INT35975

Context Info Confidence 0.39 First Reported 1988 Last Reported 2010 Negated 21 Speculated 19 Reported most in Abstract Documents 109 Total Number 130 Disease Relevance 57.88 Pain Relevance 49.69

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)

Anatomy Link Frequency spinal 7 kidney 4 neurons 3 chondrocytes 2 platelet 2 Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat cINOD 389 100.00 COX2 128 100.00 Pain 109 100.00 COX-2 inhibitor 84 100.00 cOX1 62 100.00 Spinal cord 19 100.00 acular 17 100.00 agonist 13 100.00 Bioavailability 3 100.00 Inflammation 387 99.76

Disease Link Frequency Relevance Heat INFLAMMATION 540 100.00 Stress 29 100.00 Ulcers 37 99.80 Coronary Artery Disease 1 99.76 Hyperalgesia 40 99.72 Muscular Atrophy 3 99.72 Arthritis 52 99.60 Nociception 34 99.48 Pain 97 99.42 Apoptosis 28 99.42

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of our study was to investigate the effect of various cyclooxygenase (COX) inhibitors (namely, indomethacin [a nonselective COX inhibitor], nimesulide [a partially selective COX inhibitor] and celecoxib [a highly selective COX inhibitor]) on postoperative ileus in rats.

Spec (investigate) Regulation (effect) of COX associated with ileus

1) Confidence 0.39 Published 2002 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 12168503 Disease Relevance 0.24 Pain Relevance 0.16

Role of spinal cyclooxygenase (COX)-2 on thermal hyperalgesia evoked by carageenan injection in the rat.

Regulation (Role) of COX in spinal associated with thermal hyperalgesia and cox2

2) Confidence 0.38 Published 1997 Journal Neuroreport Section Title Doc Link 9243607 Disease Relevance 0.51 Pain Relevance 0.64

The purpose of the present study was to investigate the role of central cyclooxygenase (COX) pathways in the modulation of mechanical allodynia following compression of the left trigeminal ganglion.

Spec (investigate) Regulation (role) of COX in trigeminal ganglion associated with ganglion cysts, allodynia and trigeminal ganglion

3) Confidence 0.35 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19239920 Disease Relevance 0.54 Pain Relevance 0.47

The classically recognized target for NSAID action are the two isoforms of the cyclooxygenase (COX) gene, which is responsible for prostaglandin production.

Regulation (target) of COX associated with cinod

4) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.67 Pain Relevance 0.36

These COX inhibitors failed to affect the depressor responses to BK.

Neg (failed) Regulation (affect) of COX associated with bradykinin

5) Confidence 0.31 Published 2009 Journal Vascul. Pharmacol. Section Abstract Doc Link 19524064 Disease Relevance 0.40 Pain Relevance 0.52

The present study was designed to examine the influence of selective COX-2 inhibitors, such as rofecoxib and celecoxib, on gastric mucosal integrity in rats with adjuvant-induced arthritis.

Spec (examine) Regulation (influence) of COX associated with cox-2 inhibitor and arthritis

6) Confidence 0.30 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388629 Disease Relevance 0.60 Pain Relevance 0.36

Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.

Regulation (effect) of COX associated with nociception, cox2 and diclofenac

7) Confidence 0.29 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9665655 Disease Relevance 0.51 Pain Relevance 0.80

These results suggest that a selective COX-2 inhibitor is effective in the effector phase by its influence on macrophages that are responsible for nerve degeneration.

Regulation (effective) of COX in nerve associated with cox-2 inhibitor and nerve degeneration

8) Confidence 0.28 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10567084 Disease Relevance 0.39 Pain Relevance 0.47

The present study delineates the intracellular ionic milieu in the colonocytes that could generate strong apoptotic signals where DMH-induced carcinogenesis was studied in the initiation stage in rats and its regression with the COX inhibitors.

