INT35895

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.25
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sord) oxidoreductase activity (Sord) cilium (Sord)
Anatomy Link Frequency
plasma 5
blood 1
liver 1
Sord (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 61 99.82 Very High Very High Very High
alcohol 5 98.28 Very High Very High Very High
addiction 1 85.72 High High
Bile 1 73.12 Quite High
Analgesic 1 70.72 Quite High
Disease Link Frequency Relevance Heat
Injury 4 99.92 Very High Very High Very High
Necrosis 11 99.88 Very High Very High Very High
Hepatotoxicity 17 99.64 Very High Very High Very High
Nephrotoxicity 9 97.88 Very High Very High Very High
Toxicity 6 89.88 High High
Death 1 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experimentally induced hepatotoxicity in the mouse by acetaminophen produced a dose dependent increase in blood sorbitol dehydrogenase activity.
Positive_regulation (increase) of sorbitol dehydrogenase in blood associated with paracetamol and hepatotoxicity
1) Confidence 0.69 Published 1988 Journal J. Clin. Chem. Clin. Biochem. Section Abstract Doc Link 3235951 Disease Relevance 0.17 Pain Relevance 0.10
Plasma sorbitol dehydrogenase activity was elevated after 600 mg/kg but not after 300 mg/kg.
Neg (not) Positive_regulation (elevated) of Plasma sorbitol dehydrogenase in Plasma
2) Confidence 0.61 Published 1987 Journal Toxicol Pathol Section Abstract Doc Link 3432943 Disease Relevance 0.57 Pain Relevance 0.25
None of the pretreatments altered the APAP-induced elevation of plasma sorbitol dehydrogenase activity, nor were there any detectable changes in liver histopathology after APAP challenge.
Positive_regulation (elevation) of sorbitol dehydrogenase in liver associated with paracetamol
3) Confidence 0.45 Published 1996 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8560470 Disease Relevance 0.33 Pain Relevance 1.04
At 24 h after APAP, hepatotoxicity was evident in control mice by elevated plasma sorbitol dehydrogenase activity (SDH) and histologic evidence of hepatic degeneration and necrosis.
Positive_regulation (elevated) of sorbitol dehydrogenase in plasma associated with necrosis, paracetamol and hepatotoxicity
4) Confidence 0.37 Published 1999 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 10522648 Disease Relevance 0.52 Pain Relevance 0.72
Elevated plasma sorbitol dehydrogenase activity and centrilobular hepatocellular necrosis was present in control mice receiving APAP at 12 and 24 h.
Positive_regulation (Elevated) of plasma sorbitol dehydrogenase in plasma associated with necrosis
5) Confidence 0.26 Published 2001 Journal Food Chem. Toxicol. Section Abstract Doc Link 11278059 Disease Relevance 0.44 Pain Relevance 0.18
YGW dramatically abolished the elevated activities of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) and reduced the necrosis induced by AlOH.
Positive_regulation (elevated) of sorbitol dehydrogenase associated with necrosis and alcohol
6) Confidence 0.25 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10999434 Disease Relevance 0.26 Pain Relevance 0.68
All groups exhibited hepatotoxicity after APAP with similar glutathione (GSH) depletion, covalent binding, centrilobular necrosis, and elevation of plasma sorbitol dehydrogenase activity.
Positive_regulation (elevation) of sorbitol dehydrogenase in plasma associated with necrosis, paracetamol and hepatotoxicity
7) Confidence 0.24 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.70 Pain Relevance 0.85
At 12 hr, hepatotoxicity was evidenced by elevated plasma sorbitol dehydrogenase and histopathology in corn oil but not in CFB-pretreated mice.
Positive_regulation (elevated) of plasma sorbitol dehydrogenase in plasma associated with hepatotoxicity
8) Confidence 0.21 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7992315 Disease Relevance 0.26 Pain Relevance 0.64

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