INT35993

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.75
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aldh5a1) oxidoreductase activity (Aldh5a1)
Anatomy Link Frequency
amniotic fluid 2
spinal cord 1
medulla oblongata 1
Aldh5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 16 99.98 Very High Very High Very High
Morphine 10 99.40 Very High Very High Very High
addiction 4 99.04 Very High Very High Very High
gABA 204 98.46 Very High Very High Very High
antagonist 16 97.64 Very High Very High Very High
narcan 6 97.12 Very High Very High Very High
Spinal cord 6 94.04 High High
medulla 6 93.40 High High
Glutamate 20 88.16 High High
tolerance 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 2 99.40 Very High Very High Very High
Encephalopathy 8 87.88 High High
Convulsion 36 84.36 Quite High
Frailty 4 80.96 Quite High
Congenital Anomalies 24 77.20 Quite High
Muscle Hypotonia 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Failure To Thrive 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in succinic dehydrogenase (SDH), during morphine dependence development, normal and antagonists (naloxone and naltrexone) precipitated withdrawals, have been analysed in the spinal cord and medulla oblongata of mice.
Regulation (Changes) of succinic dehydrogenase in spinal cord associated with medulla, addiction, antagonist, narcan, spinal cord and morphine
1) Confidence 0.60 Published 1988 Journal Acta Neurol Belg Section Abstract Doc Link 3252685 Disease Relevance 0.10 Pain Relevance 0.76
The finding of elevated embryonic GABA concentrations suggested that amniotic fluid derived from human pregnancies affected with SSADH (Aldh5a1) deficiency might also demonstrate elevated GABA.
Regulation (affected) of Aldh5a1 in amniotic fluid associated with gaba
2) Confidence 0.41 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0 Pain Relevance 0.41
The finding of elevated embryonic GABA concentrations suggested that amniotic fluid derived from human pregnancies affected with SSADH (Aldh5a1) deficiency might also demonstrate elevated GABA.
Regulation (affected) of SSADH in amniotic fluid associated with gaba
3) Confidence 0.41 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0 Pain Relevance 0.41
Whether this has an adverse or positive effect on phenotypic outcome in Aldh5a1-/- mice remains to be determined.


Spec (Whether) Regulation (effect) of Aldh5a1
4) Confidence 0.36 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.23 Pain Relevance 0.13
Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development

Background

Regulation (alterations) of SSADH associated with neurotransmitter
5) Confidence 0.25 Published 2008 Journal BMC Dev Biol Section Title Doc Link PMC2642797 Disease Relevance 0.32 Pain Relevance 0.18
Changes in succinic dehydrogenase (SDH), during morphine dependence development, normal and antagonists (naloxone and naltrexone) precipitated withdrawals, have been analysed in the spinal cord and medulla oblongata of mice.
Regulation (Changes) of succinic dehydrogenase in medulla oblongata associated with medulla, addiction, antagonist, narcan, spinal cord and morphine
6) Confidence 0.20 Published 1988 Journal Acta Neurol Belg Section Abstract Doc Link 3252685 Disease Relevance 0.10 Pain Relevance 0.76

General Comments

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