INT35896

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.33
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mrc1) signal transduction (Mrc1) plasma membrane (Mrc1)
Anatomy Link Frequency
muscle 1
Mrc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 7 93.44 High High
Central nervous system 14 89.24 High High
antagonist 2 84.36 Quite High
Opioid 3 83.92 Quite High
Inflammation 19 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 9 99.66 Very High Very High Very High
Cancer 179 99.16 Very High Very High Very High
Toxicity 11 88.56 High High
Colorectal Cancer 26 84.52 Quite High
Death 10 76.80 Quite High
Malignant Neoplastic Disease 7 72.32 Quite High
Lung Cancer 10 63.28 Quite High
Microsatellite Instability 15 58.00 Quite High
Chromosomal Instability 1 27.28 Quite Low
Endometrial Cancer 14 14.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although smaller doses (1.0, 3.0 and 10.0 mg/kg) of Mr2266 failed to affect significantly the intake of water, a larger dose (30.0 mg/kg) elicited a significant attenuation in the intake of water.
Neg (failed) Regulation (affect) of Mr2266
1) Confidence 0.44 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3237313 Disease Relevance 0 Pain Relevance 0.29
How do targets of the MMR mutator phenotype influence tumor specificity?
Regulation (targets) of MMR mutator associated with cancer
2) Confidence 0.31 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.60 Pain Relevance 0
In contrast to RMS, MR would not be affected by peripheral muscle fibre properties.
Neg (not) Regulation (affected) of MR in muscle
3) Confidence 0.27 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1557523 Disease Relevance 0 Pain Relevance 0.20
Salnikow and Zhitkovich (2008) have also posited that Cr(VI)-induced carcinogenesis might involve genomic instability arising through effects on MMR genes (Salnikow and Zhitkovich, 2008).
Regulation (effects) of MMR associated with genomic instability
4) Confidence 0.03 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.73 Pain Relevance 0

General Comments

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