INT35990

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 4.47
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular amino acid metabolic process (Sds)
cytoplasm (Sds)
Anatomy Link Frequency
neurons 2
spinal cord 1
Sds (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 10 99.56 Very High Very High Very High
Morphine 5 99.28 Very High Very High Very High
Cannabinoid 152 99.18 Very High Very High Very High
Paracetamol 10 98.52 Very High Very High Very High
Spinal cord 187 97.16 Very High Very High Very High
medulla 19 96.40 Very High Very High Very High
Dorsal horn 192 96.12 Very High Very High Very High
narcan 3 92.72 High High
antagonist 45 92.32 High High
addiction 2 90.88 High High
Disease Link Frequency Relevance Heat
Porphyria 76 99.96 Very High Very High Very High
Targeted Disruption 73 99.58 Very High Very High Very High
Poisoning 2 99.56 Very High Very High Very High
Necrosis 4 99.32 Very High Very High Very High
Tyrosinemia 2 97.20 Very High Very High Very High
Syndrome 6 96.20 Very High Very High Very High
Hepatic Porphyrias 20 95.32 Very High Very High Very High
Disease 116 94.28 High High
Hereditary Coproporphyria 2 92.00 High High
Morphine Dependence 1 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a progressive inhibition of SDH upto six days of morphine treatment.
Negative_regulation (inhibition) of SDH associated with morphine
1) Confidence 0.49 Published 1988 Journal Acta Neurol Belg Section Abstract Doc Link 3252685 Disease Relevance 0.09 Pain Relevance 0.93
In mouse, Gly- and GABAARs with differing physiological properties contribute to fast synaptic inhibition in the SDH and DDH.
Negative_regulation (inhibition) of SDH
2) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.26
In contrast to the marked difference in the contribution of GlyRs to inhibition in the SDH and DDH, GABAAR-mediated inhibition appears equally important in both spinal cord regions.
Negative_regulation (inhibition) of SDH in spinal cord associated with spinal cord
3) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.08 Pain Relevance 0.21
Together these data show that Gly- and GABAARs with clearly differing physiological properties and cannabinoid-sensitivity contribute to fast synaptic inhibition in mouse SDH and DDH.



Negative_regulation (inhibition) of SDH associated with cannabinoid
4) Confidence 0.31 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.09
We also found almost all neurons received GlyR-mediated mIPSCs in the mouse DDH, however, the properties of GlyRs differed markedly in SDH versus DDH.
Negative_regulation (differed) of SDH in neurons
5) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.22
In both SDH and DDH neurons methAEA reduced mIPSC frequency and did not alter mIPSC amplitude.
Negative_regulation (reduced) of SDH in neurons
6) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.06 Pain Relevance 0.34
subunits dominate in both SDH and DDH, expression of the ?
Negative_regulation (dominate) of SDH
7) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.08 Pain Relevance 0.36
Our qPCR data for GlyR subunits show that the balance of GlyR-subunit expression differs in SDH and DDH.
Negative_regulation (differs) of SDH
8) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.29
We found no evidence for a 'direct effect' of methAEA on GlyR function in either SDH or DDH.
Negative_regulation (effect) of SDH
9) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.21 Pain Relevance 0.73
Structurally, the GABAB1a and GABAB1b isoforms solely
differ in their N-terminal ectodomain by a tandem pair of SDs that are present
in GABAB1a but not in GABAB1b
(18,
19). 
Negative_regulation (pair) of SDs
10) Confidence 0.24 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.31 Pain Relevance 0.09
YGW dramatically abolished the elevated activities of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) and reduced the necrosis induced by AlOH.
Negative_regulation (abolished) of SDH associated with necrosis and alcohol
11) Confidence 0.22 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10999434 Disease Relevance 0.26 Pain Relevance 0.68
YGW also decreased the elevated activities of ALT and SDH and reduced the necrosis induced by AA and CCl4.
Negative_regulation (decreased) of SDH associated with necrosis and paracetamol
12) Confidence 0.22 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10999434 Disease Relevance 0.27 Pain Relevance 0.67
First, we compared the activity of the mitochondrial enzyme succinate dehydrogenase (SDH) between the transgenic and wild-type animals, because SOD2 knockout is known to cause a decrease in SDH activity [37,38].
Negative_regulation (decrease) of SDH associated with targeted disruption
13) Confidence 0.19 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.40 Pain Relevance 0
poisoning due to lead-mediated inhibition of ALA dehydratase, and
Negative_regulation (inhibition) of dehydratase associated with poisoning
14) Confidence 0.00 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 0.77 Pain Relevance 0.08
rare Doss porphyria (deficiency of ALA dehydratase, EC 4.2.1.24),
Negative_regulation (deficiency) of dehydratase associated with porphyria
15) Confidence 0.00 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 1.95 Pain Relevance 0

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