INT36032

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Context Info
Confidence 0.72
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 10.55
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col3a1) extracellular region (Col3a1) proteinaceous extracellular matrix (Col3a1)
Anatomy Link Frequency
stem cell 3
skin 2
extracellular matrix 2
lung 2
stroma 1
Col3a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 13 98.08 Very High Very High Very High
Osteoarthritis 2 97.84 Very High Very High Very High
Inflammation 293 97.08 Very High Very High Very High
rheumatoid arthritis 2 97.08 Very High Very High Very High
fibrosis 181 96.72 Very High Very High Very High
Inflammatory marker 2 92.52 High High
corticosteroid 72 92.32 High High
Chronic pancreatitis 2 90.32 High High
cytokine 68 89.60 High High
spinal inflammation 2 73.68 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 84 100.00 Very High Very High Very High
Fibrosis 220 99.62 Very High Very High Very High
Osteoarthritis 2 97.84 Very High Very High Very High
INFLAMMATION 270 97.72 Very High Very High Very High
Rheumatoid Arthritis 2 97.08 Very High Very High Very High
Stress 27 96.88 Very High Very High Very High
Disease 64 96.28 Very High Very High Very High
Asthma 183 94.56 High High
Targeted Disruption 21 94.04 High High
Pancreatitis 7 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, much higher levels of gene expression of Col1A2 and Col3A1, and protein content of collagen were observed in bleomycin-induced lung tissues when they were compared to that in skin tissues (5.2-fold, 6.7-fold and 3.6-fold increase vs. 3.8-fold, 2.8-fold and 2.2-fold increase, respectively), which suggested that tissue damage and fibrosis in lung might be more severe than that in skin.
Gene_expression (expression) of Col3A1 in skin associated with fibrosis
1) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.64 Pain Relevance 0.30
The expression of several collagen genes (e.g., Col1a1 and Col3a1) exhibited age-associated declines.
Gene_expression (expression) of Col3a1
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2931699 Disease Relevance 0.86 Pain Relevance 0.12
Measurement of the aminoterminal type III procollagen peptide in serum has been suggested as a marker of the biosynthesis of collagen type III, a major connective tissue component in repair processes.
Gene_expression (biosynthesis) of collagen type III in connective tissue
3) Confidence 0.66 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3261674 Disease Relevance 0.46 Pain Relevance 0.26
However, in Ctgf siRNA or SPARC siRNA treated mice skin that also received bleomycin injection, the expression of the Col1a2 and Col3a1 appeared to be normal in skin tissues (Figure 5A, P = 0.025 and 0.003 for each gene in Ctgf siRNA treatment, and P = 0.031 and 0.010 in SPARC siRNA treatment), and were significantly improved in lung tissues (about 2.7-fold reduction for Col1a2 and 1.9-fold reduction for Col3a1, compared to bleomyin-injected mice without siRNA treatment, P < 0.05 for both) (Figure 5B).
Gene_expression (expression) of Col3a1 in lung
4) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.08 Pain Relevance 0
Transcripts representing COL3A1 and SPARC were present at two different locations on the array, and in each case, both sets of duplicate spots showed consistent upregulation in the absence of IL-11R?.
Gene_expression (representing) of COL3A1
5) Confidence 0.54 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
We confirmed significantly lower transcript levels of Col1a1, Col1a2, Col3a1 and Col4a1 in aged stroma by qRT-PCR (Figure 5A).
Gene_expression (levels) of Col3a1 in stroma
6) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.43 Pain Relevance 0.08
This implies that the propeptide level reflects the collagen type III synthesis occurring in the synovial repair processes, whether they were caused by inflammatory or degenerative rheumatic disorders.
Gene_expression (synthesis) of collagen type III associated with inflammation
7) Confidence 0.51 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3261674 Disease Relevance 0.61 Pain Relevance 0.34
To confirm differential expression of collagen III, biglycan, SPARC and nidogen-1 at the protein level, immunohistochemistry was carried out on transverse sections of IL11Ra+/+ and IL11Ra-/- uterus collected at 48 h of decidualization, using specific antibodies (n = 5 mice per genotype, n = 3 sections per mouse).
Gene_expression (expression) of collagen III in uterus
