INT35872

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Context Info
Confidence 0.56
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.38
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 6
aorta 2
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 8 99.56 Very High Very High Very High
ischemia 7 98.80 Very High Very High Very High
bradykinin 3 91.16 High High
Restless leg syndrome 1 75.00 Quite High
antagonist 1 71.20 Quite High
Paracetamol 5 50.00 Quite Low
Angina 1 47.00 Quite Low
anesthesia 2 25.00 Low Low
agonist 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 6 99.56 Very High Very High Very High
Coronary Artery Disease 6 99.24 Very High Very High Very High
Cv Unclassified Under Development 2 98.76 Very High Very High Very High
Hypertension 2 98.36 Very High Very High Very High
Diabetes Mellitus 1 97.80 Very High Very High Very High
Atherosclerosis 1 97.40 Very High Very High Very High
Disease 2 86.40 High High
Increased Venous Pressure Under Development 11 75.00 Quite High
Hypoxia 1 69.12 Quite High
Hypersensitivity 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SQ 80,338 (10.0 micrograms/ml) prevented arachidonate-induced release of TXA2 from the isolated perfused guinea pig lung while SQ 24,775 (1.0 microgram/ml) antagonized the contraction of the isolated rat aorta induced by 9,11,AZO-PGH2.
Negative_regulation (prevented) of Localization (release) of TXA2 in aorta
1) Confidence 0.56 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6807699 Disease Relevance 0 Pain Relevance 0.12
The clinical improvement was not associated with an increase in the ankle pressure index or a reduction in platelet aggregation and thromboxane A2 release.
Negative_regulation (reduction) of Localization (release) of thromboxane A2 in platelet
2) Confidence 0.55 Published 1988 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 3229875 Disease Relevance 0.15 Pain Relevance 0.07
Since NO suppresses platelet aggregation as well as vascular release of TXA2, NO-deficiency is often associated with activation of TP-receptors.
Negative_regulation (suppresses) of Localization (release) of TXA2 in platelet
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.75 Pain Relevance 0.13
Release of thromboxane B2 was also dose-dependently inhibited by acetaminophen.
Negative_regulation (inhibited) of Localization (Release) of thromboxane B2
4) Confidence 0.07 Published 2005 Journal Anesthesiology Section Body Doc Link 16192763 Disease Relevance 0 Pain Relevance 0
These findings suggest that ibuprofen stabilizes membranes and prevents platelet-activated release of thromboxane A2 in pacing-induced myocardial ischemia.
Negative_regulation (prevents) of Localization (release) of thromboxane A2 in platelet associated with coronary artery disease and ischemia
5) Confidence 0.04 Published 1983 Journal Am. J. Cardiol. Section Abstract Doc Link 6829434 Disease Relevance 0.48 Pain Relevance 0.20

General Comments

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