INT35926

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.34
Pain Relevance 0.66

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signal transduction (NMU) extracellular region (NMU) response to stress (NMU)
Anatomy Link Frequency
NMU 2
smooth muscle 1
BHK 1
NMU (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 13 100.00 Very High Very High Very High
Pain 2 91.80 High High
tetrodotoxin 1 78.88 Quite High
headache 2 75.68 Quite High
antagonist 1 65.64 Quite High
agonist 4 65.04 Quite High
Glutamate receptor 3 50.32 Quite High
chemokine 7 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arachnoid Cysts 51 98.20 Very High Very High Very High
Anxiety Disorder 2 93.84 High High
Pain 2 91.80 High High
Chromosome Duplication 1 90.60 High High
Cyst 11 84.60 Quite High
Dizziness 2 76.12 Quite High
Headache 2 75.68 Quite High
Campomelic Dysplasia 4 5.00 Very Low Very Low Very Low
Meningioma 3 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report the overexpression of the human NmU(2)R in the methylotrophic yeast Pichia pastoris and baby hamster kidney (BHK) cells using the Semliki Forest virus (SFV) system.
Gene_expression (overexpression) of NmU in BHK
1) Confidence 0.75 Published 2007 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 17445746 Disease Relevance 0.17 Pain Relevance 0.13
The gut neuropeptide, neuromedin U octapeptide (NMU-8) produced transient elevations in short-circuit current (EC50 = 0.7 nmol/l) after its contraluminal administration to sheets of porcine distal jejunal mucosa in vitro.
Gene_expression (produced) of neuromedin U in NMU associated with neuropeptide
2) Confidence 0.65 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3243329 Disease Relevance 0 Pain Relevance 0.13
Neuromedin U, a potent neuropeptide that causes contraction of smooth muscle, was correctly predicted phylogenetically to be the ligand of the orphan GPCR FM3 (NMUR) [15].
Gene_expression (predicted) of Neuromedin U in smooth muscle associated with neuropeptide
3) Confidence 0.65 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.14
Heterologous expression and comparative characterization of the human neuromedin U subtype II receptor using the methylotrophic yeast Pichia pastoris and mammalian cells.
Gene_expression (expression) of neuromedin U associated with neuropeptide
4) Confidence 0.58 Published 2007 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 17445746 Disease Relevance 0.19 Pain Relevance 0.19
Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples.
Gene_expression (expression) of NMU in NMU associated with arachnoid cysts
5) Confidence 0.13 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2841093 Disease Relevance 0.99 Pain Relevance 0.08

General Comments

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