INT3589

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 101
Total Number 112
Disease Relevance 46.01
Pain Relevance 21.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
chest 5
oocyte 3
SSS 2
inferior 2
sperm 2
SCN5A (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 304 100.00 Very High Very High Very High
tetrodotoxin 65 100.00 Very High Very High Very High
Migraine 23 99.92 Very High Very High Very High
Angina 45 99.68 Very High Very High Very High
chest pain 5 99.44 Very High Very High Very High
Dopamine 13 99.40 Very High Very High Very High
Central grey 27 99.36 Very High Very High Very High
sodium channel 24 99.32 Very High Very High Very High
headache 40 99.24 Very High Very High Very High
endometriosis 194 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 418 100.00 Very High Very High Very High
Subclavian Steal Syndrome 5 100.00 Very High Very High Very High
Headache 55 99.92 Very High Very High Very High
Bundle-branch Block 1 99.90 Very High Very High Very High
Congenital Anomalies 59 99.84 Very High Very High Very High
Emergencies 18 99.84 Very High Very High Very High
Diabetes Mellitus 376 99.82 Very High Very High Very High
Apoptosis 53 99.72 Very High Very High Very High
Angina 36 99.68 Very High Very High Very High
Endometriosis 28 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, unresolved grief was the main experience of remaining childless after undergoing unsuccessful IVF.
Positive_regulation (undergoing) of IVF
1) Confidence 0.57 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.15 Pain Relevance 0
One male reflection was that not everyone undergoing IVF was mentally strong enough to deal with failure after failure.
Neg (not) Positive_regulation (undergoing) of IVF
2) Confidence 0.57 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.17 Pain Relevance 0
First, an invitation letter including a written consent to participate was sent to women (n = 49) who had undergone IVF and had no further IVF treatments at the public clinic after a minimum of 3 years.
Positive_regulation (undergone) of IVF
3) Confidence 0.57 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0 Pain Relevance 0
subunits are inhibited by TTX in the micromolar range and include SCN5A (also known as Nav1.5), SCN10A (also known as Nav1.8), and SCN11A (also known as Nav1.9) [2,5].
Positive_regulation (include) of SCN5A associated with tetrodotoxin, nav1.8 and nav1.9
4) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.30
The data indicate that SCN5A is more widely distributed than previously thought and encodes the pore-forming alpha-subunit of the tetrodotoxin-resistant Na+ current in HJCSM cells.
Positive_regulation (distributed) of SCN5A in pore associated with tetrodotoxin
5) Confidence 0.47 Published 2002 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12358675 Disease Relevance 0 Pain Relevance 0.15
The aim of this study was to screen SCN5A for mutations in a family with the LQT3 phenotype and to analyze the consequences of the mutation on the channel function.
Positive_regulation (screen) of SCN5A
6) Confidence 0.47 Published 2003 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 14654377 Disease Relevance 0.25 Pain Relevance 0.12
LQT variant 3 (LQT-3) is caused by mutations in SCN5A, the gene coding for the alpha subunit (NaV1.5) of the primary cardiac voltage-gated Na+ channel in the human heart.
Positive_regulation (caused) of LQT-3 in heart
7) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.47 Pain Relevance 0.04
The electrocardiogram showed ST-segment elevation in the leads II, III, and aVF, consistent with inferior wall AMI.
Positive_regulation (elevation) of aVF in inferior associated with myocardial infarction
8) Confidence 0.45 Published 2009 Journal Turk Kardiyol Dern Ars Section Abstract Doc Link 20098047 Disease Relevance 1.29 Pain Relevance 0.54
These findings strongly suggest that activation of tetrodotoxin sensitive Na+ channel may play a primary role at twitch generation during exposure of the frog rectus abdominis to Ca(2+)-free Ringer solution with Na2 EDTA.
