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Context Info
Confidence 0.39
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Sgpl1) endoplasmic reticulum (Sgpl1) lipid metabolic process (Sgpl1)
Anatomy Link Frequency
blood 1
Sgpl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 92.80 High High
Bile 1 84.96 Quite High
Inflammatory response 4 71.00 Quite High
depression 1 60.48 Quite High
Central nervous system 1 22.76 Low Low
Spinal cord 1 20.84 Low Low
Inflammation 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 31 95.92 Very High Very High Very High
Stress 6 93.48 High High
Pain 2 92.80 High High
Disorder Of Lipid Metabolism 1 88.36 High High
Parkinson's Disease 1 84.00 Quite High
Optic Nerve Injuries 34 81.48 Quite High
Metabolic Disorder 1 75.00 Quite High
Hypoxia 1 74.72 Quite High
INFLAMMATION 7 70.64 Quite High
Shock 1 67.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lipid peroxidation was activated in liver tissue of the animals, which was expressed as an increase in the MDA content, a decrease in SOD activity and as marked activation of fructose I-phosphate aldolase, an enzyme specific for liver tissue, in blood serum.
Positive_regulation (activation) of I-phosphate aldolase in blood
1) Confidence 0.39 Published 1988 Journal Vopr. Med. Khim. Section Abstract Doc Link 3238931 Disease Relevance 0.69 Pain Relevance 0.24
Our array study reveals that the RNA of some enzymes linked to sphingosine metabolism are soon upregulated after IONT (Sphk1 and Sgpl1) and after IONC (Sphk1 and 2) [58-60].
Positive_regulation (upregulated) of Sgpl1
2) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.18 Pain Relevance 0.06

General Comments

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