INT35946

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.92
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) endoplasmic reticulum (Clu) response to stress (Clu)
cytoplasm (Clu) cytosol (Clu) extracellular space (Clu)
Anatomy Link Frequency
bile 2
liver 1
nerve 1
smooth muscle cells 1
central nervous system 1
Clu (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 9 100.00 Very High Very High Very High
Central nervous system 6 98.16 Very High Very High Very High
ischemia 5 97.40 Very High Very High Very High
qutenza 98 95.12 Very High Very High Very High
Chronic pancreatitis 6 93.16 High High
agonist 6 91.24 High High
Calcium channel 2 87.04 High High
anesthesia 5 86.04 High High
Inflammatory response 4 79.52 Quite High
Kinase C 42 78.96 Quite High
Disease Link Frequency Relevance Heat
Injury 39 99.60 Very High Very High Very High
Diuresis 3 99.36 Very High Very High Very High
Ocular Hypertension 1 98.60 Very High Very High Very High
Cancer 7 97.68 Very High Very High Very High
Necrosis 8 97.44 Very High Very High Very High
Cv Unclassified Under Development 5 97.40 Very High Very High Very High
Optic Nerve Injuries 34 94.92 High High
Sleep Disorders 3 94.08 High High
Pancreatitis 6 93.16 High High
Apoptosis 34 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the in vitro study, clusterin mRNA and protein were strongly induced in AR4-2J cells treated either with arginine, menadione, tumor necrosis factor-alpha or transforming growth factor-beta1.
Positive_regulation (induced) of clusterin mRNA associated with necrosis and cancer
1) Confidence 0.69 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.68 Pain Relevance 0.25
Clusterin is a secretory glycoprotein that is highly induced in several tissues in response to injury.
Positive_regulation (induced) of Clusterin associated with injury
2) Confidence 0.69 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.40 Pain Relevance 0.15
Recoveries as iso-DAG and D-2G in bile were greatly enhanced (8.2 and 36.4%, respectively).
Positive_regulation (enhanced) of iso-DAG in bile associated with bile
3) Confidence 0.44 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9456294 Disease Relevance 0 Pain Relevance 0.12
Recoveries as iso-DAG and D-2G in bile were greatly enhanced (8.2 and 36.4%, respectively).
Positive_regulation (enhanced) of iso-DAG in bile associated with bile
4) Confidence 0.44 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9456294 Disease Relevance 0 Pain Relevance 0.12
At 3 hr, recoveries (in comparison to DF-dosed perfusions) were similar for DF (51.7%) and DAG (8.3%), significantly decreased for DS (10.6%) and DPG (6.4%), and significantly increased for iso-DAG (0.8%), D-2G (9.1%), and covalent adducts in perfusate (1.49%) and liver (0.30%).
Positive_regulation (increased) of iso-DAG in liver
5) Confidence 0.41 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9456294 Disease Relevance 0.06 Pain Relevance 0.18
Increases in both the TA EMG and SGP were abolished after bilateral sectioning of the recurrent laryngeal nerve.
Positive_regulation (Increases) of SGP in nerve
6) Confidence 0.40 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16645190 Disease Relevance 0.35 Pain Relevance 0.59
Glomerular filtration rate (CIn) decreased, whereas CNa and CLi increased during osmotic diuresis.
Positive_regulation (increased) of CLi associated with diuresis
7) Confidence 0.38 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8048569 Disease Relevance 0.27 Pain Relevance 0
Rats infused with 150 mM glucose instead of saline showed similar increases in CLi and UNaV, although the absolute levels were lower than in saline-infused rats.
Positive_regulation (increases) of CLi
8) Confidence 0.35 Published 1988 Journal Ren. Physiol. Biochem. Section Abstract Doc Link 3244893 Disease Relevance 0 Pain Relevance 0.22
Interestingly, clusterin, lipocalin 2, litaf, and TNFR1a are also upregulated by other injuries as elevation of intraocular pressure (IOP) or ischemia [36-40].
Positive_regulation (upregulated) of clusterin associated with ischemia, injury and ocular hypertension
9) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.94 Pain Relevance 0.12
This result suggested that GPCR-coupled DAG could serve as endogenous ligand of TRPV1 in central nervous system as well as in periphery.
Positive_regulation (coupled) of DAG in central nervous system associated with central nervous system
10) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.18 Pain Relevance 0.55
These results provide strong support for DAG acting as an endogenous ligand for TRPV1.


Positive_regulation (support) of DAG
11) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.32
activate receptors on smooth muscle cells to increase intracellular levels of inositol triphosphate (IP3) and diacylglycerol (DAG) via a phospholipase C (PLC) mediated pathway.
Positive_regulation (increase) of DAG in smooth muscle cells
12) Confidence 0.04 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 1.04 Pain Relevance 0.10

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