INT36028

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Context Info
Confidence 0.40
First Reported 1988
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.82
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1r1) intracellular (Il1r1) protein complex (Il1r1)
signal transducer activity (Il1r1)
Anatomy Link Frequency
peritoneal cavity 2
Th17 cell 2
Il1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 99.74 Very High Very High Very High
Inflammation 39 95.68 Very High Very High Very High
cytokine 77 94.64 High High
Potency 2 91.48 High High
Morphine 1 79.20 Quite High
analgesia 1 75.00 Quite High
Pain 1 68.52 Quite High
Arthritis 86 59.96 Quite High
Hippocampus 13 48.52 Quite Low
Inflammatory response 9 32.48 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 7 99.12 Very High Very High Very High
Injury 58 98.16 Very High Very High Very High
INFLAMMATION 51 95.68 Very High Very High Very High
Penetrating Head Injuries 5 94.72 High High
Arthropathy 4 91.28 High High
Necrosis 7 83.88 Quite High
Cancer 7 83.52 Quite High
Stab Wounds 15 79.96 Quite High
Pain 1 68.52 Quite High
Experimental Arthritis 7 59.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, PAR-1 protein was not induced and remained undetectable in the IL-1R1-null mice.
Neg (not) Positive_regulation (induced) of Gene_expression (undetectable) of IL-1R1-null
1) Confidence 0.40 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.77 Pain Relevance 0.08
The activity of rHu-IL-1 alpha and rHu-TNF, unlike mIFN alpha, was not naloxone-reversible. rHu-IL-1 alpha did not produce an increase in writhes counts even if injected directly into the peritoneal cavity.
Positive_regulation (increase) of Neg (not) Gene_expression (produce) of rHu-IL-1 alpha in peritoneal cavity associated with narcan
2) Confidence 0.19 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3260869 Disease Relevance 0.37 Pain Relevance 0.40
IL-1 receptor 1 (IL-1R1) expression in T cells, which was induced by IL-6, was necessary for the induction of experimental autoimmune encephalomyelitis and for early Th17 cell differentiation in vivo [11].
Positive_regulation (necessary) of Gene_expression (expression) of IL-1R1 in Th17 cell associated with multiple sclerosis
3) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.42 Pain Relevance 0.11
LPS-induced microglial activation is modified by IL-1Ra and absent in IL-1R-/-
Positive_regulation (activation) of Neg (absent) Gene_expression (absent) of IL-1R
4) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.26 Pain Relevance 0.22

General Comments

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