INT3597

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Context Info
Confidence 0.63
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 17.94
Pain Relevance 11.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Anatomy Link Frequency
sensory neurons 2
blood 2
peripheral nerve 2
gastric juice 1
epithelial cells 1
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 3 99.98 Very High Very High Very High
Peripheral nerve injury 28 99.82 Very High Very High Very High
metalloproteinase 9 99.80 Very High Very High Very High
Glutamate receptor 5 99.72 Very High Very High Very High
sSRI 91 99.60 Very High Very High Very High
Pain 90 99.34 Very High Very High Very High
dorsal root ganglion 245 99.20 Very High Very High Very High
corticosteroid 1 99.14 Very High Very High Very High
qutenza 98 99.02 Very High Very High Very High
agonist 55 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 136 99.88 Very High Very High Very High
Nervous System Injury 153 99.82 Very High Very High Very High
Pruritus 6 99.82 Very High Very High Very High
Injury 80 99.08 Very High Very High Very High
Ulcers 4 98.96 Very High Very High Very High
Ganglion Cysts 251 98.72 Very High Very High Very High
Pain 89 98.64 Very High Very High Very High
Stress 14 98.52 Very High Very High Very High
Neuropathic Pain 190 97.92 Very High Very High Very High
Nociception 66 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Involvement of free radicals followed by the activation of phospholipase A2 in the mechanism that underlies the combined effects of methamphetamine and morphine on subacute toxicity or lethality in mice: comparison of the therapeutic potential of fullerene, mepacrine, and cooling.
Positive_regulation (activation) of phospholipase A2 associated with toxicity and morphine
1) Confidence 0.63 Published 2007 Journal Toxicology Section Title Doc Link 17553606 Disease Relevance 0.32 Pain Relevance 0.41
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Positive_regulation (calcium-independent) of phospholipase A2 associated with allodynia
2) Confidence 0.44 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.24
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.
Positive_regulation (activation) of phospholipase A2 associated with qutenza and pruritus
3) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Title Doc Link 17329430 Disease Relevance 0.30 Pain Relevance 0.29
Because the metabolic products of lipoxygenases (LOs) activate transient receptor potential vanilloid receptor-1 (TRPV1) in sensory neurons, we hypothesized that histamine excites sensory neurons by activating TRPV1 via phospholipase A2 (PLA2) and LO stimulation.
Positive_regulation (activating) of phospholipase A2 in sensory neurons
4) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329430 Disease Relevance 0.24 Pain Relevance 0.09
Certain arrhythmias and ion imbalances might be caused by catecholamine activation of phospholipase A2.
Positive_regulation (activation) of phospholipase A2 associated with catecholamine
5) Confidence 0.36 Published 1975 Journal Recent Adv Stud Cardiac Struct Metab Section Abstract Doc Link 813283 Disease Relevance 0.15 Pain Relevance 0.40
Not only endogenously activated phospholipase A2 is able to split off prostaglandin precursors followed by subsequent generation of prostaglandins but also exogenously administered phospholipase A2 is able to induce the release of pain-enhancing prostaglandins.
Positive_regulation (activated) of phospholipase A2 associated with pain
6) Confidence 0.36 Published 1981 Journal Agents Actions Section Abstract Doc Link 6122358 Disease Relevance 0.49 Pain Relevance 0.56
It is well known that LPA is mainly produced via two major pathways, namely LPC conversion mediated by activation of ATX and phosphatidic acid conversion mediated by activation of phospholipase A2 (PLA2) [6,7].
Positive_regulation (activation) of phospholipase A2
7) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.16 Pain Relevance 0.75
Not only endogenously activated phospholipase A2 is able to split off prostaglandin precursors followed by subsequent generation of prostaglandins but also exogenously administered phospholipase A2 is able to induce the release of pain-enhancing prostaglandins.
Positive_regulation (activated) of phospholipase A2 associated with pain
8) Confidence 0.26 Published 1981 Journal Agents Actions Section Abstract Doc Link 6122358 Disease Relevance 0.50 Pain Relevance 0.57
CONCLUSION: These data suggest that phospholipase A2 type 2 activity is increased in proliferative phase endometrium of women with polycystic ovaries but that the increase is not associated with chronic pelvic venous congestion.


