INT3593

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Context Info
Confidence 0.75
First Reported 1975
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 70
Total Number 74
Disease Relevance 29.48
Pain Relevance 20.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
blood cells 4
oocytes 3
plasma 2
sympathetic 2
erythrocyte 2
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 78 100.00 Very High Very High Very High
rapifen 28 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Spinal cord 8 99.98 Very High Very High Very High
agonist 33 99.92 Very High Very High Very High
Cannabinoid 10 99.74 Very High Very High Very High
Cluster headache 6 99.70 Very High Very High Very High
Opioid 14 99.60 Very High Very High Very High
noradrenaline 24 99.34 Very High Very High Very High
Inflammation 13 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 22 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 8 100.00 Very High Very High Very High
Neuroblastoma 6 100.00 Very High Very High Very High
Cancer 93 99.86 Very High Very High Very High
Pancreatic Cancer 114 99.84 Very High Very High Very High
Cluster Headache 6 99.70 Very High Very High Very High
Urinary Calculi 6 99.52 Very High Very High Very High
Inflammatory Bowel Disease 20 99.42 Very High Very High Very High
Overactive Bladder 52 99.40 Very High Very High Very High
Malignant Neoplastic Disease 10 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis showed that the tumor cells expressed AFP, alpha 1-antitrypsin (AT) and albumin.
Gene_expression (expressed) of alpha 1 associated with cancer
1) Confidence 0.75 Published 1999 Journal Int. J. Pancreatol. Section Abstract Doc Link 10566157 Disease Relevance 0.71 Pain Relevance 0.08
METHODS: Heteromeric human neuronal nicotinic acetylcholine receptors (hnAChR channels alpha2beta2, alpha2beta4, alpha3beta2, alpha3beta4, alpha4beta2 and alpha4beta4), 5-hydroxytryptamine3 (5-HT3), alpha1beta2gamma2S gamma-aminobutyric acid type A (GABAA) and alpha1 glycine receptors were expressed in Xenopus oocytes, and effects of ketamine and dizocilpine were studied using the two-electrode voltage-clamp technique.
Gene_expression (expressed) of alpha1 in oocytes
2) Confidence 0.75 Published 2000 Journal Anesthesiology Section Body Doc Link 10754635 Disease Relevance 0 Pain Relevance 0
Cotransfection of TR alpha 1 along with ER alpha inhibited the ER alpha transactivation of PPE by approximately 50%.
Gene_expression (Cotransfection) of alpha 1
3) Confidence 0.75 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0.08 Pain Relevance 0
Alterations of methadone protein binding caused by an inhibition of alpha1-acid glycoprotein synthesis by alkylating substances are another possibility for predominantly pharmacokinetically based drug interactions during PCA.
Gene_expression (synthesis) of alpha1 associated with patient controlled alalgesia and methadone
4) Confidence 0.75 Published 2002 Journal Clin Pharmacokinet Section Abstract Doc Link 11825096 Disease Relevance 0.22 Pain Relevance 1.70
The levels of expression of Na+, K+-ATPase alpha1- and beta1-isoform proteins were also lower in UC patients than in controls, although there were no differences in Na+, K+-ATPase alpha1- and beta1-isoform mRNA levels between the two groups.
Gene_expression (expression) of alpha1 associated with inflammatory bowel disease
5) Confidence 0.75 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.82 Pain Relevance 0.08
The present study characterised the effects of cannabinoid agonists on alpha1, alpha1beta, alpha2 and alpha3 GlyRs recombinantly expressed in HEK293 cells with the aims of reconciling effects of cannabinoids on these receptor subtypes and to establish the potential of different GlyR isoforms as novel physiological or analgesic targets for cannabinoids.
Gene_expression (expressed) of alpha1 associated with analgesic, cannabinoid and agonist
6) Confidence 0.75 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0.09 Pain Relevance 0.64
In the melanocyte this signalling is redundant due to the high expression of alpha1 and beta2-adrenoceptors.
Gene_expression (expression) of alpha1 in melanocyte
7) Confidence 0.75 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.09
The effective mechanism of phenylephrine might involve the increased expression of alpha1-AR, translocation of AQP(5) from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland.
Gene_expression (expression) of alpha1 in gland associated with frailty
8) Confidence 0.75 Published 2007 Journal Beijing Da Xue Xue Bao Section Abstract Doc Link 17304317 Disease Relevance 0.09 Pain Relevance 0.08
METHODS: alpha1beta2gamma2sgamma-aminobutyric acid type A (GABA(A)), alpha1 glycine, NR1/NR2A N-methyl-d-aspartate, and two pore domain TRESK channels were expressed in Xenopus laevis oocytes and studied using two-electrode voltage clamping.
Gene_expression (expressed) of alpha1 in oocytes
9) Confidence 0.75 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17717222 Disease Relevance 0 Pain Relevance 0
We have thus concluded that bile duct ligation induces a defect in the functional expression of cardiovascular alpha 1-adrenoceptors without any effects on the activity of alpha 2-adrenoceptors or norepinephrine uptake.
