INT36003

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Crh (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.66 Very High Very High Very High
narcan 6 95.36 Very High Very High Very High
Intracerebroventricular 1 93.52 High High
Opioid 4 91.32 High High
opiate 1 78.84 Quite High
opioid receptor 2 72.48 Quite High
antagonist 1 71.20 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that CRF attenuates LH secretion by a central action to inhibit irGnRH release into the hypophysial-portal circulation and that this action is independent of basal concentrations of irGnRH and/or LH.
CRF Positive_regulation (attenuates) of Localization (secretion) of LH
1) Confidence 0.45 Published 1987 Journal Endocrinology Section Abstract Doc Link 3542513 Disease Relevance 0 Pain Relevance 0.43
Experiments were carried out in castrate adult male rats to further examine whether endogenous opioids are involved in CRF-induced suppression of LH secretion.
CRF Positive_regulation (induced) of Localization (secretion) of LH associated with endogenous opioid
2) Confidence 0.36 Published 1988 Journal Endocrinology Section Abstract Doc Link 3257730 Disease Relevance 0 Pain Relevance 0.36

General Comments

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