INT3598

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Context Info
Confidence 0.44
First Reported 1975
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 12
Total Number 17
Disease Relevance 3.45
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Anatomy Link Frequency
iris smooth muscle 1
synovial cells 1
fibroblast 1
iris 1
ovaries 1
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 16 100.00 Very High Very High Very High
cINOD 11 100.00 Very High Very High Very High
Catecholamine 3 100.00 Very High Very High Very High
pain pelvic 2 100.00 Very High Very High Very High
opiate 1 96.92 Very High Very High Very High
withdrawal 3 96.64 Very High Very High Very High
Opioid 4 94.64 High High
agonist 18 94.20 High High
Angina 6 92.80 High High
Inflammatory stimuli 4 92.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 102 100.00 Very High Very High Very High
Reprotox - General 3 2 100.00 Very High Very High Very High
Gastritis 3 98.68 Very High Very High Very High
Polycystic Ovary Syndrome 2 98.62 Very High Very High Very High
Myocardial Infarction 3 95.40 Very High Very High Very High
Stress 20 94.72 High High
Cv General 3 Under Development 6 92.80 High High
Nerve Root Compression 1 88.12 High High
Hyperalgesia 1 87.68 High High
Alzheimer's Dementia 2 77.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of the anti-inflammatory drugs, indomethacin and aspirin, and the phospholipase A2 inhibitors, p-bromophenacyl bromide and mepacrine, on the in vitro metabolism of [1-14C]arachidonic acid by rabbit iris smooth muscle and iris microsomes were investigated.
Spec (investigated) Regulation (effects) of phospholipase A2 in iris associated with aspirin, inflammation and cinod
1) Confidence 0.44 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6809058 Disease Relevance 0.17 Pain Relevance 0.23
EB-382 exhibited a dose-dependent inhibitory effect on the phospholipase A2 activity in 3T3 mouse fibroblast cells with a different mechanism from steroidal agents, although indomethacin and ibuprofen did not reveal any significant inhibition.
Regulation (effect) of phospholipase A2 in fibroblast
2) Confidence 0.43 Published 1989 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2787705 Disease Relevance 0.31 Pain Relevance 0.56
Altered regulation of phospholipase A2 activity in rheumatic synovia could explain the observed differences between healthy and rheumatic synovial cells.
Regulation (regulation) of phospholipase A2 in synovial cells
3) Confidence 0.30 Published 1989 Journal Agents Actions Section Abstract Doc Link 2786669 Disease Relevance 0.15 Pain Relevance 0.19
OBJECTIVES: To determine correlations between herniated disc phospholipase A2 and clinical, radiographic, and anatomic signs of common sciatica; to evaluate serum phospholipase A2 activity as a marker of disc phospholipase A2; and to investigate the in vivo effect of piroxicam on disc phospholipase A2.
Regulation (effect) of phospholipase A2
4) Confidence 0.26 Published 1997 Journal Spine Section Body Doc Link 9322315 Disease Relevance 0.09 Pain Relevance 0
We have examined changes in the activities of phospholipase A2 (PLA2) and the concentrations of total choline-phospholipids and lysolecithin, in serum from patients following a myocardial infarction by comparison with patients suffering from unstable angina.
Spec (examined) Regulation (changes) of phospholipase A2 associated with angina and myocardial infarction
5) Confidence 0.25 Published 1992 Journal Clin. Chim. Acta Section Abstract Doc Link 1576747 Disease Relevance 0.54 Pain Relevance 0.16
OBJECTIVE: To compare the activity of calcium independent phospholipase A2 in the endometrium of women with polycystic ovaries and in women with normal ovaries, and to investigate the influence of chronic pelvic pain on phospholipase A2 activity.
Spec (investigate) Regulation (influence) of phospholipase A2 in ovaries associated with pain pelvic and polycystic ovary syndrome
6) Confidence 0.16 Published 1992 Journal Br J Obstet Gynaecol Section Abstract Doc Link 1637765 Disease Relevance 0.35 Pain Relevance 0.17
The effects of the anti-inflammatory drugs, indomethacin and aspirin, and the phospholipase A2 inhibitors, p-bromophenacyl bromide and mepacrine, on the in vitro metabolism of [1-14C]arachidonic acid by rabbit iris smooth muscle and iris microsomes were investigated.
Spec (investigated) Regulation (effects) of phospholipase A2 in iris smooth muscle associated with aspirin, inflammation and cinod
7) Confidence 0.15 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6809058 Disease Relevance 0.17 Pain Relevance 0.23
The effect of catecholamines, represented by epinephrine and norepinephrine, on the activity of phospholipase A2 from bee venom was studied.
Regulation (effect) of phospholipase A2 associated with catecholamine
8) Confidence 0.14 Published 1975 Journal Recent Adv Stud Cardiac Struct Metab Section Abstract Doc Link 813283 Disease Relevance 0.15 Pain Relevance 0.24
Phospholipase A2 is potentially an important target for structure-based rational drug design.
Regulation (target) of Phospholipase A2
9) Confidence 0.14 Published 2005 Journal J Drug Target Section Abstract Doc Link 15823962 Disease Relevance 0.16 Pain Relevance 0.40
by a mechanism dependent on phospholipase A2 activation [42, 43].
Regulation (dependent) of phospholipase A2
10) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.15 Pain Relevance 0.05
The effects of phospholipase A2, cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase inhibitors on acute opiate withdrawal induced by selective mu, kappa and delta receptor agonists was investigated in vitro.
Spec (investigated) Regulation (effects) of phospholipase A2 associated with agonist, opiate and withdrawal
11) Confidence 0.09 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10465690 Disease Relevance 0 Pain Relevance 0.49
Various cellular mediators regulate nSMase activity including anionic phospholipids, protein kinases phospholipase A2, caveolin, Bcl-2 and Bcl-xL and proteases [5], [7], [8].
Regulation (regulate) of phospholipase A2
12) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.61 Pain Relevance 0.11
The best described signaling properties reported for C1P include, on the one hand, a positive effect on cell proliferation and cell survival [4,5] and, on the other hand, the control of cytosolic phospholipase A2 (cPLA2) activity [6-9].
Regulation (control) of phospholipase A2
13) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.15 Pain Relevance 0
Prostaglandin synthesis is regulated at multiple steps, including: (1) phospholipase A2, which releases arachidonic acid from membrane phospholipids; (2) PGH synthase (PGHS), which converts arachidonic acid to the endoperoxides PGG2 and PGH2; and (3) PG synthases convert the endoperoxides to PGI2, PGE2, and others.
Regulation (regulated) of phospholipase A2
14) Confidence 0.05 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631046 Disease Relevance 0.09 Pain Relevance 0.18
Effect of ranitidine bismuth citrate on the phospholipase A2 activity of Naja naja venom and Helicobacter pylori: a biochemical analysis.
Regulation (Effect) of phospholipase A2 associated with gastritis
15) Confidence 0.05 Published 1999 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 10383521 Disease Relevance 0.29 Pain Relevance 0.18
The role of phospholipids was studied, using the effect of phospholipase A2 and membrane reconstitution.
Regulation (effect) of phospholipase A2
16) Confidence 0.05 Published 1993 Journal Comp. Biochem. Physiol., B Section Abstract Doc Link 8386995 Disease Relevance 0 Pain Relevance 0.33
In addition, their ligand-binding inhibitory activity depended on their phospholipase A2 activity.
Regulation (depended) of phospholipase A2
17) Confidence 0.02 Published 2000 Journal Eur. J. Biochem. Section Abstract Doc Link 10691971 Disease Relevance 0.05 Pain Relevance 0.39

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