Positive_regulation (increased) of phospholipase A2 in endometrium
9) Confidence 0.16 Published 1992 Journal Br J Obstet Gynaecol Section Body Doc Link 1637765 Disease Relevance 0 Pain Relevance 0
We found that COX-2-/- mice have altered expression and activity of enzymes in the AA metabolism cascade, including increases in COX-1, cytosolic phospholipase A2 (cPLA2) and secretory phospholipase A2 expression [5].
Positive_regulation (increases) of phospholipase A2
10) Confidence 0.14 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.11
In other words, increase of [Ca2+]i activates phospholipase A2 (PLA2), simulating generation of arachidonic acid (AA), one of the free fatty acids (FFA).
Positive_regulation (activates) of phospholipase A2
11) Confidence 0.13 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.33 Pain Relevance 0.07
Some of TPA's biological actions are to enhance the release of 20:4n-6 from PL via kinase activation of phospholipase A2 and to inhibit 20:4n-6 conversion to PGE2 by inhibiting cyclooxygenase-2 [30,31].
Positive_regulation (activation) of phospholipase A2
12) Confidence 0.13 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.58 Pain Relevance 0.04
In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2.
Positive_regulation (activation) of phospholipase A2
13) Confidence 0.12 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2822744 Disease Relevance 0.10 Pain Relevance 0.05
P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain.
Positive_regulation (activation) of phospholipase A2 in sensory neurons associated with pain and neuropathic pain
14) Confidence 0.12 Published 2007 Journal J. Neurochem. Section Title Doc Link 17725579 Disease Relevance 1.00 Pain Relevance 0.96
In women with normal ovaries, both with and without chronic pelvic pain, phospholipase A2 type 2 activity was significantly higher in the secretory phase than in the proliferative phase (P less than 0.02 and P less than 0.05 respectively) but in women with polycystic ovaries, with and without chronic pelvic pain, there was no significant difference in activity between the two phases of the cycle.
Positive_regulation (higher) of phospholipase A2 in ovaries
15) Confidence 0.11 Published 1992 Journal Br J Obstet Gynaecol Section Body Doc Link 1637765 Disease Relevance 0 Pain Relevance 0
Those PAR activators induced a calcium independent phospholipase A2 with the consequent release of arachidonic acid and synthesis of prostaglandin E2 [30].
Positive_regulation (induced) of phospholipase A2
16) Confidence 0.11 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.25 Pain Relevance 0.20
Increases in intracellular Ca2+ initiate several second messenger pathways including the activation of phospholipase A2 (PLA2), phospholipase C (PLC) and Ca2+-dependent kinases, which can lead to the generation of AA and its metabolites, release of Ca2+ from intracellular stores and phosphorylation of nociceptive ion channels, respectively.
Positive_regulation (activation) of phospholipase A2 associated with nociception
17) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.54 Pain Relevance 0.53
In cultured human lung epithelial cells challenged by thrombin, APC abrogated the activation of ERK and its downstream effector, cytosolic Phospholipase A2.


Positive_regulation (activation) of Phospholipase A2 in epithelial cells
18) Confidence 0.10 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887192 Disease Relevance 0.54 Pain Relevance 0.08
The gastric juice of Helicobacter pylori-infected individuals contains substantially higher levels of phospholipase A2 (PLA2) than that of individuals who are not infected.
Positive_regulation (levels) of phospholipase A2 in gastric juice associated with ulcers
19) Confidence 0.08 Published 1998 Journal Tidsskr. Nor. Laegeforen. Section Abstract Doc Link 9748810 Disease Relevance 0.48 Pain Relevance 0.09
Cell swelling also activates phospholipase A2 (PLA2) and produces AA.
Positive_regulation (activates) of phospholipase A2 associated with pressure and volume under development
20) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 1.35 Pain Relevance 0.61

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