INT36002

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Context Info
Confidence 0.29
First Reported 1988
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
plasma 2
Crh (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 99.76 Very High Very High Very High
mu opioid receptor 1 99.08 Very High Very High Very High
Opioid 4 98.90 Very High Very High Very High
opioid receptor 4 96.64 Very High Very High Very High
narcan 5 77.80 Quite High
Endogenous opioid 2 75.00 Quite High
Intracerebroventricular 1 60.08 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A third experiment, in which short term castrates were pretreated with an opioid antibody and then with CRF, resulted in a significant reduction of the CRF-induced reduction of serum LH levels.
Negative_regulation (reduction) of CRF Negative_regulation (reduction) of serum LH associated with opioid
1) Confidence 0.29 Published 1988 Journal Endocrinology Section Abstract Doc Link 3257730 Disease Relevance 0 Pain Relevance 0.53
In contrast, bilateral administration of beta-Funaltrexamine (antagonist of mu-opioid receptors) or naloxonazine (mu 1-antagonist) partially attenuated the inhibitory effect of rCRF on plasma LH levels.
Negative_regulation (attenuated) of rCRF Negative_regulation (effect) of LH in plasma associated with antagonist and mu opioid receptor
2) Confidence 0.13 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.66 Pain Relevance 0.43

General Comments

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