INT35999

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Context Info
Confidence 0.65
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.12
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNAB2) transmembrane transport (KCNAB2) cytoplasm (KCNAB2)
Anatomy Link Frequency
erythrocyte 1
muscle 1
band 1
head 1
KCNAB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 59 100.00 Very High Very High Very High
Pain 46 99.60 Very High Very High Very High
narcan 1 95.96 Very High Very High Very High
anesthesia 1 93.36 High High
Morphine 5 92.84 High High
withdrawal 1 88.00 High High
Opioid 3 87.56 High High
mu opioid receptor 2 75.00 Quite High
Inflammation 21 73.36 Quite High
sodium channel 13 72.48 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 39 99.80 Very High Very High Very High
Pain 18 99.60 Very High Very High Very High
Myalgia 9 99.56 Very High Very High Very High
Adult Respiratory Distress Syndrome 92 99.04 Very High Very High Very High
Bordatella Infection 1 96.52 Very High Very High Very High
Serum Sickness 13 93.12 High High
Proteinuria 1 90.88 High High
Cv General 4 Under Development 14 90.60 High High
Hematuria 1 89.84 High High
Hemoglobinuria 1 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After subacute treatment, decrease was seen in the theta, and increase in the beta-2 and gamma, band of the spontaneous activity, dissimilarly in the cortical vs. subcortical sites.
Positive_regulation (increase) of beta-2 in band
1) Confidence 0.65 Published 2005 Journal Arh Hig Rada Toksikol Section Abstract Doc Link 16370511 Disease Relevance 0.15 Pain Relevance 0.09
However, beta-2 activity increased consistently throughout the five trials of muscle pain compared to baseline.
Positive_regulation (increased) of beta-2 in muscle associated with pain and myalgia
2) Confidence 0.25 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12576151 Disease Relevance 1.41 Pain Relevance 1.47
Comparing the EEG changes between baseline, non-painful and painful stimulations as well as waning pain, we found that the increase in beta-2 activity during muscle pain was significant over the extensive areas of the head, whereas a significant increase in alpha-2 activity took place at the posterior part of the head during waning pain following a marked decrease in overt pain.
Positive_regulation (increase) of beta-2 in head associated with pain and myalgia
3) Confidence 0.13 Published 2001 Journal Exp Brain Res Section Abstract Doc Link 11713631 Disease Relevance 0.62 Pain Relevance 1.77
First, if inhaled beta-2 agonists are to be effective for edema clearance in ALI, then there must be therapeutic levels in the alveolae.
Positive_regulation (effective) of beta-2 associated with pressure and volume under development, agonist and adult respiratory distress syndrome
4) Confidence 0.03 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 1.35 Pain Relevance 0.29
Acute phase reactants increased: erythrocyte sedimentation rate, C-reactive protein and beta-2 microglobulin.
Positive_regulation (increased) of beta-2 in erythrocyte
5) Confidence 0.02 Published 1988 Journal Medicine (Baltimore) Section Abstract Doc Link 3257288 Disease Relevance 1.34 Pain Relevance 0.03
Investigation into the mechanism leading to up-regulation of AC revealed a 40% increase in the number of beta-2 ARs as assessed by [125I]-cyanopindolol binding experiments.
Positive_regulation (increase) of beta-2
6) Confidence 0.02 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.25 Pain Relevance 0.66

General Comments

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