INT36039

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Context Info
Confidence 0.72
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 3.75
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) transport (Itpr3) endoplasmic reticulum (Itpr3)
nucleolus (Itpr3) nucleus (Itpr3) transmembrane transport (Itpr3)
Anatomy Link Frequency
papillae 3
reticulum 2
Hyp3 1
platelets 1
taste buds 1
Itpr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 7 100.00 Very High Very High Very High
agonist 131 98.76 Very High Very High Very High
bradykinin 22 98.72 Very High Very High Very High
Enkephalin 2 98.64 Very High Very High Very High
Antinociceptive 1 97.96 Very High Very High Very High
Pain threshold 3 97.44 Very High Very High Very High
Opioid 2 96.80 Very High Very High Very High
antagonist 21 95.44 Very High Very High Very High
member 8 20 94.12 High High
Analgesic 2 87.56 High High
Disease Link Frequency Relevance Heat
Pain 5 97.44 Very High Very High Very High
Apoptosis 138 94.64 High High
Brain Hemorrhage 32 87.76 High High
Cv General 4 Under Development 12 86.72 High High
Death 71 84.00 Quite High
Bordatella Infection 2 81.36 Quite High
Muscular Atrophy 1 80.48 Quite High
Contracture 1 79.68 Quite High
Syndrome 2 77.52 Quite High
Disease 152 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, the results showed that almost all Lrmp/Jaw1-expressing taste cells also expressed IP3R3 in CV papillae (Figure 3).


Gene_expression (expressed) of IP3R3 in papillae
1) Confidence 0.72 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
Lrmp/Jaw1 was coexpressed with IP3R3
Gene_expression (coexpressed) of IP3R3
2) Confidence 0.72 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.06 Pain Relevance 0
To investigate the coexpression patterns of Lrmp/Jaw1 and IP3R3 at the translational level, we performed double-colored immunohistochemistry using CV papillae sections.
Spec (investigate) Gene_expression (coexpression) of IP3R3 in papillae
3) Confidence 0.72 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
However, this is difficult to justify, at least for IP3R3 trafficking, because deletion of the potential binding domain (coiled-coil domain of Lrmp/Jaw1) did not alter IP3R3 expression on the ER membrane in the COS7 heterologous expression system.
Gene_expression (expression) of IP3R3
4) Confidence 0.72 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0.14 Pain Relevance 0
Because IP3R3 was coexpressed with Trpm5 in taste buds (PĂ©rez et al. 2002), we predicted that Lrmp/Jaw1 may colocalize and interact with IP3R3.
Gene_expression (coexpressed) of IP3R3 in taste buds
5) Confidence 0.72 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
IP3(1,3,4) formed from inositol 1,3,4,5-tetrakisphosphate, which is itself a product of IP3(1,4,5), causes a slower depolarization by a mechanism that does not involve Na+ channels or an increase in [Ca++]i.
Gene_expression (product) of IP3
6) Confidence 0.67 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3262737 Disease Relevance 0.07 Pain Relevance 0.06
Dibutyryl cyclic GMP produced little or no inhibition of IP3.
Gene_expression (produced) of IP3
7) Confidence 0.67 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3494104 Disease Relevance 0.23 Pain Relevance 0.62
2 to produce IP3, which induces calcium (Ca2+) release through IP3R3 located on the membrane of endoplasmic reticulum (ER).
Gene_expression (produce) of IP3 in reticulum
8) Confidence 0.63 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0.19
To investigate the coexpression patterns of Lrmp/Jaw1 and IP3R3 at the translational level, we performed double-colored immunohistochemistry using CV papillae sections.
Spec (investigate) Gene_expression (patterns) of IP3R3 in papillae
9) Confidence 0.56 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
In our study, we found that Lrmp/Jaw1, a gene encoding lymphoid-restricted membrane protein (Behrens et al. 1994; Hoon and Ryba 1997), was coexpressed with molecules in the IP3-Ca2+ signal cascade in taste cells.
Gene_expression (coexpressed) of IP3
10) Confidence 0.55 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
Pretreatment with D-myo inositol, compound which produces InsP3, and 4-chloro-m-cresol, a RyR agonist, induced an antinociceptive effect.
Gene_expression (produces) of InsP3 associated with agonist and antinociceptive
11) Confidence 0.50 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15527827 Disease Relevance 0.54 Pain Relevance 0.80
Coexpression of Lrmp/Jaw1 with the molecules related with IP3-Ca2+ signal cascade such as G?
Gene_expression (Coexpression) of IP3
12) Confidence 0.49 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
The expression plasmid of rat IP3R3 (Blondel et al. 1993) was kindly provided by Dr Graeme I.
Gene_expression (expression) of IP3R3
13) Confidence 0.49 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
In particular, [D-Arg0]-Hyp3-Thi5,8-[D-Phe7]-bradykinin [Hyp, hydroxyproline; Thi, beta-(2-thienyl)-L-alanine] blocked IP3 production in a dose-dependent fashion.
Gene_expression (production) of IP3 in Hyp3 associated with bradykinin
14) Confidence 0.45 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3494104 Disease Relevance 0.37 Pain Relevance 0.58
Although these agonists trigger different signaling pathways, all activate phospholipase Cs (PLCs), leading to the production of diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3).
Gene_expression (production) of IP3 associated with agonist
15) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.71 Pain Relevance 0.08
2 stimulation (Fig. 2 A), suggesting different kinetics of IP3 production between these two pathways that could influence subsequent events.
Gene_expression (production) of IP3
16) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0 Pain Relevance 0.16
M1 receptors are thought to couple to Gq/11 subunits whose downstream signaling bifurcates into the production of IP3 and DAG, leading to activation of PKC (Delmas and Brown, 2005).
Gene_expression (production) of IP3
17) Confidence 0.05 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.03
, are viable with no obvious neurological defects, although they have some defects in fertility, decreased platelet levels (30%) of PI(4,5)P2 and impaired thrombin-induced IP3 production in platelets (45).
Gene_expression (production) of IP3 in platelets
18) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937898 Disease Relevance 0.37 Pain Relevance 0
Gq/11 subunits' downstream signaling bifurcates into the production of IP3 and DAG, which has been shown to promote Ca2+ release from intracellular stores, activate PKC, and locally deplete PIP2 levels (Delmas and Brown, 2005).
Gene_expression (production) of IP3
19) Confidence 0.04 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.07 Pain Relevance 0.17
proteins with subsequent phospholipase C activation, generation of inositol 1,4,5-triphosphate (IP3), and intracellular Ca2+ release.
Gene_expression (generation) of IP3
20) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2494688 Disease Relevance 0.14 Pain Relevance 0.15

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