inflammatory pain].
Positive_regulation (activation) of 5-HT2A receptor associated with neuralgia and ipn
6) Confidence 0.13 Published 2001 Journal Nippon Rinsho Section Title Doc Link 11554035 Disease Relevance 0.79 Pain Relevance 1.04
E2's upregulation of 5HT2A in the spinal cord could be a factor in the development of fibromyalgia, which presents as increased generalized pain sensation.
Positive_regulation (upregulation) of 5HT2A in spinal cord associated with pain, fibrositis and spinal cord
7) Confidence 0.04 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.25 Pain Relevance 1.52
As described above, the higher E2 concentrations in the presence of progesterone prior to menopause cause an increase in 5HT2A receptor density and serotonin activity that promotes apoptosis.
Positive_regulation (increase) of 5HT2A receptor associated with endometriosis (extended), apoptosis and serotonin
8) Confidence 0.04 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.71 Pain Relevance 0.13
-produced upregulation of 5HT2A receptors.
Positive_regulation (upregulation) of 5HT2A
9) Confidence 0.03 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.08 Pain Relevance 0.52
After E2 exposure, increased serotonin concentrations result in greater activation of both the 5HT1B and 5HT2A receptors.
Positive_regulation (activation) of 5HT2A associated with serotonin
10) Confidence 0.03 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.11 Pain Relevance 0.97
The increased levels of serotonin and increased activity of the 5HT2A receptor caused by E2 could be the mechanism for E2's antidepressant effects, in which case 5HT2A receptor agonists could also enhance the anti-depressant effects of E2.


Positive_regulation (increased) of 5HT2A receptor associated with antidepressant, agonist and serotonin
11) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.73 Pain Relevance 0.76
activation results in upregulation of the 5HT2A receptor,[25] while ER?
Positive_regulation (upregulation) of 5HT2A receptor
12) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.05 Pain Relevance 0.51
Increased E2 in the presence of progesterone increases activation of 5HT2A receptors, while increased E2 in the absence of progesterone increases activation of 5HT1A receptors.
Positive_regulation (activation) of 5HT2A
13) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.12 Pain Relevance 0.11
The increased levels of serotonin and increased activity of the 5HT2A receptor caused by E2 could be the mechanism for E2's antidepressant effects, in which case 5HT2A receptor agonists could also enhance the anti-depressant effects of E2.


Positive_regulation (increased) of 5HT2A receptor associated with antidepressant, agonist and serotonin
14) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.75 Pain Relevance 0.77
With reduced levels of E2, 5HT1A receptors are disinhibited and counter the effects of 5HT2A receptor activation.
Positive_regulation (activation) of 5HT2A receptor
15) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.50
Specifically, increased 5HT2A activity causes decreased MHC II production,[107] and decreased selection against self-reactive helper T cells (TH1) [108].
Positive_regulation (increased) of 5HT2A in helper T cells
16) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.51 Pain Relevance 0.16
Following 5HT2A activation of PKC, 5HT1A receptors become unable to reduce serotonin production through negative feedback, and serotonin concentrations increase [32-34] E2 compounds this effect by directly inhibiting 5HT1A function [35,36].
Positive_regulation (activation) of 5HT2A associated with kinase c and serotonin
17) Confidence 0.02 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.57

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