INT36018

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.66
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cell 8
lymphocytes 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.88 Very High Very High Very High
agonist 13 99.16 Very High Very High Very High
methotrexate 6 99.08 Very High Very High Very High
chemokine 100 96.76 Very High Very High Very High
Pain 5 93.08 High High
cytokine 69 88.88 High High
withdrawal 2 86.80 High High
Opioid 1 84.64 Quite High
rheumatoid arthritis 2 82.56 Quite High
opiate 1 63.56 Quite High
Disease Link Frequency Relevance Heat
Diffuse Cutaneous Leishmaniasis 149 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 74 100.00 Very High Very High Very High
Hepatocellular Cancer 1 98.70 Very High Very High Very High
Cancer 166 98.52 Very High Very High Very High
Sprains And Strains 36 94.64 High High
Pain 4 93.08 High High
Death 21 92.92 High High
Cytomegalovirus Infection 6 92.88 High High
Pressure And Volume Under Development 10 92.72 High High
Infection 138 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine also inhibited CD8+ T cell-induced expression of the signal transducer and activator of transcription-1, an important transcriptional factor in the IFN signaling pathway.
Negative_regulation (inhibited) of Gene_expression (expression) of CD8 in T cell associated with morphine
1) Confidence 0.42 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16000393 Disease Relevance 0.88 Pain Relevance 0.79
High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes.
Negative_regulation (reduction) of Gene_expression (expression) of Leu 2 in lymphocytes associated with methotrexate
2) Confidence 0.41 Published 1988 Journal J. Rheumatol. Section Abstract Doc Link 3258915 Disease Relevance 0.34 Pain Relevance 0.30
We longitudinally examined a group of rhesus macaques infected with SIV and CD8+ cell depleted (n?
Negative_regulation (depleted) of Gene_expression (cell) of CD8
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.58 Pain Relevance 0.03
Prediction and selection of HLA class I restricted CD8+ T cell epitopes
Negative_regulation (Prediction) of Gene_expression (epitopes) of CD8 in T cell
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.17 Pain Relevance 0.04
To date, the mechanism responsible for the reduced presence of CD8 in lesions of DCL patients remains unclear.
Negative_regulation (reduced) of Gene_expression (presence) of CD8 associated with diffuse cutaneous leishmaniasis
5) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.16 Pain Relevance 0
We found that PD-1 expression in CD8+ of DCL patients was significantly reduced after stimulation with both TLR2 agonists, LPG (p?
Negative_regulation (reduced) of Gene_expression (expression) of CD8 associated with agonist and diffuse cutaneous leishmaniasis
6) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.58 Pain Relevance 0.14
TCR diversity spectratype analysis was performed on sorted CD4+ and CD8+ populations before and after (day 21) rhIL-7 therapy in 6 subjects treated at either 30 or 60 ?
Negative_regulation (sorted) of Gene_expression (populations) of CD8
7) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
Cohort 5 animal groups underwent thymectomy or CD8 depletion or both; the profound CD8 depletion in these animals is depicted in Figure 6.
Negative_regulation (depicted) of Gene_expression (depletion) of CD8
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996299 Disease Relevance 0.68 Pain Relevance 0.04
+ mono-functional CD8+ T cells corresponded to a loss of detectable mono-functional CD8+ T cells expressing TNF-?
Negative_regulation (loss) of Gene_expression (expressing) of CD8 in T cells
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.07 Pain Relevance 0.08
On the other hand, the aberrant expression of chemokines in tumors induces immunosuppression and favors tumor growth as shown in hepatocellular carcinoma, where high levels of CXCL9 and CXL10 have been associated with inhibition of CXCR3 expression by CD8+ T limphocytes, reduction of T-cell tumor infiltration and cytotoxic functions and tumor growth [48].
Negative_regulation (inhibition) of Gene_expression (expression) of CD8 in T-cell associated with chemokine, cancer and hepatocellular cancer
10) Confidence 0.09 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.49 Pain Relevance 0.43
MAIN RESULTS: Absolute number of CD3+, CD4+, and CD8+, and expression of HLA-DR and activation marker CD25+, CD26+, and CD69+ decreased more in response to surgery after BAL.
Negative_regulation (decreased) of Gene_expression (expression) of CD8
11) Confidence 0.04 Published 2005 Journal J Clin Anesth Section Body Doc Link 16297751 Disease Relevance 0.06 Pain Relevance 0
CD8 activation (as determined by co-expression of CD38 and HLA-DR) decreases during ART (4,16,22), probably reflecting to a large extent the reduction in HIV-specific CD8 response that accompanies the reduction in antigen load (42).
Negative_regulation (decreases) of Gene_expression (response) of CD8 associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.03 Published 2006 Journal Parasite Immunology Section Body Doc Link PMC1636681 Disease Relevance 0.64 Pain Relevance 0

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