Positive_regulation (activation) of tetrodotoxin in rectus abdominis associated with tetrodotoxin
9) Confidence 0.44 Published 1997 Journal Acta Med. Okayama Section Abstract Doc Link 9227789 Disease Relevance 0 Pain Relevance 0.34
This review aims to evaluate whether severe endometriosis has an impact on the outcome of in vitro fertilisation (IVF), whether IVF is associated with specific complications in this context, whether a specific ovarian stimulation protocol is most appropriate, whether the endometrial condition progresses following ovarian stimulation, and whether endometrial cysts pose a specific problem for IVF.
Spec (whether) Positive_regulation (fertilisation) of IVF associated with endometriosis and cyst
10) Confidence 0.42 Published 2009 Journal Gynecol. Endocrinol. Section Abstract Doc Link 19908950 Disease Relevance 0.47 Pain Relevance 0.15
Functional analysis of the mutation, introduced in the highly homologous human SCN5A, revealed markedly slowed inactivation and a two-fold faster recovery from fast inactivation predicting enhanced neuronal excitation.
Positive_regulation (introduced) of SCN5A in neuronal
11) Confidence 0.42 Published 2007 Journal Hum. Mutat. Section Abstract Doc Link 17397047 Disease Relevance 0.88 Pain Relevance 0.69
Grief is one of the main experiences of being childless in women 2 years after ending unsuccessful IVF (13).
Positive_regulation (unsuccessful) of IVF
12) Confidence 0.41 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.22 Pain Relevance 0.08
A lack of professional support and how men took the supportive role after treatment failure were also described and indicated that men were in need of their own individual support and were in need of their own individual support while undergoing IVF treatment.
Positive_regulation (undergoing) of IVF
13) Confidence 0.41 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.44 Pain Relevance 0.07
Unanswered questions after ending IVF
Positive_regulation (ending) of IVF
14) Confidence 0.41 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.18 Pain Relevance 0
Because the procedure is simple and inexpensive, we believe that it may replace laparoscopy as a method for oocyte collection in most patients who undergo IVF.
Positive_regulation (undergo) of IVF in oocyte
15) Confidence 0.41 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2942426 Disease Relevance 0.07 Pain Relevance 0.21
These data indicated that SSS caused by congenital malformation was not so rare as previously believed.
Positive_regulation (caused) of SSS associated with congenital anomalies and subclavian steal syndrome
16) Confidence 0.40 Published 1988 Journal Jpn. Circ. J. Section Abstract Doc Link 3062202 Disease Relevance 0.96 Pain Relevance 0.13
A 31-year-old female with four years of infertility due to endometriosis and severe pelvic adhesions underwent transvaginal ultrasound-guided aspiration of an ovarian endometrioma before ovulation induction for in vitro fertilization (IVF) and embryo transfer.
Positive_regulation (induction) of IVF in embryo associated with endometriosis, reprotox - general 3 and adhesions
17) Confidence 0.39 Published 1998 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 9830238 Disease Relevance 0.72 Pain Relevance 0.14
Although the study was not of adequate size to test for the significance of between group differences in rates of disorders affecting the central nervous system, the authors reported that seizures and cerebral palsy occurred at double the rate in IVF than SC singletons and that this rate was even higher for the IVF twins.
Positive_regulation (higher) of IVF in central nervous system associated with convulsion, cerebral palsy and central nervous system
18) Confidence 0.39 Published 2008 Journal Reprod Health Section Body Doc Link PMC2583986 Disease Relevance 0.88 Pain Relevance 0.05
The electrocardiogram (ECG) during the chest pain attack revealed ST elevation in leads II, III and aVF.
Positive_regulation (elevation) of aVF in chest associated with angina
19) Confidence 0.39 Published 1990 Journal Jpn Heart J Section Abstract Doc Link 2159572 Disease Relevance 0.68 Pain Relevance 0.29
Previous qualitative studies exploring the experience of childlessness after undergoing unsuccessful IVF have focused on women (13–15) or interviews have been conducted with the couple together, not individually (16,17).
Positive_regulation (undergoing) of IVF
20) Confidence 0.38 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.16 Pain Relevance 0.08

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