INT35862

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Context Info
Confidence 0.00
First Reported 1988
Last Reported 1988
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GBE1) transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
cytosol (GBE1) extracellular space (PRSS1) peptidase activity (PRSS1)
Anatomy Link Frequency
plasma 2
PRSS1 (Homo sapiens)
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 8 99.40 Very High Very High Very High
Bile 2 99.28 Very High Very High Very High
Chronic pancreatitis 2 94.28 High High
Disease Link Frequency Relevance Heat
Pancreatitis 2 94.28 High High
Exocrine Pancreatic Insufficiency 2 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study does not support the hypothesis of a trypsin-mediated negative feedback control of human pancreatic enzyme secretion.
trypsin Regulation (control) of Localization (secretion) of enzyme
1) Confidence 0.00 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.17 Pain Relevance 0.29
The concentrations of secretin and CCK in plasma and the pancreatic enzyme and volume secretions were unaffected by the addition of trypsin, but the initial bile acid output and the bicarbonate secretion in the period after gallbladder emptying were reduced during perfusion with trypsin.
trypsin Neg (unaffected) Regulation (unaffected) of Localization (secretions) of enzyme in plasma associated with bile and cholecystokinin
2) Confidence 0.00 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.18 Pain Relevance 0.30

General Comments

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