INT3602

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Context Info
Confidence 0.53
First Reported 1976
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 148
Total Number 150
Disease Relevance 69.05
Pain Relevance 11.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
blood 10
heart 5
inferior 2
arm 2
14.2 2
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 14 99.90 Very High Very High Very High
anesthesia 73 99.84 Very High Very High Very High
Clonidine 22 99.84 Very High Very High Very High
Central nervous system 57 99.78 Very High Very High Very High
cva 176 99.46 Very High Very High Very High
narcan 22 99.20 Very High Very High Very High
antagonist 259 99.06 Very High Very High Very High
Migraine 40 98.92 Very High Very High Very High
headache 285 98.80 Very High Very High Very High
Pain 108 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 2998 100.00 Very High Very High Very High
Peritonitis 480 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 293 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 95 100.00 Very High Very High Very High
Reprotox - General 1 29 100.00 Very High Very High Very High
Obesity 92 99.90 Very High Very High Very High
Back Pain 2 99.90 Very High Very High Very High
Acute Coronary Syndrome 14 99.86 Very High Very High Very High
Dyspnea 18 99.70 Very High Very High Very High
Bradycardia 20 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decline in sex hormone levels that accompanies the menopause has substantial effects on the tissues of the urogenital system, leading to atrophic changes.
Negative_regulation (decline) of sex hormone in urogenital system associated with endometriosis (extended)
1) Confidence 0.53 Published 2009 Journal Maturitas Section Abstract Doc Link 19410391 Disease Relevance 0.45 Pain Relevance 0.08
The unaltered intratesticular T production contrasted with significantly lowered serum T concentration may reflect a reduction in sex hormone binding globulin (SHBG) essential for T transportation in blood [46].
Negative_regulation (reduction) of SHBG in blood
2) Confidence 0.52 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.60 Pain Relevance 0
With obesity, there is an increased risk for breast and endometrial cancer due, for most authors, to elevated levels of circulating estrogens resulting from aromatization of male sex steroids in adipose tissue and decreased levels of sex hormone-binding globulin.
Negative_regulation (decreased) of hormone-binding globulin in adipose tissue associated with endometriosis (extended) and obesity
3) Confidence 0.50 Published 1998 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 9578282 Disease Relevance 1.14 Pain Relevance 0.10
In the presence of moderate-dose narcotic, however, a decrease in SBP occurred in all three groups following induction of anaesthesia (P less than 0.003), with the largest decrease (17 +/- 4%) occurring in patients who had received E200.
Negative_regulation (decrease) of SBP
4) Confidence 0.50 Published 1991 Journal Can J Anaesth Section Abstract Doc Link 1683818 Disease Relevance 0.29 Pain Relevance 0.07
Nifedipine reduced SBP and DBP by respectively 6.5% and 13.1% at 8 am and 5.3% and 9.4% at 8 pm.
Negative_regulation (reduced) of SBP
5) Confidence 0.49 Published 1994 Journal Minerva Cardioangiol Section Abstract Doc Link 7753427 Disease Relevance 0.45 Pain Relevance 0.22
g/kg) to increase and reduce SBP by 15 - 30 mmHg, respectively.
Negative_regulation (reduce) of SBP
6) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.12 Pain Relevance 0.10
Fernández and colleagues (2007) have recently demonstrated the efficacy of norfloxacin in preventing SBP as its importance in the delay of hepatorenal syndrome.
Negative_regulation (preventing) of SBP associated with peritonitis and hepatorenal syndrome
7) Confidence 0.47 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 0.83 Pain Relevance 0.04
The nausea group demonstrated a significantly greater cumulative decrease in SBP than did the non-nausea group.
Negative_regulation (decrease) of SBP associated with vomiting
8) Confidence 0.46 Published 1991 Journal Nurse Anesth Section Abstract Doc Link 1888787 Disease Relevance 1.07 Pain Relevance 0.06
