INT35998

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 16.16
Pain Relevance 16.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sensory neurons 6
neurons 6
skin 4
lung 4
liver 2
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 181 100.00 Very High Very High Very High
qutenza 109 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
mu opioid receptor 5 100.00 Very High Very High Very High
Nerve growth factor 11 99.80 Very High Very High Very High
Thermal hyperalgesia 5 99.76 Very High Very High Very High
Analgesic 3 99.72 Very High Very High Very High
dorsal root ganglion 8 99.68 Very High Very High Very High
Neuropeptide 30 99.48 Very High Very High Very High
trigeminal ganglion 75 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 15 99.76 Very High Very High Very High
Hypoxia 21 99.46 Very High Very High Very High
Acanthosis 12 99.40 Very High Very High Very High
Sprains And Strains 9 99.36 Very High Very High Very High
Ganglion Cysts 107 99.32 Very High Very High Very High
INFLAMMATION 32 99.18 Very High Very High Very High
Cv Unclassified Under Development 2 98.60 Very High Very High Very High
Insulin Resistance 2 98.52 Very High Very High Very High
Apoptosis 18 98.44 Very High Very High Very High
Neuropathic Pain 52 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased synthesis of calcitonin gene-related peptide stimulates keratinocyte proliferation in murine UVB-irradiated skin.
Positive_regulation (Increased) of Gene_expression (synthesis) of calcitonin gene-related peptide in skin associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.70 Published 2002 Journal J. Dermatol. Sci. Section Title Doc Link 11858952 Disease Relevance 0.24 Pain Relevance 0.57
Repeated ultraviolet (UV) irradiations have been shown to induce keratinocyte proliferation with acanthosis, stimulate the cutaneous nerve proliferation, and increase the synthesis of calcitonin gene-related peptide (CGRP).
Positive_regulation (increase) of in nerve Gene_expression (synthesis) of CGRP in keratinocyte associated with acanthosis and calcitonin gene-related peptide
2) Confidence 0.70 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.25 Pain Relevance 0.35
In addition, CGRP expression was up-regulated in the peripheral nerves of the upper dermis and lower epidermis.
Positive_regulation (up-regulated) of Gene_expression (expression) of CGRP in upper associated with calcitonin gene-related peptide
3) Confidence 0.70 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.27 Pain Relevance 0.46
Moreover, these data suggest that adenoviral gene transfer of CGRP to the lung results in expression of the gene product in non-neural tissue.
Positive_regulation (transfer) of Gene_expression (transfer) of CGRP in lung associated with calcitonin gene-related peptide
4) Confidence 0.70 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.60 Pain Relevance 0.40
The increase in pulmonary arterial pressure (PAP), PVR, right ventricular mass, and pulmonary vascular remodeling in response to chronic hypoxia was attenuated in animals overexpressing CGRP, whereas systemic arterial pressure was not altered.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CGRP associated with hypoxia and calcitonin gene-related peptide
5) Confidence 0.70 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.67 Pain Relevance 0.48
These data show that in vivo transfer of the CGRP gene to the lung attenuates the increase in PVR, right ventricular mass, and pulmonary vascular remodeling in chronically hypoxic mice with little effect on the systemic circulation.
Positive_regulation (transfer) of Gene_expression (transfer) of CGRP gene in lung associated with hypoxia and calcitonin gene-related peptide
6) Confidence 0.70 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.66 Pain Relevance 0.49
During liver injury CGRP receptor expression was increased whereas hepatic CGRP concentrations concomitantly decreased.
Positive_regulation (increased) of Gene_expression (expression) of CGRP in liver
7) Confidence 0.64 Published 2009 Journal J. Hepatol. Section Body Doc Link 19464067 Disease Relevance 0.07 Pain Relevance 0
A 5- or 30-min incubation of synaptosomes with calcitonin gene-related peptide (CGRP) (10(-6), 10(-7), 10(-8) M) produced increases in 45Ca++ uptake upon depolarization of the synaptosomes, whereas a naloxone-reversible decrease in 45Ca++ uptake was seen after a 1-hr incubation with CGRP.
Positive_regulation (increases) of Gene_expression (produced) of CGRP associated with narcan and calcitonin gene-related peptide
8) Confidence 0.50 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3257266 Disease Relevance 0 Pain Relevance 0.70
Repeated ultraviolet (UV) irradiations have been shown to induce keratinocyte proliferation with acanthosis, stimulate the cutaneous nerve proliferation, and increase the synthesis of calcitonin gene-related peptide (CGRP).
