INT36007

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.22
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
brain 4
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 57 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
cocaine 2 99.68 Very High Very High Very High
withdrawal 8 99.36 Very High Very High Very High
Ventral tegmentum 4 98.00 Very High Very High Very High
dopamine receptor 6 97.60 Very High Very High Very High
Morphine 3 97.36 Very High Very High Very High
Nucleus accumbens 10 97.04 Very High Very High Very High
Dynorphin 4 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 21 99.20 Very High Very High Very High
Cancer 4 97.92 Very High Very High Very High
Headache 3 92.64 High High
Parkinson's Disease 3 91.08 High High
Dementia 9 90.40 High High
Syndrome 6 90.04 High High
Cluster Headache 3 89.92 High High
Galactorrhea 1 89.28 High High
Prolactinoma 2 87.68 High High
Metastasis 4 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study using PET and F18-Methylspiroperidol found decreased dopamine D2 receptor binding during cocaine withdrawal and also a separate study using PET and F-18-Dopa discovered low dopaminergic brain activity.
Negative_regulation (decreased) of dopamine D2 receptor Binding (binding) of in brain associated with dopamine, withdrawal and cocaine
1) Confidence 0.57 Published 1994 Journal Addiction Section Abstract Doc Link 7841859 Disease Relevance 0.17 Pain Relevance 0.61
There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls.
Negative_regulation (reduction) of dopamine D2 receptor Binding (binding) of associated with dopamine
2) Confidence 0.42 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954746 Disease Relevance 0.35 Pain Relevance 0.40
In patients with Huntington's disease, mainly postsynaptic dysfunctions with reductions of striatal D1 (six out of six reports) and D2 receptor binding (15 out of 15 reports) were observed.
Negative_regulation (reductions) of D2 receptor Binding (binding) of associated with disease
3) Confidence 0.33 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19523490 Disease Relevance 1.19 Pain Relevance 0.14
As expected, dopaminergic systems are clearly downstream of Comt, including Maoa in the striatum, DRD1 and DRD2 binding density in multiple brain regions, and the response to the dopamine receptor antagonist haloperidol.
Negative_regulation (downstream) of DRD2 Binding (binding) of in brain associated with antagonist and dopamine receptor
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.07 Pain Relevance 0.45
Linkage of DRD1 and DRD2 binding was sex-specific and only detected in males.
Negative_regulation (detected) of DRD2 Binding (binding) of
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.12 Pain Relevance 0.37
Alpha-santalol was shown to be the most potent of the six as an antagonist of dopamine D2 and serotonine 5-HT2A receptor binding.
Negative_regulation (antagonist) of dopamine D2 Binding (binding) of associated with dopamine and antagonist
6) Confidence 0.20 Published 2000 Journal Phytomedicine Section Abstract Doc Link 11081993 Disease Relevance 0 Pain Relevance 0.55
Upregulated dopamine D2-like binding and enkephalin in D1(-/-) mice may be due to decreased dopamine turnover.
Negative_regulation (decreased) of D2 Binding (binding) of associated with dopamine and enkephalin
7) Confidence 0.11 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.28 Pain Relevance 1.42
The patient was subsequently treated with bromocriptine injections that resulted in a decrease in serum prolactin levels, decreased dopamine D2-receptor binding, reduced amino acid metabolism, and a reduction in tumor volume.
Negative_regulation (decreased) of D2-receptor Binding (binding) of associated with dopamine and cancer
8) Confidence 0.06 Published 1988 Journal Neurosurgery Section Abstract Doc Link 3258413 Disease Relevance 1.05 Pain Relevance 0.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox