INT35885

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.10
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP3) nucleolus (DPP3) plasma membrane (DPP3)
nucleus (DPP3) cytoplasm (DPP3)
Anatomy Link Frequency
cerebrospinal fluid 1
DPP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 10 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
Spinal cord 1 66.84 Quite High
Disease Link Frequency Relevance Heat
Pain 2 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Activity of DPP III in human cerebrospinal fluid derived from patients with pain].
Positive_regulation ([Activity) of DPP III in cerebrospinal fluid associated with pain
1) Confidence 0.50 Published 2003 Journal Masui Section Title Doc Link 12703067 Disease Relevance 0.10 Pain Relevance 0.38
Co2 prevented DPP III inactivation by di(4-pyridyl)disulfide, indicating that it is a metallo-peptidase with essential SH-groups which might be near or at the binding site for the metal.
Positive_regulation (inactivation) of DPP III
2) Confidence 0.49 Published 1988 Journal Biol. Chem. Hoppe-Seyler Section Abstract Doc Link 3348886 Disease Relevance 0 Pain Relevance 0.06
The inhibitory activity of tynorphin toward other enkephalin-degrading enzymes such as neutral endopeptidase, aminopeptidase, and angiotensin-converting enzyme was not as high as that toward DPPIII, suggesting that tynorphin is a specific inhibitor of DPPIII.
Neg (not) Positive_regulation (high) of DPPIII associated with enkephalin
3) Confidence 0.42 Published 2000 Journal Peptides Section Abstract Doc Link 10822105 Disease Relevance 0 Pain Relevance 0.20
Human placental dipeptidyl aminopeptidase III: hydrolysis of enkephalins and its stimulation by cobaltous ion.
Positive_regulation (stimulation) of aminopeptidase III associated with enkephalin
4) Confidence 0.26 Published 1988 Journal Biochem. Med. Metab. Biol. Section Title Doc Link 3233187 Disease Relevance 0 Pain Relevance 0.55

General Comments

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