INT3605

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Context Info
Confidence 0.38
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 10.88
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1) mitochondrion organization (OPA1) GTPase activity (OPA1)
Anatomy Link Frequency
brachial artery 1
brain 1
platelets 1
sublingual 1
heart 1
OPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
tolerance 5 99.20 Very High Very High Very High
qutenza 3 96.40 Very High Very High Very High
nMDA receptor 2 94.92 High High
Angina 7 92.96 High High
ischemia 45 88.44 High High
transdermal 2 87.44 High High
monoamine 1 85.84 High High
Calcitonin gene-related peptide 4 83.08 Quite High
headache 1 82.48 Quite High
Disease Link Frequency Relevance Heat
Glaucoma 302 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 248 100.00 Very High Very High Very High
Low Tension Glaucoma 62 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
Myocardial Infarction 15 99.44 Very High Very High Very High
Coronary Heart Disease 6 99.40 Very High Very High Very High
Chronic Renal Failure 20 99.08 Very High Very High Very High
Ocular Hypertension 100 98.78 Very High Very High Very High
Heart Rate Under Development 11 98.20 Very High Very High Very High
Arrhythmias 2 Under Development 7 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the effectiveness of NTG during acute myocardial iinfarction (AMI) in man has been studied.
Negative_regulation (effectiveness) of NTG
1) Confidence 0.38 Published 1976 Journal Circulation Section Abstract Doc Link 815059 Disease Relevance 1.25 Pain Relevance 0.13
Nitroglycerin (NTG) traditionally has bben avoided in the treatment of pain caused by acute myocardial infarction because of the belief that NTG-induced decrease in arterial pressure and concomitant reflex increase in heart rate might extend the ischemic process.
Negative_regulation (decrease) of NTG-induced in heart associated with pain, heart rate under development and myocardial infarction
2) Confidence 0.38 Published 1976 Journal Circulation Section Abstract Doc Link 815059 Disease Relevance 0.55 Pain Relevance 0.16
During the study only sublingual NTG was allowed, and its consumption and the number of attacks recorded.
Negative_regulation (allowed) of NTG in sublingual
3) Confidence 0.37 Published 1988 Journal Am. J. Cardiol. Section Abstract Doc Link 3126635 Disease Relevance 0.24 Pain Relevance 0.32
These differences are attributed to different effects of NTG and PETN on the expression of antioxidative proteins like the heme oxygenase-I.
Negative_regulation (effects) of NTG
4) Confidence 0.34 Published 2009 Journal Physiol. Genomics Section Abstract Doc Link 19417013 Disease Relevance 0.28 Pain Relevance 0.09
We found a significant decrease in nBR pain and reflex thresholds both 1 and 4 h post-NTG.
Negative_regulation (decrease) of NTG associated with pain
5) Confidence 0.30 Published 2009 Journal Pain Section Abstract Doc Link 19457613 Disease Relevance 0.50 Pain Relevance 0.41
In a study of 28 patients with chronic renal failure (13 on hemodialysis), both flow-mediated and NTG-induced brachial artery vasodilation were impaired to comparable degrees [28].
Negative_regulation (impaired) of NTG in brachial artery associated with chronic renal failure and increased venous pressure under development
6) Confidence 0.30 Published 2008 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2467421 Disease Relevance 1.91 Pain Relevance 0.03
Furthermore, the female gender is considered an independent risk factor for visual field loss progression in NTG (Orgul et al 1994; Drance et al 2001).
Negative_regulation (loss) of NTG associated with low tension glaucoma
7) Confidence 0.24 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 2.11 Pain Relevance 0.14
The differences between NTG and controls were reversed during elevated CO2 breathing, suggesting the presence of a reversible vasospasm in the NTG cohort (Harris et al 1994).
Negative_regulation (reversed) of NTG associated with low tension glaucoma and increased venous pressure under development
8) Confidence 0.24 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.78 Pain Relevance 0.13
Infarct size also reduced from 58+/-4.7% in the control group to 31+/-3.7% in the NTG group.
Negative_regulation (reduced) of NTG
9) Confidence 0.09 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18584896 Disease Relevance 0.27 Pain Relevance 0.60
These data indicate that the biochemical and antiaggregation effects of NTG on platelets are not diminished during hemodynamic tolerance and that these effects may be dependent on extraplatelet production of nitric oxide (NO).
Neg (not) Negative_regulation (diminished) of NTG in platelets associated with tolerance
10) Confidence 0.07 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877591 Disease Relevance 0.17 Pain Relevance 0.18
A previous study reported average rates of decline in NTG as ?
Negative_regulation (decline) of NTG associated with glaucoma
11) Confidence 0.05 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.53 Pain Relevance 0.34
A long-term collaborative study conducted in North America and Europe revealed that a 30% reduction in IOP exerted positive effects on the progression of visual field loss in NTG (Collaborative Normal-Tension Glaucoma Study Group 1998a).
Negative_regulation (loss) of NTG associated with glaucoma and ocular hypertension
12) Confidence 0.05 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 1.29 Pain Relevance 0
Although the association between AGAP3 and glaucoma is unclear, AGAP3 polymorphisms may act as risk factors in the development of NTG.
Negative_regulation (development) of NTG associated with low tension glaucoma and glaucoma
13) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2842094 Disease Relevance 0.80 Pain Relevance 0
Our data suggest that the stimulating effect of NTG, and thus of NO, on the expression of nNOS might be modulated by increasing the KYNA level in the brain, probably through the NMDA receptors.
Negative_regulation (effect) of NTG in brain associated with nmda receptor
14) Confidence 0.03 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.20 Pain Relevance 0.32

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