Positive_regulation (increase) of in nerve Gene_expression (synthesis) of calcitonin gene-related peptide in keratinocyte associated with acanthosis and calcitonin gene-related peptide
9) Confidence 0.50 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.25 Pain Relevance 0.35
The present data indicate a novel mechanism for enhancing P2X(3) receptor expression and function in trigeminal sensory neurons by CGRP via CREB phosphorylation.
Positive_regulation (enhancing) of Gene_expression (expression) of CGRP in sensory neurons associated with calcitonin gene-related peptide
10) Confidence 0.48 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.07 Pain Relevance 0.44
Fifty percent ethanol containing capsaicin immediately increased intragastric levels of CGRP in wild-type (WT) mice, although 50% ethanol alone did not.
Positive_regulation (increased) of Gene_expression (levels) of CGRP
11) Confidence 0.47 Published 2008 Journal Gastroenterology Section Body Doc Link 18054007 Disease Relevance 0.24 Pain Relevance 0
We have previously shown that, in AKR and C57BL/6 mice, a genetic polymorphism results in differential expression of the peptide, calcitonin gene-related polypeptide (CGRP), explaining a strain difference in thermal pain sensitivity.
Positive_regulation (results) of Gene_expression (expression) of CGRP associated with pain, sprains and strains and calcitonin gene-related peptide
12) Confidence 0.45 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 19381879 Disease Relevance 0.56 Pain Relevance 0.77
These results suggest that: (1) early expression of the CGRP phenotype is regulated in a cell-autonomous way in developing mouse DRG neurons in vitro; and (2) the RTX-induced increase in CGRP biosynthesis is most likely the result of activating the capsaicin/RTX receptor rather than directly activating the protein kinase C (PKC) pathway in vitro.
Positive_regulation (increase) of Gene_expression (biosynthesis) of CGRP in neurons associated with dorsal root ganglion, kinase c, qutenza and calcitonin gene-related peptide
13) Confidence 0.44 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7955356 Disease Relevance 0.31 Pain Relevance 0.87
Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury.
Positive_regulation (increases) of Gene_expression (Deletion) of gene-related peptide in heart associated with reperfusion injury, ischemia and calcitonin gene-related peptide
14) Confidence 0.44 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 18192222 Disease Relevance 0.88 Pain Relevance 0.69
We recently reported that isoflavone, a phytoestrogen, increases production of CGRP by increasing its transcription in sensory neurons.
Positive_regulation (increases) of Gene_expression (production) of CGRP in sensory neurons associated with calcitonin gene-related peptide
15) Confidence 0.43 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17569567 Disease Relevance 0.24 Pain Relevance 0.45
These results indicate that the deletion of the Y1 receptor causes increased release and compensatory increased synthesis of calcitonin gene-related peptide and substance P in dorsal root ganglion neurons.
Positive_regulation (causes) of Gene_expression (synthesis) of calcitonin in neurons associated with ganglion cysts, root ganglion neuron, substance p and calcitonin gene-related peptide
16) Confidence 0.43 Published 2006 Journal Neuroscience Section Abstract Doc Link 16564642 Disease Relevance 1.03 Pain Relevance 1.22
These results indicate that the deletion of the Y1 receptor causes increased release and compensatory increased synthesis of calcitonin gene-related peptide and substance P in dorsal root ganglion neurons.
Positive_regulation (increased) of Gene_expression (synthesis) of calcitonin in neurons associated with ganglion cysts, root ganglion neuron, substance p and calcitonin gene-related peptide
17) Confidence 0.43 Published 2006 Journal Neuroscience Section Abstract Doc Link 16564642 Disease Relevance 1.01 Pain Relevance 1.20
We found a significant reduction in the CFA induced increase in CGRP immunoreactive neurones as well as in CGRP gene expression in nNOS deficient mice, whereas the percentage of cells immunopositive for tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unchanged.
Positive_regulation (increase) of Gene_expression (expression) of CGRP gene associated with necrosis, cancer and calcitonin gene-related peptide
18) Confidence 0.43 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17395508 Disease Relevance 0.78 Pain Relevance 0.71
We found a significant reduction in the CFA induced increase in CGRP immunoreactive neurones as well as in CGRP gene expression in nNOS deficient mice, whereas the percentage of cells immunopositive for tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unchanged.
Positive_regulation (increase) of Gene_expression (neurones) of CGRP associated with necrosis, cancer and calcitonin gene-related peptide
19) Confidence 0.40 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17395508 Disease Relevance 0.78 Pain Relevance 0.71
Isoflavone, a phytoestrogen, increases CGRP production by increasing its transcription in sensory neurons.
Positive_regulation (increases) of Gene_expression (production) of CGRP in sensory neurons associated with calcitonin gene-related peptide
20) Confidence 0.32 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.67 Pain Relevance 0.49

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