INT36000

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.94
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNFRSF25) signal transduction (TNFRSF25) extracellular region (TNFRSF25)
plasma membrane (TNFRSF25)
Anatomy Link Frequency
SK-N-MC 1
lymphocytes 1
mononuclear cells 1
TNFRSF25 (Homo sapiens)
TNFRSF25 - L155V (1)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.04 Very High Very High Very High
Pain 5 80.48 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 100.00 Very High Very High Very High
Apoptosis 21 98.90 Very High Very High Very High
Stress 8 94.80 High High
Hyperthyroxinemia 1 92.32 High High
Hyperthyroidism 5 90.52 High High
Lactic Acidosis 30 86.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 85.36 High High
Neuroblastoma 24 83.68 Quite High
Disease 1 80.28 Quite High
Toxicity 9 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In another case-control study, the HLA-DR3 antigen was present in more case subjects (39 percent) than control subjects (14 percent).
Gene_expression (present) of DR3
1) Confidence 0.58 Published 1988 Journal Am. J. Med. Section Abstract Doc Link 3257352 Disease Relevance 0.40 Pain Relevance 0.08
Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis.
Gene_expression (expression) of death receptor in lymphocytes associated with endogenous opioid, apoptosis and death
2) Confidence 0.55 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615182 Disease Relevance 0.94 Pain Relevance 0.27
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Gene_expression (expression) of DR3 (L155V)
3) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0
Thus, on DR3 and DR5, RXR occupies the 5?
Gene_expression (occupies) of DR3
4) Confidence 0.36 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
The VDRE was cloned upstream of the thymidine kinase (TK) promoter of pBL-CAT8+ to give DR3-TK (27).
Gene_expression (give) of DR3
5) Confidence 0.36 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
2 and the DR3-containing promoters, DREAM was less effective in GH4C1 cells and again did not stimulate the promoter activity in SK-N-MC cells that contain high endogenous DREAM levels.
Gene_expression (promoters) of DR3-containing in SK-N-MC
6) Confidence 0.31 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.30 Pain Relevance 0
In B-lymphoid cell types [38,39] and peripheral blood mononuclear cells [40], azidothymidine can trigger apoptosis and inhibition of the cell cycle [39] associated with overexpression of the death domain receptor Fas [40], although it is established that mitochondrial apoptosis can be responsible for an increased lactate production [41].


Gene_expression (overexpression) of death domain receptor in mononuclear cells associated with apoptosis and death
7) Confidence 0.06 Published 2003 Journal Crit Care Section Body Doc Link PMC270672 Disease Relevance 1.23 Pain Relevance 0

General Comments

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