INT35992

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Context Info
Confidence 0.52
First Reported 1988
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.14
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular amino acid metabolic process (Sds)
cytoplasm (Sds)
Anatomy Link Frequency
spinal cord 1
dorsal horn 1
medulla oblongata 1
adult mouse 1
Sds (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 30 100.00 Very High Very High Very High
GABAergic 11 100.00 Very High Very High Very High
Paracetamol 17 99.80 Very High Very High Very High
Morphine 10 99.60 Very High Very High Very High
addiction 4 99.24 Very High Very High Very High
Glutamate 20 98.36 Very High Very High Very High
antagonist 15 97.84 Very High Very High Very High
narcan 6 97.32 Very High Very High Very High
Spinal cord 31 94.24 High High
medulla 8 93.60 High High
Disease Link Frequency Relevance Heat
Morphine Dependence 2 99.60 Very High Very High Very High
Cognitive Disorder 4 96.80 Very High Very High Very High
Targeted Disruption 2 95.76 Very High Very High Very High
Nociception 5 94.96 High High
Toxicity 4 90.12 High High
Necrosis 2 86.08 High High
Depression 6 84.32 Quite High
Hepatotoxicity 1 77.52 Quite High
Neurological Disease 2 38.08 Quite Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in succinic dehydrogenase (SDH), during morphine dependence development, normal and antagonists (naloxone and naltrexone) precipitated withdrawals, have been analysed in the spinal cord and medulla oblongata of mice.
Regulation (Changes) of SDH in spinal cord associated with medulla, addiction, antagonist, narcan, spinal cord and morphine
1) Confidence 0.52 Published 1988 Journal Acta Neurol Belg Section Abstract Doc Link 3252685 Disease Relevance 0.10 Pain Relevance 0.76
Interestingly, the combined effect of smaller slow decaying mIPSCs in the SDH and larger fast decaying mIPSCs in the DDH resulted in a similar charge transfer per mIPSC in the two regions (364.5 ± 57.7 vs. 456.6 ± 39.9 pA.ms).
Regulation (effect) of SDH
2) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.17
In this study, we investigated whether GABAergic neurons in the superficial dorsal horn (SDH) express functional 5-HT3 receptors and how these 5-HT3 receptors affect GABAergic inhibitory synaptic transmission in the SDH, by using slice preparations from adult glutamate decarboxylase 67-green fluorescent protein (GAD67-GFP) knock-in mice.
Regulation (affect) of SDH in dorsal horn associated with targeted disruption, glutamate, gabaergic and dorsal horn
3) Confidence 0.26 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19369358 Disease Relevance 0.10 Pain Relevance 0.80
By contrast, SDH and BUN values for APAP/RIB-treated mice were not different from controls, 0 U/ml and 31 mg/dl, respectively.
Regulation (values) of SDH associated with paracetamol
4) Confidence 0.24 Published 2000 Journal Toxicol Pathol Section Abstract Doc Link 11026606 Disease Relevance 0.49 Pain Relevance 1.18
A possible role of Ca(2+)-permeable-AMPARs in synaptic strengthening has been suggested in postnatal DH cultures, but their role in the long-lasting activity-dependent synaptic plasticity of primary afferent neurotransmission in the adult mouse SDH has not been investigated.
Regulation (role) of SDH in adult mouse
5) Confidence 0.22 Published 2008 Journal Pain Section Abstract Doc Link 17826911 Disease Relevance 0.26 Pain Relevance 0.29
Changes in succinic dehydrogenase (SDH), during morphine dependence development, normal and antagonists (naloxone and naltrexone) precipitated withdrawals, have been analysed in the spinal cord and medulla oblongata of mice.
Regulation (Changes) of SDH in medulla oblongata associated with medulla, addiction, antagonist, narcan, spinal cord and morphine
6) Confidence 0.18 Published 1988 Journal Acta Neurol Belg Section Abstract Doc Link 3252685 Disease Relevance 0.10 Pain Relevance 0.76
Of importance
for drug discovery, our data also demonstrate that it is possible to
selectively impair GABAB heteroreceptors by targeting their
SDs.



Regulation (targeting) of SDs
7) Confidence 0.15 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.06
Our experiments now
directly show that this is possible by targeting the SDs.


Spec (possible) Regulation (targeting) of SDs
8) Confidence 0.15 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.10 Pain Relevance 0.03

General Comments

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