Gene_expression (expression) of alpha 1 in bile duct associated with bile
10) Confidence 0.75 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8105696 Disease Relevance 0.07 Pain Relevance 0.50
Compared to the pre-CPB period as well as to patients not exposed to CPB, CABG patients after CPB exhibited an increased elimination half-time (t1/2 beta = 180 +/- 55 min SD), central distribution volume (Vc = 0.25 +/- 0.07 L/kg), and total volume of distribution (Vdss 0.63 +/- 0.08 L/kg; Vd area 0.92 +/- 0.23 L/kg) which reflected a 33%-50% decrease in alpha 1-acid glycoprotein, the principal plasma protein to which alfentanil is bound.
Gene_expression (bound) of alpha 1 in plasma associated with rapifen
11) Confidence 0.65 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 8311274 Disease Relevance 0 Pain Relevance 0.49
Our findings indicate that alpha 1-adrenoceptors are present in the epidermis, and suggest that their numbers may be increased in the hyperalgesic skin of patients with reflex sympathetic dystrophy.
Gene_expression (present) of alpha 1 in skin associated with rsd and hyperalgesia
12) Confidence 0.65 Published 1996 Journal Clin. Sci. Section Abstract Doc Link 8774263 Disease Relevance 0.94 Pain Relevance 0.53
Further studies need to identify the dermal and epidermal cell types that express high densities of alpha 1-adrenoceptors, and to investigate their normal function and role in neuropathic pain.
Gene_expression (express) of alpha 1 in epidermal cell associated with neuropathic pain
13) Confidence 0.65 Published 1996 Journal Clin. Sci. Section Abstract Doc Link 8774263 Disease Relevance 0.85 Pain Relevance 0.46
alpha1,4-N-Acetylglucosaminyltransferase (alpha4GnT) is a glycosyltransferase responsible for the biosynthesis of alpha1,4-GlcNAc-capped O-glycans, and is frequently expressed in pancreatic cancer cells but not peripheral blood cells.
Neg (not) Gene_expression (expressed) of alpha1 in blood cells associated with pancreatic cancer
14) Confidence 0.65 Published 2006 Journal Cancer Sci. Section Abstract Doc Link 16441422 Disease Relevance 0.48 Pain Relevance 0.07
Electrical field stimulation induced frequency-dependent contractions which were abolished by tetrodotoxin (10(-6) M) and prazosin (10(-6) M), thus indicating that this effect was due to noradrenaline released from adrenergic nerves acting on alpha 1-adrenoceptors.
Gene_expression (acting) of alpha 1 in nerves associated with tetrodotoxin and noradrenaline
15) Confidence 0.65 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8119307 Disease Relevance 0 Pain Relevance 0.22
[Clinical value of C-reactive protein, alpha 1-glycoprotein acid and transferrin assay in homozygous sickle cell disease].
Gene_expression (acid) of alpha 1 associated with sickle cell anemia and inflammation
16) Confidence 0.65 Published 1993 Journal Bull Soc Pathol Exot Section Title Doc Link 8292921 Disease Relevance 0.50 Pain Relevance 0.37
We recently demonstrated the presence of apolipoprotein E and alpha 1-antichymotrypsin in the amyloid deposits.
Gene_expression (presence) of alpha 1 associated with amyloid plaque and disorder of lipid metabolism
17) Confidence 0.65 Published 1997 Journal Kidney Int. Suppl. Section Abstract Doc Link 9350687 Disease Relevance 1.27 Pain Relevance 0.09
Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed that the glycine receptor alpha1, alpha2, beta subunits and gephyrin mRNAs were expressed at comparable levels in strychnine-treated and untreated cultures.
Gene_expression (expressed) of alpha1
18) Confidence 0.65 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.09
Low molecular weight proteins (beta2-microglobulin, prolactin, alpha1-microglobulin, and alpha1-acid glycoprotein) were more effectively removed in this HDF system than in conventional hemodialysis (HD) using the same dialyzer as that in the HDF system, and the removal of these proteins in the HDF system was enhanced as their molecular weights increased.
Gene_expression (removed) of alpha1
19) Confidence 0.65 Published 1998 Journal Artif Organs Section Abstract Doc Link 9555959 Disease Relevance 0.08 Pain Relevance 0.08
Their antihypertensive efficacy is beyond doubt, but their profile of adverse reactions is considered unfavourable when compared with most other antihypertensive drugs currently used, such as low-dose diuretics, beta-blockers, angiotensin-converting enzymes (ACE)-inhibitors, calcium antagonists, peripheral alpha1-adrenoceptor antagonists, and angiotensin II-receptor antagonists.
Gene_expression (antagonists) of alpha1 associated with adverse drug reaction, beta blocker and antagonist
20) Confidence 0.65 Published 1999 Journal J Hypertens Suppl Section Abstract Doc Link 10489094 Disease Relevance 0.10 Pain Relevance 0.54

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