INT35983

Context Info Confidence 0.09 First Reported 1988 Last Reported 2001 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.92 Pain Relevance 0.43

transferase activity, transferring glycosyl groups (fut10) Golgi apparatus (fut10)

Anatomy Link Frequency PGE2 2 fut10 (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 4 97.56 antagonist 3 87.52 anesthesia 3 77.52

Disease Link Frequency Relevance Heat Injury 6 99.68 Brain Injury 8 99.52 Convulsion 8 98.96 Acute Renal Failure 2 82.16 Decapitation 2 75.40 Nephrotoxicity 2 75.00 Increased Venous Pressure Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, fluid percussion brain injury results in substantial elevations in PGE2 and TxB2 levels and posttraumatic seizures exacerbate the observed increases.

Positive_regulation (elevations) of TxB2 in PGE2 associated with convulsion and brain injury

1) Confidence 0.09 Published 1988 Journal J. Neurotrauma Section Abstract Doc Link 3249309 Disease Relevance 0.83 Pain Relevance 0.09

Fifteen minutes after injury, both PGE2 and TxB2 levels remained elevated but the levels were lower than at 5 min in the rats that did not exhibit posttraumatic seizures.

Positive_regulation (elevated) of TxB2 in PGE2 associated with convulsion and injury

2) Confidence 0.05 Published 1988 Journal J. Neurotrauma Section Abstract Doc Link 3249309 Disease Relevance 0.86 Pain Relevance 0.14

Serum thromboxane B2 (TxB2) concentration did not increase by treatment with CsA.

Neg (not) Positive_regulation (increase) of TxB2

3) Confidence 0.00 Published 2001 Journal Life Sci. Section Abstract Doc Link 11228102 Disease Relevance 0.23 Pain Relevance 0.19

General Comments

This test has worked.