8) Confidence 0.48 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Following normalization, levels of RNA for COL3A1, BGN, SPARC and NID1 in IL11Ra-/- compared to wild type were statistically analysed using the paired t-test function of GraphPad Prism 3.0 (GraphPad Software, San Diego, CA).
Gene_expression (levels) of COL3A1
9) Confidence 0.48 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Each of the ECM molecules investigated further in this study, collagen III, biglycan, nidogen-1 and SPARC, showed protein expression patterns consistent with a role in decidualization, with immunostaining in endometrial stromal cells and their surrounding matrices.
Gene_expression (expression) of collagen III in stromal cells
10) Confidence 0.48 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.07 Pain Relevance 0
To confirm the altered mRNA expression of the ECM genes COL3A1, SPARC, BGN and NID1 at 48 h of decidualization, quantitative real-time RT-PCR was carried out using the same RNA samples used in the microarray analysis, plus two additional RNA samples of each genotype, collected in the same way.
Gene_expression (expression) of COL3A1
11) Confidence 0.48 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
On day 14 after birth, fibrotic tissue was mainly composed of collagen type I and III.
Gene_expression (composed) of collagen type I and III associated with fibrosis
12) Confidence 0.41 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.86 Pain Relevance 0.20
Proinflammatory mediators, reactive oxygen species, and TGF-beta can activate pancreatic stellate cells and their synthesis of collagen I and III.
Gene_expression (synthesis) of collagen I and III in stellate cells
13) Confidence 0.23 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 0.85 Pain Relevance 0.29
COL1A1 and COL3A1 are significantly down expressed as compared to the control when exposed to the osteoplant, probably because these genes are activated in the late stage of differentiation and are related to extracellular matrix synthesis.
Gene_expression (expressed) of COL3A1 in extracellular matrix
14) Confidence 0.22 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.32 Pain Relevance 0
At 3 days the top networks identified by IPA involve cell cycle progression (up-regulation of Foxm1, Cdc2, Cdc20, Ccnd1 and IL6 - Figure 4A), and activation of fibroblastic cells with production of extracellular matrix components (up-regulation of Igf1, Tnfrsf12A, Eln, Fbn1, Col3A1, Serpine1 and Thbs1 - Figure 4B).
Gene_expression (production) of Col3A1 in extracellular matrix
15) Confidence 0.21 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.48 Pain Relevance 0.24
Transcriptional expressions of several osteoblast-related genes (RUNX2, SP7, SPP1, COLIA1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cell markers (ENG) were examined after seven days of treatment with osteoplant.
Spec (examined) Gene_expression (expressions) of COL3A1 in stem cell associated with osteoporosis
16) Confidence 0.20 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.10 Pain Relevance 0
In order to get a better insight into how the osteoplant acts on PB-hMSCs, changes in expression of bone-related marker genes (RUNX2, SP7, SPP1, COLIA1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells markers (ENG) were investigated by real-time RT-PCR.
Gene_expression (expression) of COL3A1 in stem cells
17) Confidence 0.20 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.07 Pain Relevance 0
To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, such as, transcriptional factors (RUNX2 and SP7), bone-related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1), and mesenchymal stem cell markers (ENG) were examined, by means of real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR).


Gene_expression (expression) of COL3A1 in stem cell
18) Confidence 0.20 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.09 Pain Relevance 0
1 and collagen type III expression the sections were incubated with a mouse anti-TGF-?
Gene_expression (expression) of collagen type III
19) Confidence 0.15 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2805797 Disease Relevance 0.87 Pain Relevance 0.42
Immunohistochemistry was used to measure collagen III deposition and TGF-?
Gene_expression (deposition) of collagen III
20) Confidence 0.15 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Abstract Doc Link PMC2805797 Disease Relevance 1.01 Pain Relevance 0.25

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