Regulation (regression) of COX associated with apoptosis

9) Confidence 0.28 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 20225762 Disease Relevance 0.56 Pain Relevance 0.39

Although DFU inhibited PGE(2) by one-third, it did not affect COX expression. 3.

Neg (not) Regulation (affect) of COX

10) Confidence 0.28 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.55 Pain Relevance 0.18

Indomethacin and SC-560 significantly inhibited prostaglandin (PG) E(2), without significantly affecting COX-1 and COX-2 expression.

Neg (without) Regulation (affecting) of COX

11) Confidence 0.28 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.56 Pain Relevance 0.13

The present study was undertaken to determine the effects of cyclooxygenase (COX) inhibitors on the development of neuropathic pain in rats following chronic constriction injury (CCI).

Spec (determine) Regulation (effects) of COX associated with eae, injury and neuropathic pain

12) Confidence 0.28 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15501312 Disease Relevance 0.75 Pain Relevance 0.34

Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats.

Regulation (Effect) of COX associated with thermal hyperalgesia and cox1

13) Confidence 0.27 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9618405 Disease Relevance 0.67 Pain Relevance 0.77

Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats.

Regulation (Effect) of COX associated with thermal hyperalgesia and cox1

14) Confidence 0.27 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9618405 Disease Relevance 0.62 Pain Relevance 0.71

METHODS: To evaluate the relative contribution of COX-1 and COX-2 in nociceptive transmission in the spinal cord, we assessed the effects of the selective COX-1 inhibitor SC 560, the selective COX-2 inhibitor celecoxib, and the nonselective COX inhibitor ketorolac on formalin-evoked behavior and spinal c-Fos-like immunoreactivity (FLI).

Regulation (contribution) of COX in spinal

15) Confidence 0.25 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292448 Disease Relevance 0 Pain Relevance 0

METHODS: To evaluate the relative contribution of COX-1 and COX-2 in nociceptive transmission in the spinal cord, we assessed the effects of the selective COX-1 inhibitor SC 560, the selective COX-2 inhibitor celecoxib, and the nonselective COX inhibitor ketorolac on formalin-evoked behavior and spinal c-Fos-like immunoreactivity (FLI).

Regulation (effects) of COX in spinal

16) Confidence 0.25 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292448 Disease Relevance 0 Pain Relevance 0

METHODS: To evaluate the relative contribution of COX-1 and COX-2 in nociceptive transmission in the spinal cord, we assessed the effects of the selective COX-1 inhibitor SC 560, the selective COX-2 inhibitor celecoxib, and the nonselective COX inhibitor ketorolac on formalin-evoked behavior and spinal c-Fos-like immunoreactivity (FLI).

Regulation (contribution) of COX in spinal

17) Confidence 0.25 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292448 Disease Relevance 0 Pain Relevance 0

METHODS: To evaluate the relative contribution of COX-1 and COX-2 in nociceptive transmission in the spinal cord, we assessed the effects of the selective COX-1 inhibitor SC 560, the selective COX-2 inhibitor celecoxib, and the nonselective COX inhibitor ketorolac on formalin-evoked behavior and spinal c-Fos-like immunoreactivity (FLI).

Regulation (effects) of COX in spinal

18) Confidence 0.25 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292448 Disease Relevance 0 Pain Relevance 0

For example, despite muscle atrophy there was no change in the activity of citrate synthase or COX, or the abundance of COX subunit mRNAs in plantaris muscle in glucocorticoid-treated rats [4], [6].

Neg (no) Regulation (change) of COX in muscle associated with muscular atrophy

19) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667640 Disease Relevance 0.38 Pain Relevance 0.04

We previously reported the effect of a cyclooxygenase (COX)-2 inhibitor, nimesulide, on experimental allergic neuritis (EAN) in both the induction and effector phases, in contrast to the usual COX inhibitor, which was effective only when administered in the induction phase.

Regulation (effect) of COX associated with experimental autoimmune neuritis and neuritis

20) Confidence 0.25 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10567084 Disease Relevance 0.33 Pain Relevance 0.40

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