A beneficial change was seen in SHBG values in the paroxetine group in contrary to a decrease of SHBG in the placebo-treated group.
Negative_regulation (decrease) of SHBG
9) Confidence 0.43 Published 2003 Journal BMC Fam Pract Section Body Doc Link PMC165418 Disease Relevance 0.57 Pain Relevance 0.04
Administration of both drugs produced a significant suppression of elevation of SBP, and produced a significant elevation of pain sensitivity.
Negative_regulation (suppression) of SBP associated with pain
10) Confidence 0.41 Published 1991 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 1808360 Disease Relevance 1.02 Pain Relevance 0.75
Levels of sex hormone binding globulin (SHBG), a protein increased by EE to which NET binds, were also examined.
Spec (examined) Negative_regulation (Levels) of sex hormone binding globulin
11) Confidence 0.41 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0.09 Pain Relevance 0.18
Levels of sex hormone binding globulin (SHBG), a protein increased by EE to which NET binds, were also examined.
Spec (examined) Negative_regulation (Levels) of SHBG
12) Confidence 0.41 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0.09 Pain Relevance 0.18
Unlike estrogen, tibolone reduces SHBG, and hence may increase free circulating testosterone.
Negative_regulation (reduces) of SHBG
13) Confidence 0.40 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544356 Disease Relevance 0.60 Pain Relevance 0
The clinical diagnosis of SBP is neither sensitive nor specific and the search for new practical and available tools for a rapid diagnosis of SBP is an important endpoint of current studies.
Negative_regulation (diagnosis) of SBP associated with peritonitis
14) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2621420 Disease Relevance 1.30 Pain Relevance 0
The unaltered intratesticular T production contrasted with significantly lowered serum T concentration may reflect a reduction in sex hormone binding globulin (SHBG) essential for T transportation in blood [46].
Negative_regulation (reduction) of sex hormone in blood
15) Confidence 0.38 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.60 Pain Relevance 0
In contrast to the finding after training, nitroglycerin administered to subjects increased HR by 10%, but reduced SBP by 13%, RPP remaining unchanged.
Negative_regulation (reduced) of SBP
16) Confidence 0.38 Published 1976 Journal Circulation Section Abstract Doc Link 813911 Disease Relevance 0.20 Pain Relevance 0.20
In the presence of atenolol 2 mg kg(-1) h(-1), clonidine 10-100 microg kg(-1) i.v. evoked a significant reduction in SBP, a large increase of CVM firing rate from a very low base line [0.16 (sd 0.28) to 1.37 (1.21) spikes s(-1), n=7 cells], and increased the slope of the cardiac baroreflex analysed at the CVM level or at the heart level. sds of SBP were reduced, and that of RR interval was increased.
Negative_regulation (reduction) of SBP in spikes
17) Confidence 0.38 Published 2009 Journal Br J Anaesth Section Body Doc Link 19189981 Disease Relevance 0.07 Pain Relevance 0
These effects may be dependent on both estrogenic and androgenic actions exerted at the genital level and in the CNS, and to a reduction of SHBG and an increase of free T, without affecting ?
Negative_regulation (reduction) of SHBG associated with central nervous system
18) Confidence 0.37 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671819 Disease Relevance 0.70 Pain Relevance 0.09
IP infusion of naloxone at 300 micrograms/hr produced the same reductions of SBP as that at 150 micrograms/hr in DOCA-salt treated rats.
Negative_regulation (reductions) of SBP associated with narcan
19) Confidence 0.37 Published 1991 Journal Clin Exp Hypertens A Section Abstract Doc Link 2022070 Disease Relevance 0.53 Pain Relevance 0.38
Naproxcinod at all doses decreased mean SBP compared to an increase with rofecoxib.


Negative_regulation (decreased) of SBP
20) Confidence 0.37 Published 2009 Journal J. Rheumatol. Section Body Doc Link 19411388 Disease Relevance 0 Pain Relevance 0

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