INT35910

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Context Info
Confidence 0.37
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 4.79
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
plasma 3
brain 2
lungs 2
B cell 1
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 11 100.00 Very High Very High Very High
antidepressant 4 100.00 Very High Very High Very High
Endogenous opioid 2 99.76 Very High Very High Very High
Opioid 3 99.38 Very High Very High Very High
Enkephalin 17 99.02 Very High Very High Very High
narcan 12 98.84 Very High Very High Very High
opiate 1 98.08 Very High Very High Very High
antagonist 1 97.44 Very High Very High Very High
Inflammation 37 96.32 Very High Very High Very High
Analgesic 9 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 440 99.44 Very High Very High Very High
Follicular Lymphoma 25 99.44 Very High Very High Very High
Mantle-cell Lymphoma 17 97.76 Very High Very High Very High
INFLAMMATION 44 96.32 Very High Very High Very High
Genetic Translocation 1 95.24 Very High Very High Very High
Hyperplasia 2 94.76 High High
Splenomegaly 4 93.52 High High
Cancer 13 93.12 High High
Lymphatic System Cancer 84 87.92 High High
Sepsis 10 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the properties of BL-2401 ((+/-)-3-[2-benzyl-3-(propionylthio) propionyl]amino-5-methylbenzoic acid), a novel enkephalinase inhibitor, we examined its antinociceptive and antidepressant-like activities after oral administration, along with their association with endogenous opioid systems.
enkephalinase Binding (association) of associated with antidepressant, endogenous opioid and antinociceptive
1) Confidence 0.37 Published 1997 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9469639 Disease Relevance 0.15 Pain Relevance 0.63
Differential recognition of "enkephalinase" and angiotensin-converting enzyme by new carboxyalkyl inhibitors.
enkephalinase Binding (recognition) of
2) Confidence 0.35 Published 1982 Journal Life Sci. Section Title Doc Link 6298535 Disease Relevance 0 Pain Relevance 0.17
Differential recognition of both brain enkephalinase and angiotensin-converting enzyme (ACE) catalytic sites by these carboxylalkyl compounds lead to potent (KI approximately 0.5 microM), competitive and selective inhibitors of the enkephalin-degrading enzyme.
brain enkephalinase Binding (recognition) of in brain associated with enkephalin
3) Confidence 0.35 Published 1983 Journal J. Med. Chem. Section Abstract Doc Link 6298420 Disease Relevance 0 Pain Relevance 0.42
Decreased plasma NEP activity in mice with acute lung injury
NEP Binding (activity) of in plasma associated with adult respiratory distress syndrome
4) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.27 Pain Relevance 0.05
For measurements of NEP activity in mouse lungs, each specimen was homogenized with 5 volumes of 50 mM homogenate HEPES buffer at pH 7.4, containing 1 mM ethylene glycol tetraacetic acid, 50 ?
NEP Binding (activity) of in lungs
5) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0 Pain Relevance 0
Decreased lung NEP activity in mice with acute lung injury
NEP Binding (activity) of in lung associated with adult respiratory distress syndrome
6) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.30 Pain Relevance 0.03
NEP activity in plasma of patients with ALI/ARDS
NEP Binding (activity) of in plasma associated with adult respiratory distress syndrome
7) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.52 Pain Relevance 0
Carbapethiol alone and, even more, when associated with an enkephalinase inhibitor, exerted a potent naloxone-reversible antinociceptive activity.
enkephalinase Binding (associated) of associated with narcan and antinociceptive
8) Confidence 0.32 Published 1988 Journal Neuropeptides Section Abstract Doc Link 3241626 Disease Relevance 0 Pain Relevance 0.40
These data indicate that the tripeptide is in a dynamic state in the brain and that its levels might reflect the release of endogenous enkephalins or related opioid peptides and their subsequent metabolism by enkephalinase.
enkephalinase Spec (might) Binding (metabolism) of in brain associated with enkephalin and opioid
9) Confidence 0.32 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3912194 Disease Relevance 0 Pain Relevance 0.47
The measurements made with this sensitive method indicated that the activity of NEP in plasma was decreased during ALI.
NEP Binding (activity) of in plasma associated with adult respiratory distress syndrome
10) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.13 Pain Relevance 0.03
The antinociceptive effects of Thiorphan, an 'enkephalinase' inhibitor, or bestatin, an aminopeptidase inhibitor, as well as of their association and the pronociceptive effects of naloxone, an opiate receptor antagonist, were evaluated in various analgesic tests in mice.
enkephalinase Binding (association) of associated with analgesic, antagonist, narcan, opiate and antinociceptive
11) Confidence 0.21 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3519246 Disease Relevance 0.07 Pain Relevance 0.76
The antigen profile includes CD20, CD19 and CD5 positive, and is BCL-2 and cyclin D1 positive but usually CD10 and BCL-6 negative.
CD10 Binding (negative) of
12) Confidence 0.08 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.33 Pain Relevance 0
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, HLA-DR and kappa, but negative for CD5, CD10, CD23, and CD34, and tdT.
CD10 Binding (negative) of in B cell
13) Confidence 0.03 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.02 Pain Relevance 0.19

General Comments

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